DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and sfmbt2

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_005164891.1	Gene:	sfmbt2 / 555450	ZFINID:	ZDB-GENE-041210-196	Length:	861	Species:	Danio rerio

Alignment Length:	881	Identity:	192/881 - (21%)
Similarity:	311/881 - (35%)	Gaps:	226/881 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 FDWDAYLEETGSEAAPAKCFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRL 239
            |:|:.|||:||:.|||...|:..:....:.|:.|||||..:..:|.:..:||::...|..|.||.
Zfish    10 FNWEEYLEDTGATAAPHTSFRHVELSLQSSFQPGMKLEVANKGSVDTYWVATIITTCGQLLLLRY 74

  Fly   240 --DGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQPP-------LGFRMNASSWPGYLCKILNNAM 295
              .|.|.:.|||..|.:.|:|.:|.|.:|...||||       ...:...|.|..:|.|.|..:.
Zfish    75 CGYGEDRKADFWCDVMTAELHPVGWCAQNDKTLQPPEDNVYLRAAIKEKYSDWTEFLIKELTGSR 139

  Fly   296 VAPEEIFQ-PEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWRGAFDY-W 358
            .||..:.: |...:...:|...|..||..|...|.:.....|......::.:::.|......| |
Zfish   140 TAPANLLEGPLRGKNTVDLIMEGSILELRDASEPSVYWATQVQRNVGGRLCLSYVGLNDPSYYMW 204

  Fly   359 CNYRSRDIFPAGWCARSCHPMQPPGHKSRMDSSSSKQRCPRPRYTVV---AESEAMVPASP---- 416
            ..|....:.|.||...:..||:||.....:.|||        .:|..   |.:||:....|
Zfish   205 MFYLDTRLRPLGWAKENNLPMKPPTDLCDLRSSS--------EWTTALDEATAEALNNPLPLEVF 261

  Fly   417 ---ATAHFHPNCKGGPFINNSKL------------PCMVTGPTYQTLAKLCLQEVLAASTDTQQL 466
               |..|.|      .|....||            |..||....:...::.:.::.|.:|.|
Zfish   262 KDHADLHTH------SFRAGMKLEMVSPVEPFHICPVSVTKVYNEYHFQITVDDLTADATPT--- 317

  Fly   467 SKLLFALEGDVHIVTAAGKNFTVKIPSPMRMK-DDESLAQFIETLCTTCR--AC----------- 517
            |.:..|....:..|....|| .|::..|...: .|...|.:::...|...  ||
Zfish   318 SAVCHAESPGILPVQWCLKN-GVELERPRGFETQDFDWADYLKHTSTEAAPDACFPNASQSRGFC 381

  Fly   518 ----ANLISLVHETEECKKCANSRKRQL----TQSATPPSSPVLADKRNR--------------- 559
                ...::.:|..|.|.......|..|    .:..|.|....:.|..:.
Zfish   382 KDMWLEAVNPLHPAELCVARITQVKGCLLWLRLEGLTKPLPDCIVDVESMNIFPVGWCEANGYPL 446

  Fly   560 ----------QSNSATTSPSEKI-------IKQELAVKSPVESKSKTSTNNGKEPASQQNSNHS- 606
                      |...|...|.:::       |...|...:|::|    ...|||...||...||.
Zfish   447 THSLKTVCLPQKKIAVVQPEKQLAPSQSPDIPISLCSSAPMDS----GLVNGKYCCSQLFINHRC 507

  Fly   607 -----LNNNN-------------------------NSASKSSNKVVIKSEPNGANAQTSSTTQAL 641
                 ||...                         |||.|...  |::......:.|.:...:.|
Zfish   508 FSGPYLNKGRIAELPKAVGPGKCAVVLKEILTMLINSAYKPGR--VLRELQMVEDPQWNCQEETL 570

  Fly   642 RKVRFQHHANTNTNSSATNGNQ----------------DTSQTTHVS---TSHCSSSSTSSSTSL 687
             |.:::..:..:|.......:|                :....|.||   ..:|||.:.:..|..
Zfish   571 -KAKYKGKSYRSTMRIVRTADQVSEFCRRVCERLQCCLNLFGPTFVSDKCPENCSSQTKTKYTYY 634

  Fly   688 AGGSANTSTIGKYLAPLVAEVHPEQANVKPSN-------------------SYYKSPTTLSSSAS 733
                 ....:|:   |.:.|...:....||:.                   .|:.:.:...|..:
Zfish   635 -----KKRKVGR---PSLGENAQDGDLSKPARRRKKRKAIFVQKKRRSSIVGYHTTESPQDSDYN 691

  Fly   734 LPTSVSTPFT--GCQSASST---------ALAAGGVTAAKAA-----TAPAGAAATAGASPSYTA 782
            ........|.  |.:::||:         :|...|....:||     |.| |:..:...||..|
Zfish   692 YDEDEDEDFEEWGSEASSSSLREEASAHNSLPRRGRPPRRAALQRRMTHP-GSETSDRISPRRT- 754

  Fly   783 ITSPVSTPTSALANSH--------------LRSQPIDWTIEEVIQYIESND-NSLAVHGDLFRKH 832
             |..||...:.:|...              |.:.|:.|::.:|:.:|.|.| .|||   .:|::.
Zfish   755 -TRSVSYSQNQMARDTNVKMESTEEEDRLVLDTNPLQWSVSDVVDFITSTDCASLA---KIFQEQ 815

  Fly   833 EIDGKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            :|||:|||||....:.:.|.||||||:|:|:.:.:|
Zfish   816 DIDGQALLLLTLPTVQECMDLKLGPAIKLCHQIERV 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	35/96 (36%)
		MBT	<312..382	CDD:214723	16/70 (23%)
		DUF3588	418..524	CDD:288954	23/135 (17%)
		SAM_Scm	800..870	CDD:188977	28/70 (40%)
		SAM	806..867	CDD:197735	26/61 (43%)
sfmbt2	XP_005164891.1	MBT	13..110	CDD:214723	35/96 (36%)
		MBT	134..228	CDD:302657	20/93 (22%)
		MBT	277..348	CDD:280910	15/74 (20%)
		MBT	356..447	CDD:214723	11/90 (12%)
		DUF3588	498..612	CDD:288954	16/116 (14%)
		SAM_Scm-like-4MBT1,2	777..861	CDD:188980	29/78 (37%)
		SAM	788..852	CDD:197735	28/67 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810