DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Calr and calr

DIOPT Version :9

Sequence 1:	NP_001262430.1	Gene:	Calr / 41166	FlyBaseID:	FBgn0005585	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_956007.2	Gene:	calr / 325317	ZFINID:	ZDB-GENE-030131-4042	Length:	417	Species:	Danio rerio

Alignment Length:	408	Identity:	253/408 - (62%)
Similarity:	320/408 - (78%)	Gaps:	5/408 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MWCKTVIVLLATVGFISAE--VYLKENF-DNENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEAD 63
            |...:::.:..:|..|:||  ||.:|.| |.::|...|:.|||. .::|||||:.|.||.|||.|
Zfish     1 MTALSLLFMAVSVALITAESNVYFREQFEDGDSWRSRWVESKHK-TDYGKFVLSAGKFYGDAEKD 64

  Fly    64 KGIQTSQDARFYAASRKFDGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPY 128
            ||:||||||.|||.|.:|..|:|:|:|||:||||||||||||||||:|||...|:|.||||:|.|
Zfish    65 KGLQTSQDAHFYAMSARFGDFNNKDQPLVIQFSVKHEQNIDCGGGYIKLFPSDLNQEDMHGDSTY 129

  Fly   129 EIMFGPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVES 193
            .|||||||||||||||||||:||||||||:||||||||.|:|.|||||.|||||||.|||:||||
Zfish   130 NIMFGPDICGPGTKKVHVIFNYKGKNHLINKDIRCKDDEYSHLYTLIVNPDNTYEVKIDNKKVES 194

  Fly   194 GNLEDDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMD 258
            |:||:|||||..||||||.|.||||||:|..|.||:|:|||:|||||:||||||.||:|||:|||
Zfish   195 GSLEEDWDFLPSKKIKDPEAKKPEDWDEREKIDDPEDQKPEEWDKPENIPDPDAKKPDDWDEEMD 259

  Fly   259 GEWEPPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKS 323
            |||||||:.||::||||:|:|:|||.|||.|.||||.||||..|.::|....|..:|.|||||||
Zfish   260 GEWEPPMVTNPDYKGEWKPRQIDNPAYKGKWVHPEIDNPEYTADSEIYKYDSIGVIGLDLWQVKS 324

  Fly   324 GTIFDNVLITDDVELAAKAAAEVKN-TQAGEKKMKEAQDEVQRKKDEEEAKKASDKDDEDEDDDD 387
            ||||||.|||:|.:||.:...|... |:..||||||:|:|..|||.:||.|...::..|:|:::.
Zfish   325 GTIFDNFLITNDPKLAEEVGTETWGATKDAEKKMKESQEEEDRKKHDEEEKSRKEEAKEEEEEEK 389

  Fly   388 EEKDDESKQDKDQSEHDE 405
            ||:|:|.::::::.:.:|
Zfish   390 EEEDEEEEEEEEEEDEEE 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Calr	NP_001262430.1	Calreticulin	25..332	CDD:278680	217/307 (71%)
calr	NP_956007.2	Calreticulin	24..333	CDD:278680	217/309 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	375	1.000	Domainoid score	I831
eggNOG	1	0.900	-	-		E1_KOG0674
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37911
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1072
OMA	1	1.010	-	-		QHG53836
OrthoDB	1	1.010	-	-		D351852at33208
OrthoFinder	1	1.000	-	-		FOG0002317
OrthoInspector	1	1.000	-	-		otm24449
orthoMCL	1	0.900	-	-		OOG6_102266
Panther	1	1.100	-	-	LDO	PTHR11073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R163
SonicParanoid	1	1.000	-	-		X1529
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870