DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and scml2

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_012812742.2	Gene:	scml2 / 780057	XenbaseID:	XB-GENE-6043728	Length:	706	Species:	Xenopus tropicalis

Alignment Length:	816	Identity:	263/816 - (32%)
Similarity:	363/816 - (44%)	Gaps:	249/816 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 FDWDAYLEETGSEAAPAKCFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRL 239
            |:||.||.:.||.|||..||||::.||:||||:||||||.||||:||.|||||||:.|:||||||
Frog    14 FNWDDYLNQVGSVAAPPNCFKQSRTPPSNDFKVGMKLEAHDPRNITSICIATVVGITGARLRLRL 78

  Fly   240 DGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQPPLGFRMNASSWPGYLCKILNNAMVAPEEIFQP 304
            ||||.:|||||||||.:|..||.|||.|.||||||||||||||||.:|.|.||.|.:||...|:.
Frog    79 DGSDDKNDFWRLVDSCDIQQIGTCEKKGDMLQPPLGFRMNASSWPMFLLKTLNGADMAPITCFKQ 143

  Fly   305 EPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWRGAFDYWCNYRSRDIFPA 369
            ||.:|.::.||.|.||||||||||.|||.||:..:|.|.|.:|||||||||||||.|.||||||.
Frog   144 EPQKPSQSFFKTGMKLEAVDKKNPYLICPATIGDVKGDDIFITFDGWRGAFDYWCKYDSRDIFPI 208

  Fly   370 GWCARSCHPMQPPGHKSRMDSSSS------------------------------KQRC------- 397
            |||:.:...:||||:...:..:||                              :.:|
Frog   209 GWCSLTGDSLQPPGNSVSLPRTSSTPTASPIKGVRRSMQSPQKPVQAQKGRKPMRDKCLGQTSAS 273

  Fly   398 ----PRPRYTVV------AESEAMVPASPATAHFHPNCKGGPFINNSKLPCM------------- 439
                .||:.|.:      ||::.   .|..|. ..|..|......||.||.:
Frog   274 PRKGKRPKNTTLSRNTPNAENQT---KSKGTG-LKPGRKKETLALNSSLPPVNTSDGDSNKSQIL 334

  Fly   440 -----VTGPTYQTLAKLC---------------------------------LQEVLAASTDTQQL 466
                 :.|.....::.:|                                 ||:.:.|..|....
Frog   335 KDGVGILGSPVAVISTVCVYVNKHGNSGPHLDKKKVLQLPDHFGPGPVNVVLQQAVQACVDCAYY 399

  Fly   467 SKLLFALEGDVH----IVTAA--GKNFTVKIPSPMRMKDDESLAQFIETLCTTCRACANLISL-- 523
            ||::|:.....|    .:||:  |:..:|.:|.   :.....:.:|:|.||.:.: |.||.|.
Frog   400 SKIVFSFLKSGHHGGEAITASFDGEKHSVHLPP---VNSASFVLRFLEKLCHSLQ-CDNLFSSQP 460

  Fly   524 -------VHETEECKKCANSRKRQLTQSAT-------PPSSPVLADKRNRQSNSATTSPSEKIIK 574
                   .|...:..: :.:.|.::|..:.       ||.|..|:.|..|    :...|.|
Frog   461 FSPHMGGAHSPTDYDR-SKTTKEEITDRSNKRYCQDPPPFSAPLSPKLPR----SEVHPPE---- 516

  Fly   575 QELAVKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASKSSNKVVIKSEPNGANAQTSSTTQ 639
               |..||.|....        |..|:.|..|:::..|:.             |.|:..|.:||:
Frog   517 ---AEMSPTEENCM--------PKDQRFSEESMDSALNTV-------------NTASPATRNTTE 557

  Fly   640 ALRKVRFQHHANTNTNSSATNGN-QDTSQTTHVSTSHCSSSSTSSSTSLAGGSANTSTIGKYLAP 703
                     :.|....|:...|: |..:.|::.:.....|||:|:|.|
Frog   558 ---------YRNMGATSAYYRGSVQPVTATSNGAPVVRRSSSSSASNS----------------- 596

  Fly   704 LVAEVHPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQSASSTALAAGGVTAAKAATAPA 768
                            .||.|....:...            .::||||
Frog   597 ----------------CYYDSSRNRTQRR------------IEAASST----------------- 616

  Fly   769 GAAATAGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEVIQYI-ESNDNSLAVHGDLFRKH 832
                           |.|....|.......|...|..|::::|:.:: |::..:||.|.:|||:|
Frog   617 ---------------TGPELHSTERQTTQSLSKDPATWSVDDVMCFVKEADPQALAPHAELFRRH 666

  Fly   833 EIDGKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            ||||.|||||.|:|:|||||||||||||:|..:.::
Frog   667 EIDGTALLLLRSDMIMKYMGLKLGPALKLCYHIERL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	67/94 (71%)
		MBT	<312..382	CDD:214723	45/69 (65%)
		DUF3588	418..524	CDD:288954	30/171 (18%)
		SAM_Scm	800..870	CDD:188977	36/70 (51%)
		SAM	806..867	CDD:197735	35/61 (57%)
scml2	XP_012812742.2	MBT	17..112	CDD:214723	67/94 (71%)
		MBT	123..221	CDD:214723	57/97 (59%)
		RBR	255..316	CDD:407329	10/64 (16%)
		SLED	350..459	CDD:403384	22/112 (20%)
		SAM_Scm	633..704	CDD:188977	36/70 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5779
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123551at33208
OrthoFinder	1	1.000	-	-		FOG0005433
OrthoInspector	1	1.000	-	-		otm48099
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4747
SonicParanoid	1	1.000	-	-		X2741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190