DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and scml4

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_001332433.4	Gene:	scml4 / 794170	ZFINID:	ZDB-GENE-041210-338	Length:	475	Species:	Danio rerio

Alignment Length:	714	Identity:	152/714 - (21%)
Similarity:	237/714 - (33%)	Gaps:	298/714 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 MKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDSQ-NDFWRLVDSTE---------------- 256
            |:|...|..:.|.:.|.:|:||...|||||||..|.: ...|:|||..|
Zfish     1 MRLRGRDLEDSTVSWIPSVLGVQSVRLRLRLDRRDDRGRSLWQLVDLGEEVQSGRRPRDRTPPTC 65

  Fly   257 ------IHAIGHCEKNGGMLQPPLGFRMNASSWPGYLCKILNNAMVAPEEIFQPEPPEPEENLFK 315
                  |.|....:..||.:|.|                    .:::|..:    ||...    |
Zfish    66 SQSLMSIPAAPSVQSGGGEMQSP--------------------GVISPSFL----PPASG----K 102

  Fly   316 V-GQKLEAVD-KKNPQLICCATVDAIKDDQIHVTFDGWRGAFDYWCNYRSRDIFPAGWCARSCHP 378
            | |:|..... |::|:                               |:||  :|     .|..|
Zfish   103 VPGRKRGRPPLKRHPE-------------------------------YQSR--YP-----ESLPP 129

  Fly   379 MQPPGHKSRMDSSSSKQR------------CPRPRYTVVAESEAMVP--ASP----ATAHFHPNC 425
            ::.|..:.|......|.|            .|.|..:.:.:..|.:|  |:|    ...:.:...
Zfish   130 IKVPKKRGRKPGFKLKSRLMTPLAISPPSSTPEPDMSSIPQDAATIPHSATPQVLTVCIYVNKQV 194

  Fly   426 KGGPFINNSK---LPCMVTGPTYQTLAKLCLQEVLAASTDTQQLSKLLFAL-----EGDVHIVTA 482
            ..||.::..|   ||..: ||...::.   ||:.:....|:....|.:|.|     .|:....|.
Zfish   195 NTGPNLDRQKVLQLPDHL-GPARPSVV---LQQAVQGCIDSAFQQKAVFTLLTEGYGGEKISATF 255

  Fly   483 AGKNFTVKIPSPMRMKDDESLAQFIETLCTTCRACANLISLVHETEECKKCANSRKRQLTQSATP 547
            .||...:.:|.   :.....:.:|::.||.:. .|.||.|                   .|...|
Zfish   256 DGKQHLLSLPV---VNSVGYVLRFLKKLCRSL-LCENLFS-------------------DQPIAP 297

  Fly   548 PSSPVLADKRNRQSNSATTSPSEKIIKQELAVKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNN 612
            .|||                                               |..:|.| :..:::
Zfish   298 SSSP-----------------------------------------------SSSSSFH-MEKHSD 314

  Fly   613 SASKSSNKVVIKSEPNGANAQTSSTTQALRKVRFQHHANTNTNSSATNGNQDTSQTTHVSTSHCS 677
            ..|||::.|                        ..:|.::
Zfish   315 GQSKSNSMV------------------------DDYHGDS------------------------- 330

  Fly   678 SSSTSSSTSLAGGSANTSTIGKYLAPLVAEVHPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPF 742
                                          |.|::.:|.||:         ..:.|.|.:.|.|.
Zfish   331 ------------------------------VEPKRYSVDPSD---------FGAMSSPYAASKPA 356

  Fly   743 TGCQSASSTALAAGGV--TAAKAATAPAGAAATAGASPSYTAITSPVSTPTSALANSHLRSQPID 805
            .|.:|||:   .:||:  .||..:|.|.|..:....||....:..|.|            ..|..
Zfish   357 YGFRSASA---YSGGICRQAASPSTFPEGNRSAYSPSPDAGEVKPPPS------------KDPSR 406

  Fly   806 WTIEEVIQYIESND-NSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            |:::||:.:|:..| .:|..|.:|||||||||.|||||.|:|:|||:|||||||||:|..::|:
Zfish   407 WSVDEVVWFIKDADPQALGPHVELFRKHEIDGDALLLLKSDMIMKYLGLKLGPALKLCYHIDKL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	26/86 (30%)
		MBT	<312..382	CDD:214723	12/71 (17%)
		DUF3588	418..524	CDD:288954	25/113 (22%)
		SAM_Scm	800..870	CDD:188977	38/70 (54%)
		SAM	806..867	CDD:197735	36/61 (59%)
scml4	XP_001332433.4	DUF3588	185..293	CDD:288954	25/134 (19%)
		SAM_Scm	401..472	CDD:188977	39/82 (48%)
		SAM	404..472	CDD:197735	38/67 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7958
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123551at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.970