DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and SCML2

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	NP_006080.1	Gene:	SCML2 / 10389	HGNCID:	10581	Length:	700	Species:	Homo sapiens

Alignment Length:	811	Identity:	269/811 - (33%)
Similarity:	377/811 - (46%)	Gaps:	223/811 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 ESERKLLASGAPAPTGPFQYESFHVFDWDAYLEETGSEAAPAKCFKQAQNPPNNDFKIGMKLEAL 214
            |::.|...|.    |...|.:.||   |:.||:||||.:||::||:|:|.||.||||:||||||.
Human    15 ENQEKTPQSS----TSSVQRDDFH---WEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEAR 72

  Fly   215 DPRNVTSTCIATVVGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHAIGHCEKNGGMLQPPLGFRMN 279
            ||||.||.|||||:|:.|:||||||||||::|||||||||.:|..:|.|||.|.:||||||::||
Human    73 DPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMN 137

  Fly   280 ASSWPGYLCKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQI 344
            .||||.:|.|.||.:.:|...:|:.|||:|..|.||||.||||:|||||.|||.||:..:|.|::
Human   138 TSSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEV 202

  Fly   345 HVTFDGWRGAFDYWCNYRSRDIFPAGWCARSCHPMQPPG-------HKSRMDSS---SSKQRCPR 399
            |:|||||.|||||||.|.||||||||||..:...:||||       :.::.:||   :|:.....
Human   203 HITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTESSPSEASQHSMQS 267

  Fly   400 PRYTV-------VAESEAMVPASP--------ATAHFHPNCKGGPFINNSK----LP--C----- 438
            |:.|.       |..|..:.|..|        :..:..|. |.||  |:.|    ||  |
Human   268 PQKTTLILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPR-KKGP--NSGKKEKPLPVICSTSAA 329

  Fly   439 ---------------MVTGPTYQTLAKLC---------------------------------LQE 455
                           :.:||....::.:|                                 |:.
Human   330 SLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRR 394

  Fly   456 VLAASTDTQQLSKLLFA-LEGD---VHIVTAA--GKNFTVKIPSPMRMKDDESLA-QFIETLCTT 513
            ::.|..|....:|.:|. |:.|   ..::||:  |:..::::| |:   :..|.| :|:|..|.:
Human   395 IVQACVDCALETKTVFGYLKPDNRGGEVITASFDGETHSIQLP-PV---NSASFALRFLENFCHS 455

  Fly   514 CRACANLISLVHETEECKKCANSRKRQLTQSATPPSSPVLADKRNRQSNSATTSPSEKIIKQELA 578
            .: |.||:|....:.......:|.:....|||.       .|...|||..  .||.:.:  ..:.
Human   456 LQ-CDNLLSSQPFSSSRGHTHSSAEHDKNQSAK-------EDVTERQSTK--RSPQQTV--PYVV 508

  Fly   579 VKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASKSSNKVVIKSEPNGANAQTSSTTQALRK 643
            ..||...|:|...:.| ||.....|......|.:..||||:.       |..|    ....|.|.
Human   509 PLSPKLPKTKEYASEG-EPLFAGGSAIPKEENLSEDSKSSSL-------NSGN----YLNPACRN 561

  Fly   644 VRFQHHANTNTNSSATNGNQDTSQTTHVSTSHCSSSSTSSSTSLAGGSANTSTIGKYLAPLVAEV 708
            ..:.|          |:.:||.|::...:||                           :|||.::
Human   562 PMYIH----------TSVSQDFSRSVPGTTS---------------------------SPLVGDI 589

  Fly   709 HPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQSASSTALAAGGVTAAKAATAPAGAAAT 773
            .|     |.|....|......|.|
Human   590 SP-----KSSPHEVKFQMQRKSEA----------------------------------------- 608

  Fly   774 AGASPSYTAITSPVSTPTSALANSHLRSQPIDWTIEEVIQYIESNDNSLA-VHGDLFRKHEIDGK 837
                |||.|:..|      ::........|..|:::||||:::..|..:: ...||||:||||||
Human   609 ----PSYIAVPDP------SVLKQGFSKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGK 663

  Fly   838 ALLLLNSEMMMKYMGLKLGPALKICNLVNKV 868
            ||.||.|::||||||||||||||:|..:.|:
Human   664 ALFLLKSDVMMKYMGLKLGPALKLCYYIEKL 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998
		MBT	178..273	CDD:214723	64/94 (68%)
		MBT	<312..382	CDD:214723	46/69 (67%)
		DUF3588	418..524	CDD:288954	33/171 (19%)
		SAM_Scm	800..870	CDD:188977	38/70 (54%)
		SAM	806..867	CDD:197735	36/61 (59%)
SCML2	NP_006080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		5/21 (24%)
		MBT 1	33..131		67/100 (67%)
		MBT	36..131	CDD:214723	64/94 (68%)
		MBT 2	139..240		60/100 (60%)
		MBT	142..240	CDD:214723	57/97 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..320		15/69 (22%)
		DUF3588	356..465	CDD:288954	22/113 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..550		23/102 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..594		7/50 (14%)
		SAM_Scm	625..696	CDD:188977	38/70 (54%)
		SAM	628..696	CDD:197735	38/67 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6588
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1912
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123551at33208
OrthoFinder	1	1.000	-	-		FOG0005433
OrthoInspector	1	1.000	-	-		otm40902
orthoMCL	1	0.900	-	-		OOG6_105988
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.920