DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and L3mbtl1

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_011237842.1	Gene:	L3mbtl1 / 241764	MGIID:	2676663	Length:	848	Species:	Mus musculus

Alignment Length:	906	Identity:	201/906 - (22%)
Similarity:	290/906 - (32%)	Gaps:	323/906 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 STSSGSNS----------AAP----GASTNATSSASASASSTSTSASPGSTTSPASTQRQRGRPA 58
            ||.:|:||          :||    |........|..:........||        .||..|..|
Mouse    90 STGTGTNSTVRLLDWTGVSAPLPGSGMRFRINEYAPLNMIGVERPRSP--------EQRHEGGMA 146

  Fly    59 KR---------------------------ATCTWCGEGKLPLQYVLPTQTGKKEFCS--ETCIAE 94
            :|                           ..|..||          |.|:...:..|  :.|...
Mouse   147 RRDAGIQHPDVHQDRQDITSLEPPVDASSCKCQACG----------PQQSSGLDVGSSGDRCSQP 201

  Fly    95 FRK---AYSKGACTQCDNVIRDGAPNKEFCSIMCMNKHQKKNCSTRHSGGSA--SGKGLAESERK 154
            |:|   ......||....:::   |.|:       .||::....:..|...|  .|:| .::||:
Mouse   202 FQKRSVIVENSGCTIASELLK---PMKK-------RKHKEYQSPSEESEPEAVKQGEG-KDAERE 255

  Fly   155 LLASGAPAPTGP----------FQYESFHVFDWDAYLEETGSEAAPAKCFK--QAQNPPNNDFKI 207
                  |.|:.|          ...|....:.|::||||..:..||...|:  ||.....|.||:
Mouse   256 ------PTPSTPENEEWSRSQLVSSEKKDGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKL 314

  Fly   208 GMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQP 272
            |||||.:||::.:...|.||..|.|.||||..||....:|||...:|.:||..|..||.|..||.
Mouse   315 GMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQL 379

  Fly   273 PLGFRMNASSWPGYLCKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVD 337
            |.|::....||..||..  ..|..||:.:|..:........|:||.||||||:.||.|:|.|:|.
Mouse   380 PKGYKEEEFSWSQYLRS--TKAQAAPKHLFVSQSHSTPPVGFQVGMKLEAVDRMNPSLVCVASVT 442

  Fly   338 AIKDDQIHVTFDGWRGAFDYWCNYRSRDIFPAGWCARSCHPMQPPGHKSRMDSSSSKQRCPRP-- 400
            .:.|.:..|.||.|...:||||:..|..|.|.|||.:...|:.||            |..|.|
Mouse   443 DVVDSRFLVHFDDWGDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP------------QDYPDPDS 495

  Fly   401 ----RYTVVAESEAMVPASPATAHFHPN--CKGGP---FINNSKL-------PCMVTGPTYQTLA 449
                :|.....:.|:           ||  .|..|   |:.|.||       |.::.
Mouse   496 FCWEKYLEETGTSAV-----------PNWAFKVRPPHSFLVNMKLEAVDRRNPALIR-------- 541

  Fly   450 KLCLQEVLAASTDTQQLSKLLFALEGDVHIVTAAGKNFTVKIPSPMRMKDDESLAQFIETLCTTC 514
                    .||.:..:..::....:|..|     ..:|.:....|.
Mouse   542 --------VASVEDVEDHRIKLHFDGWSH-----NYDFWIDADHPD------------------- 574

  Fly   515 RACANLISLVHETEECKKCANSRKRQLTQSATPPSSPVLADKRNRQSNSATTSPSEKIIKQELAV 579
                     :|....|.|..:            |..|.|   |.|:|:|.
Mouse   575 ---------IHPAGWCSKTGH------------PLEPPL---RPRESSSV--------------- 600

  Fly   580 KSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASKSSNKVVIKSEPNGANAQTSSTTQALRKV 644
             ||          .|..|.|.::..|:                          :||       |.
Mouse   601 -SP----------GGCPPLSHRSPPHT--------------------------KTS-------KY 621

  Fly   645 RFQHHANTNTNSSATNGNQDTSQTTHVSTSHCSSSSTS--------SSTSLAGGSANTSTIGKYL 701
            .| ||....|.....:|:.....|.|...|.|..:..:        |.:..|....|.|.    |
Mouse   622 NF-HHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAEKNQSRLKAELSDSETAARKKNPSN----L 681

  Fly   702 APLVAEVH-------PEQANVKPSNSYYKSPTTLSSS---ASLPTSVSTPFTGCQSASSTALAAG 756
            :|.....|       |:...:...:.....|:.:..|   ::|||....|.:.|.......|.
Mouse   682 SPRKKPRHQGRIGRPPKYRKIPEEDLQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHCKLLP-- 744

  Fly   757 GVTAAKAATAPAGAAATAGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEVIQYIES 817
            ||....|:|..                                     .||||||..::::
Mouse   745 GVAGISASTVS-------------------------------------KWTIEEVFGFVQT 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998	10/68 (15%)
		MBT	178..273	CDD:214723	42/96 (44%)
		MBT	<312..382	CDD:214723	31/69 (45%)
		DUF3588	418..524	CDD:288954	15/117 (13%)
		SAM_Scm	800..870	CDD:188977	6/18 (33%)
		SAM	806..867	CDD:197735	6/12 (50%)
L3mbtl1	XP_011237842.1	MBT	283..380	CDD:214723	42/96 (44%)
		MBT	391..487	CDD:214723	37/97 (38%)
		MBT	499..591	CDD:214723	21/163 (13%)
		zf-C2HC	627..655	CDD:366692	6/27 (22%)
		SAM_superfamily	754..>787	CDD:387673	6/52 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810