DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Calr and Calr4

DIOPT Version :9

Sequence 1:	NP_001262430.1	Gene:	Calr / 41166	FlyBaseID:	FBgn0005585	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_038967098.1	Gene:	Calr4 / 689537	RGDID:	1591090	Length:	444	Species:	Rattus norvegicus

Alignment Length:	392	Identity:	208/392 - (53%)
Similarity:	270/392 - (68%)	Gaps:	21/392 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEADKGIQTSQDARFYAASRKFDGFSNEDKPLVVQ 94
            :.|...|:.|||. .::|||.|..|.||.|.|.|||:||::||:|||.|.:|..||||::.||||
  Rat    41 DGWTKRWVQSKHQ-SDYGKFRLDSGKFYQDKERDKGLQTTEDAKFYALSARFKPFSNENETLVVQ 104

  Fly    95 FSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPYEIMFGPDICGPGTKKVHVIFSYKGKNHLISK 159
            |||||||.|||||||||||..:|:|.|||.||.|.|||||||||.|..::.||..::||.|..:|
  Rat   105 FSVKHEQGIDCGGGYVKLFPATLNQEDMHSESQYYIMFGPDICGFGNNRLQVILYHRGKYHENNK 169

  Fly   160 DIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVESGNLEDDWDFLAPKKIKDPTATKPEDWDDRAT 224
            .::|:.:..||.||||:||:.||||.||||||..|.||.|||||.|||||||.|.||..||:|..
  Rat   170 TLKCRINKDTHLYTLILRPNATYEVKIDNEKVTGGELEADWDFLPPKKIKDPYARKPRKWDERLQ 234

  Fly   225 IPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMDGEWEPPMIDNPEFKGEWQPKQLDNPNYKGAW 289
            |.||:|||||||...|.||||||.||:||::.|||.||.|:|.|.::||||:|:.:|||||:|.|
  Rat   235 IEDPEDKKPEDWQDSEFIPDPDAKKPDDWNEAMDGVWEGPLIPNVKYKGEWKPRIIDNPNYQGEW 299

  Fly   290 EHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIFDNVLITDDVELAAKAAAEVKNTQAG-- 352
            .||||.||:|.||..:.....|..||.||||||||:||||.|:|:|.|.    |.||.|...|
  Rat   300 IHPEIDNPKYRPDPTICHYHNISVLGLDLWQVKSGSIFDNFLLTNDEEF----AEEVGNMTWGLR 360

  Fly   353 ---EKKMKEAQDEVQRKKDEEEAKKASDK-----------DDEDEDDDDEEKDDESKQDKDQSEH 403
               |::.:|..:|::::|:.|||||..:|           |:|||::::|:.::|:::...|...
  Rat   361 KDVEQQWRELYEEMEKQKEAEEAKKKREKQRAKQEDIWGLDEEDEEENEEDAEEEAEERPKQEGS 425

  Fly   404 DE 405
            .|
  Rat   426 GE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calr	NP_001262430.1	Calreticulin	25..332	CDD:278680	181/301 (60%)
Calr4	XP_038967098.1	Calreticulin	41..342	CDD:395201	181/301 (60%)
Calr4	XP_038967098.1	PRK00409	<347..>395	CDD:234750	16/51 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53836
OrthoDB	1	1.010	-	-		D351852at33208
OrthoFinder	1	1.000	-	-		FOG0002317
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11073
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1529
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030