Protein Alignment Scm and PHC2

DIOPT Version :10

• Sequence 1: NP_731385.1
• Gene: Scm / 41168
• FlyBaseID: FBgn0003334
• Length: 877
• Species: Drosophila melanogaster
• Sequence 2: NP_001372041.1
• Gene: PHC2 / 1912
• HGNCID: 3183
• Length: 881
• Species: Homo sapiens
• Alignment Length: 965
• Identity: 202/965 - (20%)
• Similarity: 307/965 - (31%)
• Gaps: 319/965 - (33%)

  Fly     5 RDSSTSSGSNSA-APGASTNATSSASASA--------SSTSTSASP--------GSTTSPAST-- 50
            |..|||..:.|| ||..|::...:||.:|        |..|.:||.        |:|:|||.|
Human   118 RQGSTSGSNVSAQAPAQSSSINLAASPAAAQLLNRAQSVNSAAASGIAQQAVLLGNTSSPALTAS 182

  Fly    51 ------QRQRGRPAKRATCTWCGEGKLPLQYVL---PTQTGKKEFCSETCIAEFRKAYSKGACTQ 106
                  :.|..:|...........|.:||...|   ||.|          :|..:.....|
Human   183 QAQMYLRAQMAQPGNLVQVARSLGGTVPLSPQLIFTPTAT----------VATVQPELGTG---- 233

  Fly   107 CDNVIRDGAPNKEFCSIMCMNKHQKKNCSTRHSGGSASGKGLAESERKLLASGAPAPTGPFQYES 171
              :..|...|            .|.:|.:.|.....|:            |:..|.||.|...
Human   234 --SPARPPTP------------AQVQNLTLRTQQTPAA------------AASGPTPTQPVLP-- 270

  Fly   172 FHVFDWDAYLEET--GSE--AAPAKCFKQAQNPPNNDFKIGMKLEALDPRNVTSTCIATVVGVLG 232
                  ...|:.|  ||:  ..||:....||..|.. .|.|:....::|.. .....::|.|.:.
Human   271 ------SLALKPTPGGSQPLPTPAQSRNTAQASPAG-AKPGIADSVMEPHK-KGDGNSSVPGSME 327

  Fly   233 SRLRLRLDGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQPPLGFRMNASSWPGYLCKILNNAMVA 297
            .|..|.           |.|.:...|              ||.....|...|..|....::..:.
Human   328 GRAGLS-----------RTVPAVAAH--------------PLIAPAYAQLQPHQLLPQPSSKHLQ 367

  Fly   298 PEEIFQPEP------PEPEENLFKVGQKLEAVDKKNPQLICCATVDAIK-DDQIH------VTFD 349
            |:.:.|.:|      |.|:::    ...|:|  :.:|||...:...|:: ..:.|      ||
Human   368 PQFVIQQQPQPQQQQPPPQQS----RPVLQA--EPHPQLASVSPSVALQPSSEAHAMPLGPVT-- 424

  Fly   350 GWRGAFDYWC---NYRSRDIFPAGWCARSCHPMQPP-----GHKSRMDSSSSKQRCPRPRY---- 402
               .|....|   |...    |.|  ::.|||..|.     ||...:..:      |:.|:
Human   425 ---PALPLQCPTANLHK----PGG--SQQCHPPTPDTGPQNGHPEGVPHT------PQRRFQHTS 474

  Fly   403 TVVAESEAMVPASPATAHFHPNCKGGPFINNSKLPCMVTGPTYQTLAKLCLQEVLAASTDTQQLS 467
            .|:.:   :.||||......|:...........:|...:||:....|
Human   475 AVILQ---LQPASPVPQQCVPDDWKEVAPGEKSVPETRSGPSPHQQA------------------ 518

  Fly   468 KLLFALEGDVHIVTAAGKNFTVKIPSPMRMKDDESLAQFIETLCTTCRACANLISLVHETEECKK 532
             ::.|:.|.:.:.|:....     |||                             .|||.:
Human   519 -IVTAMPGGLPVPTSPNIQ-----PSP-----------------------------AHETGQ--- 545

  Fly   533 CANSRKRQLTQSATPPSSP-VLADKRNRQSNSATTSPS-------EKIIK-------------QE 576
                   .:..:.|..||| :.:...|..|:.|.|:|.       :.|:|             ||
Human   546 -------GIVHALTDLSSPGMTSGNGNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEGFVIQE 603

  Fly   577 LAVKSPVESKS------KTSTNNGKEPASQQNSNHSLNNNNNSASKSSNKVVIKSEPNGANAQTS 635
            .|...||...|      |.....|..|......:|:...:    |:.....:.:|:..||..:..
Human   604 GAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQDHTTTTD----SEMEEPYLQESKEEGAPLKLK 664

  Fly   636 STTQALRKVRFQHHANTNTN--SSATNGNQDTSQTTHVSTSHCSSSSTSSSTSLAGGSANTSTIG 698
              .:...:|.|.:....:..  |.|.....:...|..|...|    |..|....||
Human   665 --CELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFH----SDRSKLQKAG--------- 714

  Fly   699 KYLAPLVAEVHPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQSASSTALAAGGVTAAKA 763
                   |..|..:.               :|.||||     |.|.......|......||||..
Human   715 -------AATHNRRR---------------ASKASLP-----PLTKDTKKQPTGTVPLSVTAALQ 752

  Fly   764 ATAPAGAAATAGASPSYTAITSPVSTPTSA-----------LANSHLR-----------SQPIDW 806
            .|.....::....:.||....||:|..:|.           |.:.|:|           |:|..|
Human   753 LTHSQEDSSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELPDMHMRDLVGMGHHFLPSEPTKW 817

  Fly   807 TIEEVIQYIESNDNSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLKLGPALKI 861
            .:|:|.::|.|......: .:.||..||||:|||||..:.:|..|.:||||||||
Human   818 NVEDVYEFIRSLPGCQEI-AEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKI 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_731385.1	zf-FCS	58..95	CDD:428958	8/39 (21%)
		MBT_dScm_rpt1	196..294	CDD:439097	18/97 (19%)
		MBT_dScm_rpt2	312..383	CDD:439100	18/85 (21%)
		SLED	418..522	CDD:463469	11/103 (11%)
		SAM_Scm	800..870	CDD:188977	29/73 (40%)
PHC2	NP_001372041.1	PHA03247	<116..571	CDD:223021	120/616 (19%)
		PHC2_SAM_assoc	693..812	CDD:465202	31/158 (20%)
		SAM_Ph1,2,3	812..880	CDD:188976	28/61 (46%)