DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SpdS and SPE3

DIOPT Version :9

Sequence 1:	NP_001247005.1	Gene:	SpdS / 41167	FlyBaseID:	FBgn0037723	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_015394.1	Gene:	SPE3 / 856182	SGDID:	S000006273	Length:	293	Species:	Saccharomyces cerevisiae

Alignment Length:	279	Identity:	136/279 - (48%)
Similarity:	193/279 - (69%)	Gaps:	1/279 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NGWFSELQADLWPGQSFSLKVKEVIHKEKSRFQDIQIVETETYGRCLILDGIIQCTARDEFSYQE 70
            :|||.|:...:||||:.:|||::|:|.|||::||:.|.::.|||..|:||.:||.|.||||:|||
Yeast    12 DGWFREISDTMWPGQAMTLKVEKVLHHEKSKYQDVLIFKSTTYGNVLVLDNVIQATERDEFAYQE 76

  Fly    71 MISFLPLCAHPNPKKVLIVGGGDGGVAREVVKHPLVEEVHQVEIDDRVVELSKQYLPAMACGFAN 135
            ||:.|.|.:||||||||::|||||||.||||||..|||....:||:.|:.|||:|||.||..:::
Yeast    77 MIAHLALNSHPNPKKVLVIGGGDGGVLREVVKHDSVEEAWLCDIDEAVIRLSKEYLPEMAASYSH 141

  Fly   136 EKLKLTIGDGFDYMKKHKNEFDVIITDSSDPIGPAVSLFQESYYELMKHALKDDGIVCSQGGSFW 200
            .|:|..|||||.:::.::|.|||||||||||.|||.:|||:.|::|:..||.:.|::.:|..|.|
Yeast   142 PKVKTHIGDGFQFLRDYQNTFDVIITDSSDPEGPAETLFQKEYFQLLNSALTEKGVITTQAESMW 206

  Fly   201 LDLDYIKKTMSGCKEHFAKVAYAVTSVPSYPCGHIGFVMGSLNKNQDFATPKLGKSEIDSIDL-R 264
            :.|..||.....|.|.|....|:..::|:||.|.|||::.|.:|..:...|....|:....:| |
Yeast   207 IHLPIIKDLKKACSEVFPVAEYSFVTIPTYPTGTIGFMVCSKDKTCNVKKPLREISDEKEAELYR 271

  Fly   265 YYSSEVHSAAFALPRWVQK 283
            ||:.::|.|:|.||.|..|
Yeast   272 YYNKKIHEASFVLPTWAAK 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SpdS	NP_001247005.1	AdoMet_MTases	1..283	CDD:302624	135/277 (49%)
SPE3	NP_015394.1	speE	14..287	CDD:188048	133/272 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346453
Domainoid	1	1.000	199	1.000	Domainoid score	I571
eggNOG	1	0.900	-	-		E1_COG0421
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40514
Inparanoid	1	1.050	292	1.000	Inparanoid score	I523
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54216
OrthoFinder	1	1.000	-	-		FOG0002410
OrthoInspector	1	1.000	-	-		otm46944
orthoMCL	1	0.900	-	-		OOG6_100634
Panther	1	1.100	-	-	LDO	PTHR11558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1380
SonicParanoid	1	1.000	-	-		X1601
TreeFam	1	0.960	-	-
	15	14.790