DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and ph-d

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_524794.2	Gene:	ph-d / 44889	FlyBaseID:	FBgn0004860	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	702	Identity:	136/702 - (19%)
Similarity:	230/702 - (32%)	Gaps:	241/702 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 KSRMDSSSSKQRCPRPRYTVVAESEAMVPASPATA---HFHPNCKGG-------PFINNSKLPCM 439
            ::::.:.:.:|:..|.:...:.:...:..::.||:   ...|..:.|       ||   |..|.|
  Fly   849 QAQVQAQAQQQQQQREQQQNIIQQIVVQQSTGATSQQQQQQPQQQSGQLQLSSVPF---SVSPSM 910

  Fly   440 VTGPTYQTLAKLCLQEVLAASTDTQQLSKLLFALEGDVHIVTAAGKNFTVKIPSPMRMKDDESLA 504
             |......:....|||.|:.|....|.:|.:......  :.|::....|.:..:|:......:..
  Fly   911 -TAEDIAGITSSALQEALSVSGAIFQTTKPITCSSST--LPTSSVVTITSQSSTPLVTSSTVASM 972

  Fly   505 QFIETLCTTCRACANLISLVHETEECKKCANSRKRQLTQ----------SATPPSSPVLA--DKR 557
            |..:|..|.......|||       ......|:::|..|          :.:|.::|:||  ...
  Fly   973 QQAQTQGTQIHQHQQLIS-------ATIAGGSQQQQQQQQLGLPSLTPTTPSPTTNPILAMTSMM 1030

  Fly   558 NRQ------------SNSATTSPSEKIIKQELA------------------------------VK 580
            |..            |::|.|..|.:::....|                              .|
  Fly  1031 NATVGHLSTAPPVSVSSTAVTPSSGQLVTLSSASSGGGAGFPATPTKETPSKGPTATLVPIDSPK 1095

  Fly   581 SPVESKSKTSTNNGKEPA-------SQQNSNHSLNNNNNS-------------ASKSSNKVV--- 622
            :||..|...:|.....||       :..::..:|:|.:.|             .||.||..|
  Fly  1096 TPVSGKDTCTTPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPP 1160

  Fly   623 ---IKSEPNGANAQTSSTTQALRKVRFQHHANTNTNSSATNG----------NQDTSQTTHVS-- 672
               |.:..:|......:|..:|...     .:|:|.::.|||          ...|:.||..|
  Fly  1161 SSTIPNSVSGKEEPKLTTCGSLTSA-----TSTSTTTTITNGIGVARTTASTAVSTASTTTTSSG 1220

  Fly   673 --TSHCSSSSTSSSTSLAGGSAN-----------TSTIGKYLAPLVAEVHP----EQANVKPSNS 720
              |:.|:|::|::::|::.||.:           |..|..::.....|..|    ..|:...|:.
  Fly  1221 TFTTSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDE 1285

  Fly   721 YYKSPTTLSSSASLPTSVSTPFT-------------------------GCQ-----------SAS 749
            ..|...|:.....|....|.|.:                         ||.           |..
  Fly  1286 PPKKKATMQEDIKLSGIASAPGSDMVACEQCGKMEHKAKLKRKRYCSPGCSRQAKNGIGGVGSGE 1350

  Fly   750 STALAAGGVTAAKA-------------------------------ATAP-------AGAAATAGA 776
            :..|..||:....|                               |..|       ...||.:.:
  Fly  1351 TNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTESYQTVSDALPIQAATPEVPPISMPVLAAMSTS 1415

  Fly   777 SPSYTAITSP-----------------VSTPTSALANSHLRSQ---PI-DWTIEEVIQYIES--- 817
            ||....:|.|                 |..|..|:.:|::...   || .|::|||..:|..
  Fly  1416 SPLSLPLTLPLPIAIAPTVSLPVVSAGVVAPVLAIPSSNINGSDRPPISSWSVEEVSNFIRELPG 1480

  Fly   818 -NDNSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
             .|     :.|.|.:.||||:|||||....::..||:||||||||...|..:
  Fly  1481 CQD-----YVDDFIQQEIDGQALLLLKENHLVNAMGMKLGPALKIVAKVESI 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723
		MBT	<312..382	CDD:214723
		DUF3588	418..524	CDD:288954	25/115 (22%)
		SAM_Scm	800..870	CDD:188977	30/77 (39%)
		SAM	806..867	CDD:197735	28/64 (44%)
ph-d	NP_524794.2	SAM_Ph1,2,3	1461..1529	CDD:188976	30/72 (42%)
ph-d	NP_524794.2	SAM	1464..1529	CDD:197735	28/69 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453490
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840