Protein Alignment Scm and SFMBT1

DIOPT Version :10

• Sequence 1: NP_731385.1
• Gene: Scm / 41168
• FlyBaseID: FBgn0003334
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: NP_057413.2
• Gene: SFMBT1 / 51460
• HGNCID: 20255
• Length: 866
• Species: Homo sapiens
• Alignment Length: 747
• Identity: 177/747 - (23%)
• Similarity: 268/747 - (35%)
• Gaps: 187/747 - (25%)

  Fly   176 DWD---AYLEETGSEAAPAKCFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRL 237
            :|.   |.::|...|..|:..||..|....:.|.:.|||||:||.:......||||.|...:..|
Human   243 EWQEILAKVKEEEEEPLPSYLFKDKQVIGIHTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFL 307

  Fly   238 -RLDGSDSQN----DFWRLVDSTEIHAIGHCEKNGGMLQPPLGFRMNASSWPGYL--CKILNNAM 295
             .:|....:|    .|....||..|..:....|||..:.||.|:......|..||  |    .|.
Human   308 VEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQDFDWADYLKQC----GAE 368

  Fly   296 VAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWRGAF-DYWC 359
            .||:..|   ||...|:.||...|||||:...|:.:|.||:.|::...:.:..:|.:... :...
Human   369 AAPQRCF---PPLISEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIV 430

  Fly   360 NYRSRDIFPAGWCARSCHPMQPPGHKSRMDSSSSKQRCPRPRYTVVAESEAMVPASPATAH---- 420
            :..|.||||.|||..:.||:..|          .:.|..:.|...|.:.|..||:| .|.|
Human   431 SVESMDIFPLGWCETNGHPLSTP----------RRARVYKQRKIAVVQPEKQVPSS-RTVHEGLR 484

  Fly   421 ----------------------FHPNCKGGPFINN---SKLPCMVTGPTYQTLAKLCLQEVL--- 457
                                  |:..|..||::|.   ::||..| ||..   ..|.|:|||
Human   485 NQELNSTESVMINGKYCCPKIYFNHRCFSGPYLNKGRIAELPQCV-GPGN---CVLVLREVLTLL 545

  Fly   458 --AASTDTQQLSKLLFALE------GDVHIVTAAGKNF--TVKIPSPMRMKDDESLAQFIETLCT 512
              ||...::.|.:|....:      |:|......||::  ||:|     :|..:.:.:|....|.
Human   546 INAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRATVEI-----VKTADRVTEFCRQTCI 605

  Fly   513 TCRACANLISLVHETEEC-KKCANSRKRQLTQSATPPSSPVLADKRNRQSNSATTSPSEKIIKQE 576
            ....|.||.......::| :.|:...|.:.|.        ....|:|::.
Human   606 KLECCPNLFGPRMVLDKCSENCSVLTKTKYTH--------YYGKKKNKRI--------------- 647

  Fly   577 LAVKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASKSSNKVVIKSEPNGANAQTSSTTQAL 641
                             |:.|....|...:|...:....:..|..|.|.:.:.|:..
Human   648 -----------------GRPPGGHSNLACALKKASKRRKRRKNVFVHKKKRSSASVD-------- 687

  Fly   642 RKVRFQHHANTNTNSSATNGNQDTSQTTHVSTSHCSSSSTSSSTSLAGGSANTSTIGKYLAPLVA 706
                     ||...|...:|.:|............|..|||....
Human   688 ---------NTPAGSPQGSGGEDEDDPDEGDDDSLSEGSTSEQQD-------------------- 723

  Fly   707 EVHPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQSASSTALAAGGVTAAKAATAPAGAA 771
            |:. |::.:....|...|||....|.|||..        :......|
Human   724 ELQ-EESEMSEKKSCSSSPTQSEISTSLPPD--------RQRRKREL------------------ 761

  Fly   772 ATAGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEVIQYIESNDNSLAVHGDLFRKHEIDG 836
            .|...|.......||...........||.|.|:.|::.:|:::|.|.|  .|....:|...||||
Human   762 RTFSFSDDENKPPSPKEIRIEVAERLHLDSNPLKWSVADVVRFIRSTD--CAPLARIFLDQEIDG 824

  Fly   837 KALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            :|||||....:.:.|.||||||:|:|:.:.::
Human   825 QALLLLTLPTVQECMDLKLGPAIKLCHHIERI 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_731385.1	zf-FCS	58..95	CDD:428958
		MBT_dScm_rpt1	196..294	CDD:439097	31/104 (30%)
		MBT_dScm_rpt2	312..383	CDD:439100	23/71 (32%)
		SLED	418..522	CDD:463469	34/145 (23%)
		SAM_Scm	800..870	CDD:188977	27/69 (39%)
SFMBT1	NP_057413.2	MBT 1	20..120
		Antigenic epitope	34..42
		MBT_SFMBT1_rpt1	47..140	CDD:439101
		MBT 2	128..232
		MBT_SFMBT1_rpt2	159..257	CDD:439103	3/13 (23%)
		MBT 3	242..348		31/104 (30%)
		MBT_SFMBT1_rpt3	273..366	CDD:439105	30/96 (31%)
		MBT 4	356..453		34/103 (33%)
		MBT_SFMBT1_rpt4	382..471	CDD:439107	27/98 (28%)
		SLED	502..617	CDD:463469	32/123 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	641..777		33/231 (14%)
		SAM_Scm-like-4MBT1,2	782..866	CDD:188980	29/77 (38%)