DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and L3mbtl2

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_008763933.1	Gene:	L3mbtl2 / 300320	RGDID:	1308569	Length:	728	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	143/701 - (20%)
Similarity:	207/701 - (29%)	Gaps:	313/701 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GGRDS----STSSGSNSAAPGASTNATSSASASASSTSTSASPGSTTSPASTQRQRGRPAKRATC 63
            ||.||    ::|:||.|::....::...:....|....|  ||....|.|:.:...|..::.|.|
  Rat    28 GGYDSFRSYNSSAGSESSSYLEESSEAENEDREAGELPT--SPLHLFSSANNRALDGSGSEPAVC 90

  Fly    64 TWCGEGKLPLQYVLPTQ----TGKKEFCSETCIAEFRKAYSKGACTQCDNVIRDGAPNKEFCSIM 124
            ..||        ::.|:    :..|.|||.:|    .::||.               |.:..||:
  Rat    91 EMCG--------IVGTREAFFSKTKRFCSVSC----SRSYSS---------------NSKKASIL 128

  Fly   125 C--MNKHQKKNCSTRHSGG---------SASGKGLAESERKLLASGAPAPTGPFQYESFHVFDWD 178
            .  ..|...|.....|...         .|.|.|       .||.|  .|||  |......|||.
  Rat   129 ARLQGKPPTKKAKVLHKAAWSAKIGAFLHAQGTG-------QLADG--TPTG--QDALVLGFDWG 182

  Fly   179 AYLEETGSEAAPAKCFKQA---------------------------------------------- 197
            .:|::...:|||..|||..
  Rat   183 KFLKDHSYKAAPVGCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIATVIQAAGYRVLLRY 247

  Fly   198 ---QNPPNNDF-------------------KI--------------------------------- 207
               :|..::||                   ||
  Rat   248 EGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKSYLMKRLVGSRTLPADFH 312

  Fly   208 -------------GMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHA 259
                         ||:||.:|...|:.|.:|.|..|:|.||||..:..||.:|||..:.|..||.
  Rat   313 IKMVESMKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHP 377

  Fly   260 IG--------------------------------------------------------------- 261
            :|
  Rat   378 VGWSRRVGHGIKMSERRCDMSHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNL 442

  Fly   262 ----------------------------------------------HCEKNGGMLQPPLGFRMNA 280
                                                          .|:||...|.||.|:....
  Rat   443 GNICVATICKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQP 507

  Fly   281 SSWPGYLCKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIH 345
            ..|..||.|..:.|  ||..:|..:.|   .:.||||.||||||...|:|||.|||..:....:.
  Rat   508 FDWESYLEKTKSKA--APARLFNMDCP---NHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLS 567

  Fly   346 VTFDGWRGAFDYWCNYRSRDIFPAGWCARSCHPMQPP--------------GHKSRMDSSSSKQR 396
            :.||||...:|.|.:..|.||:|.|||..:.:.:|||              ..|.:......::|
  Rat   568 IHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAEPNTPQKGKDATKKKKKQFGKKRKR 632

  Fly   397 CPRPRYTVVAES----------EAMVPASPATAHFHP--NCKGGPFINNSK 435
            .|..:...:.:|          ||:..:.|.....||  .|...|.:::.|
  Rat   633 IPSAKTRPLRQSSKKPLLEDNLEALGVSEPVPDDSHPVHCCLSPPRVSSKK 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998	11/43 (26%)
		MBT	178..273	CDD:214723	40/317 (13%)
		MBT	<312..382	CDD:214723	31/69 (45%)
		DUF3588	418..524	CDD:288954	5/20 (25%)
		SAM_Scm	800..870	CDD:188977
		SAM	806..867	CDD:197735
L3mbtl2	XP_008763933.1	MBT	183..283	CDD:214723	12/99 (12%)
		MBT	294..390	CDD:214723	24/95 (25%)
		MBT	433..504	CDD:280910	7/70 (10%)
		MBT	511..604	CDD:214723	39/97 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810