DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and SCMH1

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_001381240.1	Gene:	SCMH1 / 22955	HGNCID:	19003	Length:	670	Species:	Homo sapiens

Alignment Length:	748	Identity:	260/748 - (34%)
Similarity:	335/748 - (44%)	Gaps:	174/748 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 FDWDAYLEETGSEAAPAKCFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRL 239
            |.||.||:||.|..||..||||:..||:|:|||.|||||.||||.||||||||||:.|:||||||
Human    38 FTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRL 102

  Fly   240 DGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQPPLGFRMNASSWPGYLCKILNNAMVAPEEIFQP 304
            ||||::|||||||||.||..||:|||||||||||||||:||||||.:|.|.||.|.:||..||..
Human   103 DGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHK 167

  Fly   305 EPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWRGAFDYWCNYRSRDIFPA 369
            |||.|..|.||:|.||||||:|||..||.||:..::..::.||||||||||||||.:.||||||.
Human   168 EPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPV 232

  Fly   370 GWCARSCHPMQPPGHKSRMDSSSSKQRCPRPRYTVVAESEAMVPASPATAHFHPNCKGGPFINNS 434
            |||:.:...:||||.|..:..:      |.|...|..|..::..::.......|..:|
Human   233 GWCSLTGDNLQPPGTKVVIPKN------PYPASDVNTEKPSIHSSTKTVLEHQPGQRG------- 284

  Fly   435 KLPCMVTGPTYQTLAKLCLQEVLAASTDTQQLSKLLFALEGDVHIVTAAGKNF-TVKIPSPMRMK 498
            :.|....|.|.:||..                           |.::|..|.. .:|.|.....|
Human   285 RKPGKKRGRTPKTLIS---------------------------HPISAPSKTAEPLKFPKKRGPK 322

  Fly   499 DDESLAQFIETLCTTCRACANLISLVHETEECKKCANSRKRQLTQSATPPSSPVLADKRNRQSNS 563
                                               ..|:::..|....||:||          .:
Human   323 -----------------------------------PGSKRKPRTLLNPPPASP----------TT 342

  Fly   564 ATTSPSEKIIKQELAVKSPVESKSKT-----STNNGKEPASQQNSNHSLNNNNNSASKS------ 617
            :|..|....:.|:.|.......::.|     :.|....|...:.....|.::...|..|
Human   343 STPEPDTSTVPQDAATIPSSAMQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASVVLQQA 407

  Fly   618 ---------SNKVVIKSEPNGANAQ-----------------TSSTTQALRKVRFQHHANTNTNS 656
                     ..|.|......|...:                 .:|.|..||.:....|   |..|
Human   408 VQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAVNSITYVLRFLEKLCH---NLRS 469

  Fly   657 SATNGNQDTSQT----THVSTSHCSSSSTSSSTSLAGGSANTSTIGKYLAPLVAEVHPEQANVKP 717
            ....|||..:||    |.:..||.........|.:.|.|     :.:.|.|     |.:..:
Human   470 DNLFGNQPFTQTHLSLTAIEYSHSHDRYLPGETFVLGNS-----LARSLEP-----HSDSMD--- 521

  Fly   718 SNSYYKSPTTLSSSASLPTS-VSTP------FTGCQSASSTA-----LAAGGVTAAKAATAPAGA 770
                         |||.||: |||.      .:.|....|||     |.:.||...........:
Human   522 -------------SASNPTNLVSTSQRHRPLLSSCGLPPSTASAVRRLCSRGVLKGSNERRDMES 573

  Fly   771 AATAGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEVIQYIESNDNSLAVHGDLFRKHEID 835
            ......||.......  |...|.|:.    ..|..||:|:|:|::...|..|..|.|||||||||
Human   574 FWKLNRSPGSDRYLE--SRDASRLSG----RDPSSWTVEDVMQFVREADPQLGPHADLFRKHEID 632

  Fly   836 GKALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            |||||||.|:|||||||||||||||:...::::
Human   633 GKALLLLRSDMMMKYMGLKLGPALKLSYHIDRL 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	70/94 (74%)
		MBT	<312..382	CDD:214723	41/69 (59%)
		DUF3588	418..524	CDD:288954	13/106 (12%)
		SAM_Scm	800..870	CDD:188977	41/69 (59%)
		SAM	806..867	CDD:197735	40/60 (67%)
SCMH1	NP_001381240.1	MBT	41..136	CDD:214723	70/94 (74%)
		MBT	147..245	CDD:214723	55/97 (57%)
		PHA03247	<243..367	CDD:223021	32/208 (15%)
		RBR	281..334	CDD:407329	14/121 (12%)
		SLED	368..476	CDD:403384	17/110 (15%)
		SAM_Scm	597..667	CDD:188977	41/73 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5656
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1912
Isobase	1	0.950	-	0	Normalized mean entropy	S6707
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123551at33208
OrthoFinder	1	1.000	-	-		FOG0005433
OrthoInspector	1	1.000	-	-		otm40902
orthoMCL	1	0.900	-	-		OOG6_105988
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910