Protein Alignment Scm and L3mbtl3

DIOPT Version :10

• Sequence 1: NP_731385.1
• Gene: Scm / 41168
• FlyBaseID: FBgn0003334
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: NP_766375.1
• Gene: L3mbtl3 / 237339
• MGIID: 2143628
• Length: 883
• Species: Mus musculus
• Alignment Length: 943
• Identity: 239/943 - (25%)
• Similarity: 354/943 - (37%)
• Gaps: 211/943 - (22%)

  Fly    11 SGSNSAAPGASTNATSSASASASSTSTSAS-----PGSTTSPAST----QRQRGRPAKR------ 60
            |...|.....:|......:|..:.||..:|     |...|||...    ..:.|.|.:.
Mouse    50 SEMESVKKATATTTWMVPTAQDAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGVPFRLKEQSKA 114

  Fly    61 ------ATCTWCGEGKLPLQYVLPTQTGKKEFCSETCIAEFRKAYSKGACTQCDNVIRDGAPNKE 119
                  ..|...|.|...|       :|.| :||:.|.   |.|..|   .|.|.  |||..:.:
Mouse   115 DGLQFCENCCQYGNGDECL-------SGGK-YCSQNCA---RHAKDK---DQKDE--RDGGEDND 163

  Fly   120 FCSIMCMNKHQKK----------------NCSTRHSGGSASGKGLAESERK----LLASGAPAPT 164
            .....|..|.:.|                ....:..|....|...|..:|:    :|..|.| |.
Mouse   164 EEDPKCSRKKKPKLSLKADSKDDGEERDDEMENKQDGRILRGSQRARRKRRGDSAVLKQGLP-PK 227

  Fly   165 GPFQYESFHVFDWDAYLEETGSEAAPAKCFKQAQNPP--NNDFKIGMKLEALDPRNVTSTCIATV 227
            |.      ..:.|.:||||..:.|.|.|.||:.|:.|  .|.||:|||||.:||.:....|:.||
Mouse   228 GK------KTWCWASYLEEEKAVAVPTKLFKEHQSFPYNKNGFKVGMKLEGVDPDHQAMYCVLTV 286

  Fly   228 VGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQPPLGFRMNASSWPGYL--CKI 290
            ..|.|.|::|..||.....|||...|:.:||.:|.|||.|..|:||.|::....:|..||  ||
Mouse   287 AEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLRPPKGYKEEEFNWQSYLKTCK- 350

  Fly   291 LNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWRGAF 355
               |..||:.:|:.:......:.|:||.||||.|||:|.:||.|||..:.|::..|.||.|..::
Mouse   351 ---AQAAPKSLFENQNITVIPSGFRVGMKLEAADKKSPSVICVATVTDMVDNRFLVHFDNWDESY 412

  Fly   356 DYWCNYRSRDIFPAGWCARSCHPM-QPPGHKSRMDSSSSKQRCPRPRYTVVAESEAMVPASPATA 419
            ||||...|..|.|.|||......: .|||:......|..|          ..|....:|| ||.|
Mouse   413 DYWCESNSPHIHPVGWCKEHRRTLITPPGYSHVKHFSWDK----------YLEETNSLPA-PARA 466

  Fly   420 HFHPNCKGGP---FINNSKLPCM-VTGPTYQTLAKLCLQEVLAASTDTQQLSKLLF--------- 471
            .     |..|   |....||..: ...|.:..:|.:       |.||..:: |:.|
Mouse   467 F-----KVKPPHGFQKKMKLEAVDKRNPLFIRVATV-------ADTDDHRI-KVHFDGWSSCYDY 518

  Fly   472 ---ALEGDVHIVTAAGK-NFTVKIP-SPMRMKDDESLAQFIETLCTT--CRACANL-ISLVHETE 528
               |...|:|.|....| ...::.| ||..:.:......     |.|  ||...:. .|....|:
Mouse   519 WIDADSPDIHPVGWCSKTGHPLQAPLSPAELMEPSETGG-----CPTLGCRGVGHFKKSRYLGTQ 578

  Fly   529 ECKKCAN-----SRKR----QLTQSATPPSSPVLADKRNRQSNSATTSPSEKIIKQELAVKSPVE 584
            ....|..     |::|    :|:...:||::|.....:...:..:::||               |
Mouse   579 SGANCPYSEINLSKERIFPDRLSGDTSPPTTPSFPRSKRMDTRESSSSP---------------E 628

  Fly   585 SKSKTSTNNGKEPASQQNSNHSLNNNNNSASKSSNKVVIKSEPNGANAQTSSTTQALRKVRFQHH 649
            ::.| ..||.||.:.::        ..|....|:...|::.||. .:.|.|...|.:::|:   |
Mouse   629 TREK-HANNFKEDSEKK--------KENEVKTSAEAKVVREEPT-PSVQQSQPPQQVQQVQ---H 680

  Fly   650 ANTNTNSSATNGNQDTSQTTHVSTSHCSSSSTSSSTSLAGGSANTSTIGKYLAPLVAEVHPEQAN 714
            |.....:......|...|......:..:..:.....                ||.|     :||.
Mouse   681 AQPPQQAQKAPQAQQAQQAQQAQQAPQAPQTPQPQQ----------------APQV-----QQAQ 724

  Fly   715 VKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQSASSTALAAGGVTAAKAATA------------P 767
            ..|.....:.|.........| .|..| ...|.|..|...|.....|:..:|            |
Mouse   725 QAPQAQQAQQPQQAQQPQQAP-PVQQP-QQVQQAQPTQQQAQTQQQAQRRSAVFLSFKPPIPCLP 787

  Fly   768 AGAAATAGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEVIQYIESNDNSLAVHGDLFRKH 832
            ......:...|:...|      |.|.::.         |:.:||.::|:|.. ....||.:|:..
Mouse   788 LRWEQQSKLLPTVAGI------PASRVSK---------WSTDEVSEFIQSLP-GCEEHGKVFKDE 836

  Fly   833 EIDGKALLLLNSEMMMKYMGLKLGPALKICNLV 865
            :|||:|.||:....::|.|.:||||||||.|.:
Mouse   837 QIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSI 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_731385.1	zf-FCS	58..95	CDD:428958	9/48 (19%)
		MBT_dScm_rpt1	196..294	CDD:439097	41/101 (41%)
		MBT_dScm_rpt2	312..383	CDD:439100	32/71 (45%)
		SLED	418..522	CDD:463469	25/124 (20%)
		SAM_Scm	800..870	CDD:188977	25/66 (38%)
L3mbtl3	NP_766375.1	Interaction with RBPJ. Required for transcription repressor activity on Notch target genes. /evidence=ECO:0000250|UniProtKB:Q96JM7	1..64		3/13 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..223		15/81 (19%)
		MBT 1	232..332		43/99 (43%)
		MBT_L3MBTL3_rpt1	259..359	CDD:439122	42/103 (41%)
		MBT 2	340..439		40/102 (39%)
		MBT_L3MBTL3_rpt2	366..458	CDD:439125	37/101 (37%)
		MBT 3	448..543		25/118 (21%)
		MBT_L3MBTL3_rpt3	467..544	CDD:439128	17/89 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..768		39/223 (17%)
		SAM_Scm-like-3MBT3,4	808..873	CDD:188981	25/72 (35%)