| Sequence 1: | NP_001262430.1 | Gene: | Calr / 41166 | FlyBaseID: | FBgn0005585 | Length: | 406 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_004334.1 | Gene: | CALR / 811 | HGNCID: | 1455 | Length: | 417 | Species: | Homo sapiens |
| Alignment Length: | 407 | Identity: | 272/407 - (66%) |
|---|---|---|---|
| Similarity: | 321/407 - (78%) | Gaps: | 7/407 - (1%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 6 TVIVLLATVGFISAE--VYLKENF-DNENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEADKGIQ 67
Fly 68 TSQDARFYAASRKFDGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPYEIMF 132
Fly 133 GPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVESGNLE 197
Fly 198 DDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMDGEWE 262
Fly 263 PPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIF 327
Fly 328 DNVLITDDVELAAKAAAEVKN-TQAGEKKMKEAQDEVQRKKDEEEAKKASDKDD-ED-EDDDDEE 389
Fly 390 KDDESKQDKDQSEHDEL 406 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Calr | NP_001262430.1 | Calreticulin | 25..332 | CDD:278680 | 229/307 (75%) |
| CALR | NP_004334.1 | N-domain | 18..197 | 131/179 (73%) | |
| Calreticulin | 23..332 | CDD:395201 | 230/309 (74%) | ||
| 4 X approximate repeats | 191..255 | 53/63 (84%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 193..278 | 69/84 (82%) | |||
| P-domain | 198..308 | 85/109 (78%) | |||
| Interaction with PPIB. /evidence=ECO:0000250 | 237..270 | 28/32 (88%) | |||
| 3 X approximate repeats | 259..297 | 27/37 (73%) | |||
| C-domain | 309..417 | 49/101 (49%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 350..417 | 28/60 (47%) | |||
| Prevents secretion from ER | 414..417 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 383 | 1.000 | Domainoid score | I830 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG0674 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H37911 | |
| Inparanoid | 1 | 1.050 | 570 | 1.000 | Inparanoid score | I1063 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1196 |
| OMA | 1 | 1.010 | - | - | QHG53836 | |
| OrthoDB | 1 | 1.010 | - | - | D351852at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0002317 | |
| OrthoInspector | 1 | 1.000 | - | - | oto91670 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_102266 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11073 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R163 |
| SonicParanoid | 1 | 1.000 | - | - | X1529 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.820 | |||||