Protein Alignment Calr and CANX

DIOPT Version :10

• Sequence 1: NP_524293.2
• Gene: Calr / 41166
• FlyBaseID: FBgn0005585
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_001350922.1
• Gene: CANX / 821
• HGNCID: 1473
• Length: 646
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 169/529 - (31%)
• Similarity: 240/529 - (45%)
• Gaps: 155/529 - (29%)

  Fly    18 SAEVYLKENFDNENWEDTWIYS------------KHPGK---EFGKFVLTPGTFYNDAEADKGIQ 67
            :.|||..::||...... ||.|            |:.||   |..|....||        |||:.
Human   120 TGEVYFADSFDRGTLSG-WILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPG--------DKGLV 175

  Fly    68 TSQDARFYAASRKFD-GFSNEDKPLVVQFSVKHEQNIDCGGGYVKLF----DCSLDQTDMHGESP 127
            ....|:.:|.|.|.: .|..:.|||:||:.|..:..|:|||.||||.    :.:|||  .|.::|
Human   176 LMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQ--FHDKTP 238

  Fly   128 YEIMFGPDICGPGTKKVHVIFSYKG-------KNHLISKDIRCK---DDVYTHFYTLIVRPDNTY 182
            |.||||||.||. ..|:|.||.:|.       :.|....|...|   .|..||.||||:.|||::
Human   239 YTIMFGPDKCGE-DYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSF 302

  Fly   183 EVLIDNEKVESGNLEDDWDFLAP-----KKIKDPTATKPEDWDDRATIPDPDDKKPEDW------ 236
            |:|:|...|.||||.:|   :.|     ::|:||...||||||:|..||||:..||:||
Human   303 EILVDQSVVNSGNLLND---MTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPA 364

  Fly   237 ---------------DKPEHIPDPDATKPEDWDDEMDGEWEP-------------------PMID 267
                           |:||::|||||.||||||::||||||.                   |:||
Human   365 KIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVID 429

  Fly   268 NPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIFDNVLI 332
            ||.:||:|:|..:|||:|:|.|:..:|.||::..|.:.:.......:|.:||.:.|...|||.:|
Human   430 NPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFII 494

  Fly   333 TDD-------------VELAAKAAA---------------------------------------- 344
            ..|             ::.||..||
Human   495 CADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSG 559

  Fly   345 -------EVKNTQAGEKKMKEAQDEVQRKKD-----EEEAKKASDKDDEDEDDDDEEKDDESKQD 397
                   |.|.|.|.:..:||.::|.:.:||     ||..:|..:|...|.::|......|.:..
Human   560 KKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDR 624

  Fly   398 KDQSEHDEL 406
            |.::|.||:
Human   625 KPKAEEDEI 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Calr	NP_524293.2	Calreticulin	25..332	CDD:459737	140/381 (37%)
CANX	NP_001350922.1	Calreticulin	125..494	CDD:459737	140/383 (37%)