DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scm and l3mbtl3

DIOPT Version :9

Sequence 1:	NP_001247006.1	Gene:	Scm / 41168	FlyBaseID:	FBgn0003334	Length:	877	Species:	Drosophila melanogaster
Sequence 2:	XP_004911641.2	Gene:	l3mbtl3 / 100496330	XenbaseID:	XB-GENE-1219135	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	893	Identity:	206/893 - (23%)
Similarity:	304/893 - (34%)	Gaps:	251/893 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ATSSASASASSTSTSASPGSTTSPASTQRQRGRPAKRATCTWCGEGKLPLQYVLPTQTGKKEFCS 88
            ||...|..|..|.|..|..|..|.......:....::.|.    |..||.  |.|.:
Frog    77 ATLPQSGQAFGTDTHTSSVSIFSQVIKIEDKDPEMEKKTT----EESLPT--VQPAE-------- 127

  Fly    89 ETCIAEFRKAYSKGACTQCDN-----------VIRDGAPNKEFCSIMCMNK-HQKKNCSTRHSGG 141
            |...|......:.|:.|..:|           ::.|....::......||. |.|...:.:....
Frog   128 EQPTAPVPPTVASGSSTYIENERPQRLRRKRKLLMDSGDEEDLLDDEEMNHWHDKIKANLKSRKT 192

  Fly   142 SASGKGLAESERKLLASGAPAPTGPFQYESFHVFDWDAYLEETGSEAAPAKCFKQAQNPP--NND 204
            |...|.....::||                   ::|.:||||....|.|.||||:.|:.|  .|:
Frog   193 SKQTKTAPPPKKKL-------------------WNWVSYLEEEKMPAVPLKCFKEHQSFPQSRNN 238

  Fly   205 FKIGMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHAIGHCEKNGGM 269
            |:.|||||.:||.:.:..|:.||..|.|.|:||..||.....|||...||.:||.:|.||:.|..
Frog   239 FRGGMKLEGIDPEHPSLYCVLTVAEVQGYRMRLHFDGYPDCYDFWVNADSVDIHPVGWCERTGHK 303

  Fly   270 LQPPLGFRMNASSWPGYL--CKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLIC 332
            |.||.|::....||..||  ||    |..||:.:|:........:.|:...||||||:|||.|:|
Frog   304 LLPPKGYKDGEFSWAAYLKHCK----AQGAPKTLFKSYNTPVTPSGFRAAMKLEAVDRKNPSLLC 364

  Fly   333 CATVDAIKDDQIHVTFDGWRGAFDYWCNYRSRDIFPAGWCARSCHPMQPPGHKSRMDSSSSKQRC 397
            .||:..|.::::.:.||.|..::||||:..|..|.|.|:|..|...:.||       ......:|
Frog   365 VATISDIVENRLLIHFDSWDHSYDYWCDASSPYIRPVGYCQESAIALTPP-------PEYKDPKC 422

  Fly   398 PRPRYTVVAESEAM-VPASPATAHFHPNCKGGPFINNSKLPCMVTGPTYQTLAKLCLQE------ 455
                :|..|..|.. ..|:||.| |.|....|                ||...||...:
Frog   423 ----FTWEAYLEKTGAQAAPARA-FKPRPPHG----------------YQPQMKLEAVDQRNPML 466

  Fly   456 VLAASTDTQQLSKLLFALEG--------------DVHIVTAAGK-NFTVKIPSPMRMKDDESLAQ 505
            :...||..:..:::....:|              |:|.|....| ...:::|     .....:|.
Frog   467 IRVCSTVQKDDNRIKLHFDGWSSLYDFWVDVDSPDIHPVGWCAKTGHALQLP-----PGASDMAA 526

  Fly   506 FIETLCTTCRACANLISL------VHETEECKKC----ANSRKRQLTQSATPPSSPVLADKRNRQ 560
            .....|... .|..:..:      .|.|  ...|    .|..:..|.|.......|.......|.
Frog   527 VAGQGCPIA-GCTGIGHVRGSRYGTHYT--AVGCPYSEVNLNRENLLQDRLSGERPSPVQNATRS 588

  Fly   561 SNSATTSPSEKIIKQELAVKSPVESKSKTSTNNGKEPASQQNSNHSLNNNNNSASKSSNKV-VIK 624
            ....|.||:........:.|||:..:.:...:|..|..................|.:..:: :||
Frog   589 RRPGTPSPTTDSSDFPQSRKSPIPVEERWGRSNPWEGTEWLEEETETKPQIKRGSHTYIRLQIIK 653

  Fly   625 SEPNGANAQTSSTTQALRKVRFQHHANTNTNSSATNGNQDTSQTTHVS-TSHCSSSSTSSSTSLA 688
            .|.:|.:.:. |..|||.:..|.           |:.:.|.....|:. ...|
Frog   654 QETDGTDCEV-SLEQALHQSVFM-----------TSLSSDPGHRIHMCWEQQC------------ 694

  Fly   689 GGSANTSTIGKYLAPLVAEVHPEQANVKPSNSYYKSPTTLSSSASLPTSVSTPFTGCQSASSTAL 753
                       ||.|.|:
Frog   695 -----------YLLPEVS----------------------------------------------- 701

  Fly   754 AAGGVTAAKAATAPAGAAATAGASPSYTAITSPVSTPTSALANSHLRSQPI-DWTIEEVIQYIES 817
                                     ||||                   |.: .|:.:||.|::..
Frog   702 -------------------------SYTA-------------------QSVGKWSADEVAQFVHQ 722

  Fly   818 NDNSLAVHGDLFRKHEIDGKALLLLNSEMMMKYMGLKLGPALKICNLV 865
            .. .......:||..:|||:|.|||....::|.:||||||||||.|.:
Frog   723 LP-GCTEQSSVFRDEQIDGEAFLLLTQNDLVKILGLKLGPALKIYNSI 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scm	NP_001247006.1	zf-FCS	55..95	CDD:283998	8/39 (21%)
		MBT	178..273	CDD:214723	43/96 (45%)
		MBT	<312..382	CDD:214723	28/69 (41%)
		DUF3588	418..524	CDD:288954	19/132 (14%)
		SAM_Scm	800..870	CDD:188977	26/67 (39%)
		SAM	806..867	CDD:197735	25/60 (42%)
l3mbtl3	XP_004911641.2	MBT	211..307	CDD:214723	43/95 (45%)
		MBT	319..414	CDD:214723	36/98 (37%)
		MBT	426..518	CDD:214723	20/108 (19%)
		SAM_Scm-like-3MBT3,4	708..773	CDD:188981	25/63 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910