DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and L3MBTL3

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_006715639.1	Gene:	L3MBTL3 / 84456	HGNCID:	23035	Length:	815	Species:	Homo sapiens

Alignment Length:	921	Identity:	232/921 - (25%)
Similarity:	337/921 - (36%)	Gaps:	275/921 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SAAPGASTN--------ATSSASASASSTSTSASPGSTTSPASTQRQRGRPAKRATCTWCGEGKL 71
            |:.|...||        :||.|..|..|:.....|...|||.      |.|.     .:..:..:
Human    86 SSTPMVVTNTYMLMTPKSTSPAPTSPPSSRPVFPPAYWTSPP------GCPT-----VFSEKTGM 139

  Fly    72 PLQYVLPTQTGKKEFCSETC-IAEFRKAYSKG-ACTQ-CDNVIRDGAPNKEFCSIMCMNKHQKKN 133
            |.:...|.:....:||...| .....:..|.| .|:| |...|:| ...||...:...|:.:...
Human   140 PFRLKDPVKVEGLQFCENCCQYGNVDECLSGGNYCSQNCARHIKD-KDQKEERDVEEDNEEEDPK 203

  Fly   134 CS------------TRHSG-----------------GSASGKGLAESERKLLASGAPAPTGPFQY 169
            ||            |:..|                 ||...:.....:..:|..|.| |.|.
Human   204 CSRKKKPKLSLKADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLP-PKGK--- 264

  Fly   170 ESFHVFDWDAYLEETGSEAAPAKCFKQAQNPP--NNDFKIGMKLEALDPRNVTSTCIATVVGVLG 232
               ..:.|.:||||..:.|.|||.||:.|:.|  .|.||:|||||.:||.:.:..|:.||..|.|
Human   265 ---KAWCWASYLEEEKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCG 326

  Fly   233 SRLRLRLDGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQPPLGFRMNASSWPGYL--CKILNNAM 295
            .|::|..||.....|||...|:.:||.:|.|||.|..|.||.|::....:|..||  ||    |.
Human   327 YRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCK----AQ 387

  Fly   296 VAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWRGAFDYWCN 360
            .||:.:|:.:......:.|:||.||||||||||..||.|||..:.|::..|.||.|..::||||.
Human   388 AAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCE 452

  Fly   361 YRSRDIFPAGWCARSCHPM-QPPGHKSRMDSSSSKQRCPRPRYTVVAESEAMVPASPATAHFHPN 424
            ..|..|.|.|||......: .|||:.:....|..|          ..|....:|| ||.| |...
Human   453 ASSPHIHPVGWCKEHRRTLITPPGYPNVKHFSWDK----------YLEETNSLPA-PARA-FKVK 505

  Fly   425 CKGGPFINNSKLPCM-VTGPTYQTLAKLCLQEVLAASTDTQQLSKLLF------------ALEGD 476
            ...| |....||..: ...|.:..:|.:       |.||..:: |:.|            |...|
Human   506 PPHG-FQKKMKLEVVDKRNPMFIRVATV-------ADTDDHRV-KVHFDGWNNCYDYWIDADSPD 561

  Fly   477 VHIVTAAGKNFTVKIP--SPMRMKDDESLAQFIETLCTTCRACANLISLVHETEECKKCAN-SRK 538
            :|.|....|......|  ||:.:.:           .:....|:        |..||...: .|.
Human   562 IHPVGWCSKTGHPLQPPLSPLELME-----------ASEHGGCS--------TPGCKGIGHFKRA 607

  Fly   539 RQL--TQSATPPSSPVLADKRNRQSNSATTSPSEKIIKQELAVKSPVESKSKTSTNNGKEPASQQ 601
            |.|  ..:|..|.|.:..:|             ::|....|:.:.|              |||..
Human   608 RHLGPHSAANCPYSEINLNK-------------DRIFPDRLSGEMP--------------PASPS 645

  Fly   602 NSNHSLNNNNNSASKSSNKVVIKSEPNGANAQTSSTTQALRKVRFQHHANTNTNSSATNGNQDTS 666
            ..    .|....|::||      |.|               ::|.||         |.:..:|..
Human   646 FP----RNKRTDANESS------SSP---------------EIRDQH---------ADDVKEDFE 676

  Fly   667 QTT--HVSTSHCSSSSTSSSTSLAGGSANTSTIGKYLAPLVAEVHPEQANVKPSNSYYKSPTTLS 729
            :.|  .:.|||           .|.|:....|:             :||.       .:|...||
Human   677 ERTESEMRTSH-----------EARGAREEPTV-------------QQAQ-------RRSAVFLS 710

  Fly   730 SSASLPTSVSTPFTGC-----QSASSTALAAGGVTAAKAATAPAGAAATAGASPSYTAITSPVST 789
            ..:.:|         |     :..|.......|:.|:|.:
Human   711 FKSPIP---------CLPLRWEQQSKLLPTVAGIPASKVS------------------------- 741

  Fly   790 PTSALANSHLRSQPIDWTIEEVIQYIESNDNSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLK 854
                           .|:.:||.::|:|.. ....||.:|:..:|||:|.||:....::|.|.:|
Human   742 ---------------KWSTDEVSEFIQSLP-GCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIK 790

  Fly   855 LGPALKICNLV 865
            |||||||.|.:
Human   791 LGPALKIFNSI 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998	7/40 (18%)
		MBT	178..273	CDD:214723	43/96 (45%)
		MBT	<312..382	CDD:214723	33/70 (47%)
		DUF3588	418..524	CDD:288954	22/120 (18%)
		SAM_Scm	800..870	CDD:188977	25/66 (38%)
		SAM	806..867	CDD:197735	25/60 (42%)
L3MBTL3	XP_006715639.1	MBT	271..367	CDD:214723	43/95 (45%)
		MBT	380..474	CDD:214723	41/97 (42%)
		MBT	486..578	CDD:214723	24/112 (21%)
		zf-C2HC	592..619	CDD:279824	8/34 (24%)
		SAM	740..806	CDD:197735	25/103 (24%)
		SAM_Scm-like-3MBT3,4	740..805	CDD:188981	25/103 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910