Protein Alignment Calr and Calr

DIOPT Version :10

• Sequence 1: NP_524293.2
• Gene: Calr / 41166
• FlyBaseID: FBgn0005585
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_071794.1
• Gene: Calr / 64202
• RGDID: 620288
• Length: 416
• Species: Rattus norvegicus
• Alignment Length: 414
• Identity: 271/414 - (65%)
• Similarity: 320/414 - (77%)
• Gaps: 14/414 - (3%)

  Fly     6 TVIVLLATVGFISAE--VYLKENF-DNENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEADKGIQ 67
            :|.:||..:|..:|:  :|.||.| |.:.|.:.|:.|||. .:||||||:.|.||.|.|.|||:|
  Rat     4 SVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHK-SDFGKFVLSSGKFYGDQEKDKGLQ 67

  Fly    68 TSQDARFYAASRKFDGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPYEIMF 132
            |||||||||.|.:|:.|||:.:.|||||:|||||||||||||||||...|||.||||:|.|.|||
  Rat    68 TSQDARFYALSARFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPGGLDQKDMHGDSEYNIMF 132

  Fly   133 GPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVESGNLE 197
            ||||||||||||||||:|||||.||:||||||||.:||.|||||||||||||.|||.:||||:||
  Rat   133 GPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLE 197

  Fly   198 DDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMDGEWE 262
            ||||||.|||||||.|.||||||:||.|.||.|.||||||||||||||||.||||||:|||||||
  Rat   198 DDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWE 262

  Fly   263 PPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIF 327
            ||:|.|||:||||:|:|:|||:|||.|.||||.||||.||..:|.......||.|||||||||||
  Rat   263 PPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIF 327

  Fly   328 DNVLITDDVELAAKAAAEVKN-TQAGEKKMKEAQDEVQRKKDEEEAKK------ASDKDDEDEDD 385
            ||.|||:|...|.:...|... |:|.||:||:.|||.||.|:|||.||      |.||:|||:.|
  Rat   328 DNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDEDDRD 392

  Fly   386 DDEEKDDESKQDKDQS---EHDEL 406
            :||:::||.::|::.:   ..|||
  Rat   393 EDEDEEDEKEEDEEDATGQAKDEL 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Calr	NP_524293.2	Calreticulin	25..332	CDD:459737	226/307 (74%)
Calr	NP_071794.1	N-domain	18..197		128/181 (71%)
		Calreticulin	23..332	CDD:459737	228/309 (74%)
		4 X approximate repeats	191..255		52/63 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..277		68/83 (82%)
		P-domain	198..308		83/109 (76%)
		Interaction with PPIB. /evidence=ECO:0000250	237..270		28/32 (88%)
		3 X approximate repeats	259..297		27/37 (73%)
		C-domain	309..416		53/106 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..416		30/64 (47%)
		Prevents secretion from ER	413..416