DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Scm and L3MBTL2

DIOPT Version :9

Sequence 1:NP_001247006.1 Gene:Scm / 41168 FlyBaseID:FBgn0003334 Length:877 Species:Drosophila melanogaster
Sequence 2:NP_113676.2 Gene:L3MBTL2 / 83746 HGNCID:18594 Length:705 Species:Homo sapiens


Alignment Length:713 Identity:148/713 - (20%)
Similarity:210/713 - (29%) Gaps:310/713 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GGRDS----STSSGSNSAAPGASTNATSSASASASSTSTSASPGSTTSPASTQRQRGRPAKRATC 63
            ||.||    ::|.||.|::....::...:....|....|  ||....||.:.:...|..::.|.|
Human    28 GGYDSFRSYNSSVGSESSSYLEESSEAENEDREAGELPT--SPLHLLSPGTPRSLDGSGSEPAVC 90

  Fly    64 TWCGEGKLPLQYVLPTQ----TGKKEFCSETCIAEFRKAYSKGACTQCDNVIRDGAPNKEFCSIM 124
            ..||        ::.|:    :..|.|||.:|    .::||.               |.:..||:
Human    91 EMCG--------IVGTREAFFSKTKRFCSVSC----SRSYSS---------------NSKKASIL 128

  Fly   125 C--MNKHQKKNCSTRHSGGSAS--GKGLAESERKLLASGAPAPTGPFQYESFHVFDWDAYLEETG 185
            .  ..|...|.....|....::  |..|.......||.|  .|||  |......|||..:|::..
Human   129 ARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADG--TPTG--QDALVLGFDWGKFLKDHS 189

  Fly   186 SEAAPAKCFKQA-------------------------------------------------QNPP 201
            .:|||..|||..                                                 :|..
Human   190 YKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDA 254

  Fly   202 NNDF-------------------KI---------------------------------------- 207
            ::||                   ||                                        
Human   255 SHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESM 319

  Fly   208 ------GMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHAIG----- 261
                  ||:||.:|...|:.|.:|.|..|:|.||||..:..||.:|||..:.|..||.:|     
Human   320 KYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRV 384

  Fly   262 ----------------------------------------------------------------- 261
                                                                             
Human   385 GHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVAT 449

  Fly   262 ---------------------------------------HCEKNGGMLQPPLGFRMNASSWPGYL 287
                                                   .|:||...|.||.|:.....:|..||
Human   450 VCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYL 514

  Fly   288 CKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWR 352
            .|..:.|  ||..:|..:.|   .:.||||.||||||...|:|||.|||..:....:.:.||||.
Human   515 EKTKSKA--APSRLFNMDCP---NHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWD 574

  Fly   353 GAFDYWCNYRSRDIFPAGWCARSCHPMQPPGHKSRMDSSSSKQRCPRPRYTVVAESEAMVPASPA 417
            ..:|.|.:..|.||:|.|||..:.:.:|||                     |.||....:.|..|
Human   575 SEYDQWVDCESPDIYPVGWCELTGYQLQPP---------------------VAAEPATPLKAKEA 618

  Fly   418 TAHFH----------PNCKGGPFINNSKLPCMVTGPTYQTLAKLCLQ----EVLAASTDTQQL 466
            |....          |..|..|....||.|.:...|  |...|:..:    |::|.....:.|
Human   619 TKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDP--QGARKISSEPVPGEIIAVRVKEEHL 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ScmNP_001247006.1 zf-FCS 55..95 CDD:283998 11/43 (26%)
MBT 178..273 CDD:214723 40/317 (13%)
MBT <312..382 CDD:214723 31/69 (45%)
DUF3588 418..524 CDD:288954 13/63 (21%)
SAM_Scm 800..870 CDD:188977
SAM 806..867 CDD:197735
L3MBTL2NP_113676.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..84 15/57 (26%)
MBT 1 179..283 15/103 (15%)
MBT 183..283 CDD:214723 12/99 (12%)
MBT 2 291..391 24/99 (24%)
MBT 294..390 CDD:214723 24/95 (25%)
MBT 3 397..500 4/102 (4%)
MBT 408..500 CDD:214723 4/91 (4%)
MBT 4 508..604 40/100 (40%)
MBT 511..604 CDD:214723 39/97 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 608..665 13/58 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..705 148/713 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3766
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.