DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and Sfmbt1

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001160003.1	Gene:	Sfmbt1 / 54650	MGIID:	1859609	Length:	863	Species:	Mus musculus

Alignment Length:	901	Identity:	200/901 - (22%)
Similarity:	302/901 - (33%)	Gaps:	287/901 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CG----------EGKLPLQYVLPTQTGKKEFCSETCIAEFRKAYSKGACTQCDNV---------- 110
            ||          .|:.||..:.|   |.|..|.     :||.:.|....|..:|:
Mouse   142 CGPPVSLLEGLRNGRNPLDLIAP---GSKLECQ-----DFRDSLSTWLVTVVENIGGRLKLRYEG 198

  Fly   111 --IRDGAPN-----KEFCSIMCMNKHQKKNCSTRHSGGSASGKG------LAESERKLLASGAPA 162
              .|||..:     ..|.                |..|.|:.:|      ||....|..|
Mouse   199 LESRDGFEHWLYYLDPFL----------------HHIGWAAQQGCDLQPPLAIKHLKSEA----- 242

  Fly   163 PTGPFQYESFHVFDWDAYLEET-GSEAAPAKCFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIAT 226
                         ||...|.:. ..|..|:..||..|....::|.|.|||||:||.:......||
Mouse   243 -------------DWQEILAKVKEEEPLPSYLFKDKQVIGTHEFSINMKLEAVDPWSPFGISPAT 294

  Fly   227 VVGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHAIGHCE-----------KNGGMLQPPLGFRMNA 280
            :..|...:..|      .:.|..|..|.|....:.|..           |||..:.||.|||...
Mouse   295 IAKVFDDKYFL------VEMDDLRPEDHTRRSFVCHANSPGIFPVQWSLKNGLHINPPPGFRSQD 353

  Fly   281 SSWPGYL--CKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQ 343
            ..|..||  |    .|..||::.|   |....|:.||...|||||:...|:.:|.|||.|::...
Mouse   354 FDWADYLKQC----GAEAAPQKCF---PQSISEHQFKENMKLEAVNPLFPEEVCIATVTAVRGSY 411

  Fly   344 IHVTFDGWRGAF-DYWCNYRSRDIFPAGWCARSCHPMQPP----GHKSR---------------- 387
            :.:..:|.:... ::..:..|.:|||.|||..:.||:..|    |||.|
Mouse   412 LWLQLEGSKKPVPEFIVSAESMNIFPLGWCETNGHPLSTPRRARGHKLRKIAVVQPEKQILSSRT 476

  Fly   388 --------MDSSSS-----KQRCPRPRYTVVAESEAMVPASPATAHFHPNCKGGPFINN---SKL 436
                    ::|:.|     |..||:                   .:|:..|..||::|.   ::|
Mouse   477 VHEGLKNQLNSTHSVMINGKYCCPK-------------------IYFNHRCFSGPYLNKGRIAEL 522

  Fly   437 PCMVTGPTYQTLAKLCLQEVL-----AASTDTQQLSKLLFALE------GDVHIVTAAGKNF--T 488
            |..| ||..   ..|.|:|||     ||...::.|.:|....:      |:|......||::  |
Mouse   523 PQCV-GPGN---CVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRAT 583

  Fly   489 VKIPSPMRMKDDESLAQFIETLCTTCRACANLISLVHETEEC-KKCANSRKRQLTQSATPPSSPV 552
            |:|     ::..:.:.:|....|.....|.||.......:.| :.|:...|.:.|.        .
Mouse   584 VEI-----VRTADRVTEFCRQTCIKLECCPNLFGPRMVLDTCSENCSVLTKTKYTH--------Y 635

  Fly   553 LADKRNRQSNSATTSPSEKIIKQELAVKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASKS 617
            ...|:|::.                                |:.|....|.:.:|..::....:.
Mouse   636 YGKKKNKRI--------------------------------GRPPGGHSNLSCALKKSSKRRKRR 668

  Fly   618 SNKVVIKSEPNGANAQTSSTTQALRKVRFQHHANTNTNSSATNGNQDTSQTTHVSTSHCSSSSTS 682
            .|..|.|.:.:.|:..                 ||...|...:|.:|............:..|||
Mouse   669 KNIFVHKKKRSSASVD-----------------NTPVGSPQGSGGEDEEDADDGDEDSLTEGSTS 716

  Fly   683 SSTSLAGGSANTSTIGKYLAPLVAEVHPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQS 747
            ..                     .|...|::.|....|...|||...:...||....|.....|
Mouse   717 EQ---------------------QEELQEESEVSEKKSSSSSPTQSETPTPLPPDTQTNKRDAQ- 759

  Fly   748 ASSTALAAGGVTAAKAATAPAGAAATAGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEVI 812
                                     |:..|.......||...........||.|.|:.|::.:|:
Mouse   760 -------------------------TSSVSDDENKPPSPKEIRIEVDERLHLDSNPLKWSVADVV 799

  Fly   813 QYIESNDNSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            ::|.|.|  .|....:|...||||:|||||....:.:.|.||||||:|:|:.:.::
Mouse   800 RFIRSTD--CAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERI 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998	9/38 (24%)
		MBT	178..273	CDD:214723	27/106 (25%)
		MBT	<312..382	CDD:214723	23/70 (33%)
		DUF3588	418..524	CDD:288954	31/121 (26%)
		SAM_Scm	800..870	CDD:188977	27/69 (39%)
		SAM	806..867	CDD:197735	25/60 (42%)
Sfmbt1	NP_001160003.1	MBT 1	20..120
		MBT	23..120	CDD:214723
		MBT 2	128..232		22/113 (19%)
		MBT	132..232	CDD:214723	22/113 (19%)
		MBT 3	242..346		30/127 (24%)
		MBT	245..346	CDD:214723	27/106 (25%)
		MBT 4	354..451		33/103 (32%)
		MBT	358..451	CDD:214723	32/99 (32%)
		SLED	499..614	CDD:371916	33/142 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..773		31/230 (13%)
		SAM_Scm-like-4MBT1,2	779..863	CDD:188980	29/77 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810