Protein Alignment Scm and SCML4

DIOPT Version :10

• Sequence 1: NP_731385.1
• Gene: Scm / 41168
• FlyBaseID: FBgn0003334
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: XP_047274551.1
• Gene: SCML4 / 256380
• HGNCID: 21397
• Length: 467
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 126/578 - (21%)
• Similarity: 211/578 - (36%)
• Gaps: 197/578 - (34%)

  Fly   309 PEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWRGAFDYWCNYRSRDIFPAGWCA 373
            ||.:|.::.|      .:||.:       .::.||:       .|:.|......|.: :|
Human    64 PENSLDRLRQ------AENPPI-------PLERDQV-------SGSHDSLSPLTSAE-YP----- 102

  Fly   374 RSCHPMQPPG--HKSRMDSSSSKQRCPRPRYTVVAESEAMVPASPATA----HFHPNCKGGPFIN 432
            |:...:.|.|  |..::...:...|.|:.  .:..:|:.: |::|...    :.:.....||::.
Human   103 RARPQLHPSGRSHGPQLGGPTGSHRFPKD--PIRPQSDPL-PSNPVRVAVCLYINKQANAGPYLE 164

  Fly   433 NSKLPCMVT--GPTYQTLAKLCLQEVLAASTDTQQLSKLLFAL-----EGDVHIVTAA--GKNFT 488
            ..|:..:..  ||...:..   ||:.:.|..|.....||:|:|     .|::..|:|:  ||...
Human   165 RKKVQQLPEHFGPERPSAV---LQQAVQACIDCAHQQKLVFSLVKQGYGGEMVSVSASFDGKQHL 226

  Fly   489 VKIPSPMRMKDDESLAQFIETLCTTCRA--CANLISLVHETEECKKCANSRKRQLTQSATPPSSP 551
            ..:|..      .|:...:..|...||:  |.:|.|  |:... :.|:.|.|.|
Human   227 RSLPVV------NSIGYVLRFLAKLCRSLLCDDLFS--HQPFP-RGCSASEKVQ----------- 271

  Fly   552 VLADKRNRQSNSATTSPSEKIIKQELAVKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASK 616
               :|...:..|..|..:|:.:...:.:
Human   272 ---EKEEGRMESVKTVTTEEYLVNPVGM------------------------------------- 296

  Fly   617 SSNKVVIKSEPNGANAQTSSTTQALRKVRFQHHANTNTNSSATNGNQDTSQTTHVSTSHCSSSST 681
                       |..:..||::|       |.|..:.:.:||.                :|...:
Human   297 -----------NRYSVDTSAST-------FNHRGSLHPSSSL----------------YCKRQN- 326

  Fly   682 SSSTSLAGGSANTSTIGKYLAPLVAEVHPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQ 746
            |..:.|.||.|.|:. |...:|: :...|....::|             .||.|...:|...|.:
Human   327 SGDSHLGGGPAATAG-GPRTSPM-SSGGPSAPGLRP-------------PASSPKRNTTSLEGNR 376

  Fly   747 SASSTALAAGGVTAAKAATAPAGAAATAGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEV 811
            .||                           |||..|  .....|.|        ..|..||:|:|
Human   377 CAS---------------------------SPSQDA--QDARRPRS--------RNPSAWTVEDV 404

  Fly   812 IQYIESND-NSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            :.:::..| .:|..|.:|||||||||.|||||.|:|:|||:|||||||||:|..::|:
Human   405 VWFVKDADPQALGPHVELFRKHEIDGNALLLLKSDMVMKYLGLKLGPALKLCYHIDKL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_731385.1	zf-FCS	58..95	CDD:428958
		MBT_dScm_rpt1	196..294	CDD:439097
		MBT_dScm_rpt2	312..383	CDD:439100	12/70 (17%)
		SLED	418..522	CDD:463469	25/118 (21%)
		SAM_Scm	800..870	CDD:188977	38/70 (54%)
SCML4	XP_047274551.1	RBR	1..53	CDD:465382
		SLED	149..258	CDD:463469	26/119 (22%)
		SAM_Scm	393..464	CDD:188977	39/78 (50%)