DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and scml2

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_009304396.1	Gene:	scml2 / 559561	ZFINID:	ZDB-GENE-130530-546	Length:	723	Species:	Danio rerio

Alignment Length:	871	Identity:	283/871 - (32%)
Similarity:	377/871 - (43%)	Gaps:	291/871 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 KHQKKNCSTRHSGGSASGKGLAESERKLLASGAPAPTGPFQYESFHVFDWDAYLEETGSEAAPAK 192
            ||.|:. |.|::..|...:.|.|:                       |.|:.||.||.|..|...
Zfish    10 KHHKEK-SGRNNEDSQPSQKLTEA-----------------------FSWEMYLRETSSCPASPS 50

  Fly   193 CFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDSQNDFWRLVDSTEI 257
            ||:|::.||.|||::|||:||.||||.:|.|||||:|::|.|||||||||||.||||||||:.:|
Zfish    51 CFRQSRVPPANDFRVGMKVEACDPRNASSWCIATVMGLMGVRLRLRLDGSDSTNDFWRLVDAADI 115

  Fly   258 HAIGHCEKNGGMLQPPLGFRMNASSWPGYLCKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEA 322
            ..||.|||:|.||||||||||||||||.:|.|.|:.|.:||...|:.|||.|.:|.||.|.||||
Zfish   116 QPIGTCEKSGDMLQPPLGFRMNASSWPMFLLKTLSGAEMAPSSAFKKEPPRPTQNFFKAGMKLEA 180

  Fly   323 VDKKNPQLICCATVDAIKDDQIHVTFDGWRGAFDYWCNYRSRDIFPAGWCARSCHPMQPPGH--- 384
            ||:|||.|||.||:..::.|:|.:.||||||||||||.:.||||||.|||..:.|.:||||:
Zfish   181 VDRKNPYLICPATIGEVRGDKIFIMFDGWRGAFDYWCQFDSRDIFPVGWCQLTNHSLQPPGNCFT 245

  Fly   385 --KSRMDSSS----------SKQRCP---------------RPRYTVVAESEAMVPAS------- 415
              |:.:.|.|          |..|.|               ||:...:|..:|...|:
Zfish   246 IPKTLLPSVSRPSPSWRPMQSPYRLPHPLPPLPVRKGVRGRRPKSQTIAMLKAAAEAAAAGNSPS 310

  Fly   416 ------PATAHFHPNC---------KGGPFINNS---KLPCMVTGP------------TYQT--- 447
                  |.:||..|..         |.||...:.   |:|..::.|            :.||
Zfish   311 QNGQSQPTSAHKSPISSPLTPKPYKKRGPKPGSKRKPKVPHSLSSPILSSSVSDGRLSSLQTTRD 375

  Fly   448 ---LAKLC---------------------------------LQEVLAASTDTQQLSKLLFAL--- 473
               ::.:|                                 ||..:.|..|.....|.||:.
Zfish   376 SGVVSTVCVYVNKHGNSGPHLDRKLLLQLPDHFGPGPVNTVLQHAVQACVDCAFQPKALFSFLQS 440

  Fly   474 ------------EGDVHIV---TAAGKNFTVKIPSPMRMKDDESLAQFIETLCTTCRACANLISL 523
                        ||.:|.|   ||:..:|.::               |:||||...: |.||.|
Zfish   441 QSDGGEIIRVRSEGGIHYVKLPTASSASFVLR---------------FLETLCHHLQ-CDNLFS- 488

  Fly   524 VHETEECKKCANSRKRQLTQSATPPSSPVLADKRNRQSNSATTSPSEKIIKQELAVKSPVESKSK 588
                                  :.|.||:         .|:|.:|.|               :||
Zfish   489 ----------------------SQPFSPL---------TSSTHTPYE---------------RSK 507

  Fly   589 TSTNNGKEPASQQNSNHSLNNNNNSASKS-SNKVVIKSEPNGANAQTSSTTQALRKVRFQHHANT 652
            :......|..|........|.::::.|.: |.|:              ..|:||        .:.
Zfish   508 SVKEETSEALSVARGTRRFNRDSSAYSTALSPKL--------------QRTEAL--------PSD 550

  Fly   653 NTNSSATNGNQDTSQTTHVSTSHCSSSSTSSSTSLA-GGSANTSTIGKYLAPLVAEVHPEQANVK 716
            .|.:.|.||.....|       ....|..|:|.|:| ...|:.||         :|.|....
Zfish   551 ETIAHAENGASTEQQ-------FLEESMDSASKSVAPRPPAHRST---------SEFHTPTG--- 596

  Fly   717 PSNSYYKS-PTTLSSSASLPTSVST--PFTGCQSASSTALAAGGVTAAKAATAPAGAAATAGASP 778
             |:.:|.| |..|...:|.|....|  ...|..|||||             |.|...|..  ..|
Zfish   597 -SSPHYPSHPPLLRGLSSNPAEPRTHRRVEGRLSASST-------------TGPDHQATE--KDP 645

  Fly   779 SYTAITSPVSTPTSALANSHLRSQPIDWTIEEVIQYIESND-NSLAVHGDLFRKHEIDGKALLLL 842
            |.|:..||.|                 |:||||:|::...| .:|..|.:||||||||||||:||
Zfish   646 SKTSNKSPSS-----------------WSIEEVMQFVRDADPQALGPHAELFRKHEIDGKALMLL 693

  Fly   843 NSEMMMKYMGLKLGPALKICNLVNKV 868
            .|:|:|||||||||||||:|:.:.|:
Zfish   694 RSDMIMKYMGLKLGPALKLCHHIEKL 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	60/94 (64%)
		MBT	<312..382	CDD:214723	43/69 (62%)
		DUF3588	418..524	CDD:288954	35/186 (19%)
		SAM_Scm	800..870	CDD:188977	40/70 (57%)
		SAM	806..867	CDD:197735	39/61 (64%)
scml2	XP_009304396.1	MBT	36..131	CDD:214723	60/94 (64%)
		MBT	142..240	CDD:214723	55/97 (57%)
		DUF3588	381..490	CDD:288954	24/147 (16%)
		SAM_Scm	650..721	CDD:188977	43/87 (49%)
		SAM	653..722	CDD:197735	42/84 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6815
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1891
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123551at33208
OrthoFinder	1	1.000	-	-		FOG0005433
OrthoInspector	1	1.000	-	-		otm24432
orthoMCL	1	0.900	-	-		OOG6_105988
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4747
SonicParanoid	1	1.000	-	-		X2741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.090