DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and SFMBT2

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001018049.1	Gene:	SFMBT2 / 57713	HGNCID:	20256	Length:	894	Species:	Homo sapiens

Alignment Length:	928	Identity:	194/928 - (20%)
Similarity:	316/928 - (34%)	Gaps:	266/928 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 GSASGKGLAESERKLLASGAPAPTGPFQYESFHVFDWDAYLEETGSEAAPAKCFKQAQNPPNNDF 205
            |||:|.|..:||.    ..:...||         |:|..||||||:.|||...||..:....::|
Human    23 GSANGNGDLDSEE----GSSLEETG---------FNWGEYLEETGASAAPHTSFKHVEISIQSNF 74

  Fly   206 KIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRL--DGSDSQNDFWRLVDSTEIHAIGHCEKNGG 268
            :.|||||..:..|..:..:||::...|..|.||.  .|.|.:.|||..|...::|.:|.|.:|..
Human    75 QPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVVIADLHPVGWCTQNNK 139

  Fly   269 MLQPPLGFRMNASSWPGYLCKILNNAMVAPEEIFQ-PEPPEPEENLFKVGQKLEAVDKKNPQLIC 332
            :|.||...:...:.|..:|.:.|..:..||..:.: |...:...:|..||..:|..|.:||....
Human   140 VLMPPDAIKEKYTDWTEFLIRDLTGSRTAPANLLEGPLRGKGPIDLITVGSLIELQDSQNPFQYW 204

  Fly   333 CATVDAIKDDQIHVTFDGWRG--AFDYWCNYRSRDIFPAGWCARSCHPMQPPG--HKSRMDSSSS 393
            ..:|......::.:.:.|...  ::|.|..|....:.|.|||..:.:.|.||.  :..:|   :|
Human   205 IVSVIENVGGRLRLRYVGLEDTESYDQWLFYLDYRLRPVGWCQENKYRMDPPSEIYPLKM---AS 266

  Fly   394 KQRCPRPRYTVVAESEAMVPASPATAHFHPNCKGGPFINNSKL------------PCMVT----- 441
            :.:|...:..:.|   |..|........|.:.:...|....||            |..||
Human   267 EWKCTLEKSLIDA---AKFPLPMEVFKDHADLRSHFFTVGMKLETVNMCEPFYISPASVTKVFNN 328

  Fly   442 ----------GPTYQTLAKLCLQEVLAASTDTQQLSKLLFALEGDVHIV---------------- 480
                      .|....|:.||       ..|:..:..:.:.|:..|.:.
Human   329 HFFQVTIDDLRPEPSKLSMLC-------HADSLGILPVQWCLKNGVSLTPPKGYSGQDFDWADYH 386

  Fly   481 ---------------TAAGKNFT-----------------------------------VKIPSPM 495
                           |:..:.||                                   ::.|.|.
Human   387 KQHGAQEAPPFCFRNTSFSRGFTKNMKLEAVNPRNPGELCVASVVSVKGRLMWLHLEGLQTPVPE 451

  Fly   496 RMKDDESLAQFIETLCTTCRACANLISLVHETEECKKCANSRKRQLTQ--SATPPSSPVLADKRN 558
            .:.|.||:..|   ....|.|.:..::..|:|...||    ||..:.|  ...||:.||
Human   452 VIVDVESMDIF---PVGWCEANSYPLTAPHKTVSQKK----RKIAVVQPEKQLPPTVPV------ 503

  Fly   559 RQSNSATTSPSEKIIKQELAVKSPVESKSKTSTNNGKEPASQQNSNHS------LNNNN-----N 612
                        |.|..:|.:...:::   |.|.|||....|...||.      ||...     .
Human   504 ------------KKIPHDLCLFPHLDT---TGTVNGKYCCPQLFINHRCFSGPYLNKGRIAELPQ 553

  Fly   613 SASKSSNKVVIKSEPNGANAQTSSTTQALRKVRFQHHANTN----TNSSATNGNQDTSQTTHVST 673
            |.......:|:|...:..........:.||:::.....:.|    |..:...|....:....|.|
Human   554 SVGPGKCVLVLKEVLSMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKIVRT 618

  Fly   674 S--------------------------------HCSSSSTSSSTSLAGGSANTSTIGKYLAPLVA 706
            |                                :||..:.:..|...|.....|      .|.:.
Human   619 SDQVANFCRRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKIS------KPPIG 677

  Fly   707 EVHPEQANVKP-----------------------------------------------SNSYYKS 724
            |.:|:..:.||                                               :.|..:.
Human   678 ESNPDSGHPKPARRRKRRKSIFVQKKRRSSAVDFTAGSGEESEEEDADAMDDDTASEETGSELRD 742

  Fly   725 PTTLSSSASLPTSVSTPFTGCQSASSTALAAGGVTAAKAATAPAGAAATAGAS-PSYTAITSPVS 788
            ..|.:|||.:|::........:|.|............:...|||.::|..|.. |.    |.|..
Human   743 DQTDTSSAEVPSARPRRAVTLRSGSEPVRRPPPERTRRGRGAPAASSAEEGEKCPP----TKPEG 803

  Fly   789 TPTSALANSH---LRSQPIDWTIEEVIQYIESNDNSLAVHGDLFRKHEIDGKALLLLNSEMMMKY 850
            |..:......   |.|.|::||:.:|:::|:..|  .|....:|::.:|||:|||||....:.:.
Human   804 TEDTKQEEEERLVLESNPLEWTVTDVVRFIKLTD--CAPLAKIFQEQDIDGQALLLLTLPTVQEC 866

  Fly   851 MGLKLGPALKICNLVNKV 868
            |.||||||:|:|:.:.:|
Human   867 MELKLGPAIKLCHQIERV 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	35/96 (36%)
		MBT	<312..382	CDD:214723	17/71 (24%)
		DUF3588	418..524	CDD:288954	25/198 (13%)
		SAM_Scm	800..870	CDD:188977	27/69 (39%)
		SAM	806..867	CDD:197735	24/60 (40%)
SFMBT2	NP_001018049.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		7/19 (37%)
		MBT 1	44..144		37/99 (37%)
		MBT	48..144	CDD:214723	35/95 (37%)
		MBT 2	152..256		23/103 (22%)
		MBT	156..256	CDD:214723	22/99 (22%)
		MBT 3	266..372		19/115 (17%)
		MBT	276..372	CDD:214723	17/105 (16%)
		MBT 4	380..477		11/99 (11%)
		MBT	384..477	CDD:214723	11/95 (12%)
		SLED	528..643	CDD:403384	16/114 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..813		23/150 (15%)
		SAM_Scm-like-4MBT1,2	810..894	CDD:188980	28/77 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810