DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Calr and Calr3

DIOPT Version :9

Sequence 1:	NP_001262430.1	Gene:	Calr / 41166	FlyBaseID:	FBgn0005585	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_082776.2	Gene:	Calr3 / 73316	MGIID:	1920566	Length:	380	Species:	Mus musculus

Alignment Length:	387	Identity:	170/387 - (43%)
Similarity:	232/387 - (59%)	Gaps:	39/387 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMWCKTVI-VLLATVGFISAEVYLKENF-DNENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEAD 63
            ::|...|: |.|||       ||.:|.| |.|.|.:.|:.|.: ..:||.|.::.|.||...|.|
Mouse     7 LLWAICVLRVALAT-------VYFQEEFLDGERWRNRWVQSTN-DSQFGHFRVSSGKFYGHKEKD 63

  Fly    64 KGIQTSQDARFYAASRKFDGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPY 128
            ||:||:|::||||.|..|..|||:.|.||:|::|||||.:||||||:|:|...|||..|:|:|.|
Mouse    64 KGLQTTQNSRFYAISASFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPSDLDQKKMNGKSQY 128

  Fly   129 EIMFGPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVES 193
            .|||||||||...||||||..:|.:.|...|.||||.|.:||.||||:|||.:|||.:|.:.:||
Mouse   129 YIMFGPDICGFDIKKVHVILYFKNQYHENKKPIRCKVDGFTHLYTLILRPDLSYEVKVDGQSIES 193

  Fly   194 GNLEDDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMD 258
            |::|.||:..:.:| .:.|:....|||      ..:..|.:||:|  |..|..|:||.||:.|:|
Mouse   194 GSIEYDWNLTSLRK-TEKTSLDSRDWD------QVEGSKVQDWEK--HFLDAGASKPSDWNSELD 249

  Fly   259 GEW--EPPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQV 321
            |:|  :||..|..:.:|      :|    |..|.|.::....|:....|...:.|..:|.:||||
Mouse   250 GDWLQKPPYEDGLKAEG------ID----KDVWLHQKMRPAGYLTQYDLSEFENIGAIGLELWQV 304

  Fly   322 KSGTIFDNVLITDDVELAAK-AAAEVKNTQAGEKKMKEAQDEVQRKKDEEEAKKASDKDDED 382
            :|||||||.|||||.|.|.| ..|....|:..||:|    |.:|.|   ||.|||.::|:||
Mouse   305 RSGTIFDNFLITDDEEYAEKFGKATWGETKGPEKEM----DAIQAK---EEVKKAREEDEED 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calr	NP_001262430.1	Calreticulin	25..332	CDD:278680	138/309 (45%)
Calr3	NP_082776.2	N-domain	20..197		95/184 (52%)
		Calreticulin	23..315	CDD:278680	138/311 (44%)
		4 X approximate repeats	191..246		22/63 (35%)
		P-domain	198..291		32/111 (29%)
		3 X approximate repeats	250..280		10/39 (26%)
		C-domain	292..380		37/75 (49%)
		Prevents secretion from ER. /evidence=ECO:0000255	377..380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53836
OrthoDB	1	1.010	-	-		D351852at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.890