DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scm and Sfmbt2

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001185737.1	Gene:	Sfmbt2 / 353282	MGIID:	2447794	Length:	975	Species:	Mus musculus

Alignment Length:	1037	Identity:	216/1037 - (20%)
Similarity:	335/1037 - (32%)	Gaps:	372/1037 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 MNKHQKKNCSTRHSGGSASGKGLAESERKLLASGAPAPTGPFQYESFHV----FDWDAYLEETGS 186
            ::|.:..:.|.....|||:|.|...||                 |..::    |.|..||||||:
Mouse     7 VSKKRNSSSSLEKITGSANGNGTLYSE-----------------EDTNLEENDFSWGDYLEETGT 54

  Fly   187 EAAPAKCFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRL--DGSDSQNDFW 249
            .|.|...|:..:....::|:.|||||..:..|..:..:||::...|..|.||.  .|.|.:.|||
Mouse    55 RAVPHVSFRHVEISIRSNFQPGMKLEVANKNNPDTYWVATIITTCGQLLLLRYCGYGEDRRADFW 119

  Fly   250 RLVDSTEIHAIGHCEKNGGMLQPPLGFRMNASSWPGYLCKILNNAMVAP---------------- 298
            ..|...::|.:|.|.:|..:|:||...:...|.|..:|.:.|..:..||
Mouse   120 CDVIIADLHPVGWCTQNNKVLRPPDAIKDKYSDWTDFLIRELTGSRTAPANLLEGPLRGKGPIDL 184

  Fly   299 --------------------------------------------------------------EEI 301
                                                                          |..
Mouse   185 ITVDSLIELQDSQNPFQYWIVSVTENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQENK 249

  Fly   302 FQPEPP----------------------------------------------------------- 307
            ::.:||
Mouse   250 YRMDPPSELYYLKLPFEWKCALEKALVLAAESPLPMEVFKDHADLQSHFFTVGMRLETLHISDPF 314

  Fly   308 -----------------------EPE--------------------------------------- 310
                                   .||
Mouse   315 HIYPASVTKVFNSKFFQVAIDDLRPEADKPTMLCHADSLGILPVQWCLKNGVNLAPPKGYSGQDF 379

  Fly   311 -------------------ENLFKVG----QKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWR 352
                               :|.|..|    .|||||:..||..:|.|||.::|...:.:..:|..
Mouse   380 NWVDYHKQRQAEEAPHFCFKNAFSRGFSKNMKLEAVNPVNPGEVCVATVVSVKGRLLWLHLEGLE 444

  Fly   353 GAF-DYWCNYRSRDIFPAGWCARSCHPMQPPGHKSRMDSSSSKQR-----------CPRPRYTVV 405
            ... |...:..|.||||.|||..:.:|:..| :|:   ||.||::           .|.|...:.
Mouse   445 TPMPDIIVDMDSMDIFPVGWCEANSYPLTTP-YKA---SSKSKRKTVHFKMEKQLLSPVPIEKIP 505

  Fly   406 AESEAMVPA--SPATA----------HFHPNCKGGPFINN---SKLPCMVTGPTYQTLAKLCLQE 455
            .|...:.|.  ||..|          ..:..|..|||:|.   |:||..| ||   .:..|.|:|
Mouse   506 HELCLLPPQMDSPVGAINAKYCCPQLFVNHRCFSGPFLNKGRISELPQSV-GP---GMCVLVLKE 566

  Fly   456 VLAASTD-TQQLSKLLFALE--------GDVHIVTA--AGKNF--TVKIPSPMRMKDDESLAQFI 507
            :|...|: ..:..::|..|:        ....|:.|  .||.:  .|||     ::..:.:..|.
Mouse   567 ILTLITNAAYKPGRVLRELQLVEDPEWNSQEEILKAKYGGKTYRAVVKI-----VRTADQVMNFC 626

  Fly   508 ETLCTTCRACANLIS--LVHET--EECKKCANSR--KRQLTQSATPPSSPVLADKRNRQSNSATT 566
            ..:|.....|.||:|  |:.||  |.|.....:|  ||:...|.:|.|     :.::..::.||.
Mouse   627 RQVCAKLECCPNLLSPVLISETCPENCSVHTKTRYNKREKGSSLSPAS-----ELKDDSASHATK 686

  Fly   567 SPSEKI------------IKQELAVKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASKSSN 619
            ....||            |:..|.| |.:|:..| ||...|...|......          :.|.
Mouse   687 LQKAKIPQTYYYGKRRRVIQSSLRV-SNIETPPK-STRRRKRRKSVYVQKR----------RKSA 739

  Fly   620 KVVIKSEPNGANAQTSSTTQALRKVRFQHHANTNTNSSATNGNQDTSQTTHVSTSHCSSSSTSSS 684
            .||....|.|..|.......|    ........:...|...|         :..|...|...:..
Mouse   740 IVVPAGVPAGVPAGVPEDIPA----GIPEGIPASIPESIPEG---------IPESLPESLPEAIP 791

  Fly   685 TSLAGGSANTSTIGKYLAPLVAEVHPEQANVKPSNSYYKSPT--TLSSSASLPTSVSTPFTGCQS 747
            .|:..|||..:...|          .|..:.....:.|..|.  |.:|:|.:      ||...:.
Mouse   792 ESIPKGSAQKTEQEK----------RETLDTARKKTGYHGPAYQTDTSAAQV------PFARPRR 840

  Fly   748 A-----SSTALAAGGV-TAAKAATAPAGAAATAGASPSYTAITSPVSTPTSALANSHLRSQPIDW 806
            |     :|.||....| .|.:..|.|..|::..........|..|..:..|......|.|.|::|
Mouse   841 AVTLRRNSEALKRPPVERARRVRTVPTTASSNNRVKGPLVRIVKPEDSSQSDEEKLILESNPLEW 905

  Fly   807 TIEEVIQYIESNDNSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            ::.:|:::|:..|  .|....:|::.:|||:|||||....:.:.|.||||||:|:|:.:.:|
Mouse   906 SVTDVVRFIKLTD--CAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERV 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	33/96 (34%)
		MBT	<312..382	CDD:214723	26/74 (35%)
		DUF3588	418..524	CDD:288954	32/133 (24%)
		SAM_Scm	800..870	CDD:188977	26/69 (38%)
		SAM	806..867	CDD:197735	23/60 (38%)
Sfmbt2	NP_001185737.1	MBT	47..143	CDD:214723	33/95 (35%)
		MBT	155..255	CDD:214723	5/99 (5%)
		MBT	275..371	CDD:214723	2/95 (2%)
		MBT	383..475	CDD:214723	26/91 (29%)
		SLED	528..643	CDD:371916	31/123 (25%)
		SAM_Scm-like-4MBT1,2	893..975	CDD:188980	27/75 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810