DRSC/TRiP Functional Genomics Resources

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Protein Alignment Calr and Canx

DIOPT Version :10

Sequence 1:NP_524293.2 Gene:Calr / 41166 FlyBaseID:FBgn0005585 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_742005.1 Gene:Canx / 29144 RGDID:2266 Length:591 Species:Rattus norvegicus


Alignment Length:527 Identity:171/527 - (32%)
Similarity:247/527 - (46%) Gaps:153/527 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SAEVYLKENFDNENWEDTWIYS------------KHPGK---EFGKFVLTPGTFYNDAEADKGIQ 67
            :.|||..::||..:... ||.|            |:.||   :..|....||        |||:.
  Rat    67 TGEVYFADSFDRGSLSG-WILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPG--------DKGLV 122

  Fly    68 TSQDARFYAASRKFD-GFSNEDKPLVVQFSVKHEQNIDCGGGYVKLF----DCSLDQTDMHGESP 127
            ....|:.:|.|.|.: .|..:.|||:||:.|..:..|:|||.||||.    :.:|||  .|.::|
  Rat   123 LMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTSELNLDQ--FHDKTP 185

  Fly   128 YEIMFGPDICGPGTKKVHVIFSYKG-------KNHLISKDIRCK---DDVYTHFYTLIVRPDNTY 182
            |.||||||.||. ..|:|.||.:|.       :.|....|...|   .|..||.||||:.|||::
  Rat   186 YTIMFGPDKCGE-DYKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSF 249

  Fly   183 EVLIDNEKVESGNLEDDWDFLAP-----KKIKDPTATKPEDWDDRATIPDPDDKKPEDW------ 236
            |:|:|...|.||||.:|   :.|     ::|:||...||||||:|..|.|||..||:||      
  Rat   250 EILVDQSVVNSGNLLND---MTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPS 311

  Fly   237 ---------------DKPEHIPDPDATKPEDWDDEMDGEWEP-------------------PMID 267
                           |:||:||||||.||||||::||||||.                   ||||
  Rat   312 KIPDEEATKPEGWLDDEPEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMID 376

  Fly   268 NPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIFDNVLI 332
            ||.:||:|:|..:|||||:|.|:..:|.||::..|.:.:.......:|.:||.:.|...|||.:|
  Rat   377 NPNYKGKWKPPMIDNPNYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFII 441

  Fly   333 TDD-------------VELAAKAAAE--------------------------------------- 345
            :.|             ::.||..|||                                       
  Rat   442 SGDRRVVDDWANDGWGLKKAADGAAEPGVVGQMLEAAEERPWLWVVYILTVALPVFLVILFCCSG 506

  Fly   346 VKNTQAGEKKMKEA-QDEVQRKKDEEEAKKASDKDDEDEDDDDEEKDD----------ESKQDKD 399
            .|.:.|.|.|..:| |.:|:.::.:||.|...|:::|:|..::::|.|          :.:..|.
  Rat   507 KKQSNAMEYKKTDAPQPDVKDEEGKEEEKNKGDEEEEEEKLEEKQKSDAEEDGGTGSQDEEDSKP 571

  Fly   400 QSEHDEL 406
            ::|.||:
  Rat   572 KAEEDEI 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalrNP_524293.2 Calreticulin 25..332 CDD:459737 142/381 (37%)
CanxNP_742005.1 Calreticulin 72..441 CDD:459737 142/383 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..347 38/88 (43%)
P domain (Extended arm). /evidence=ECO:0000250 277..410 59/132 (45%)
4 X approximate repeats 279..346 32/66 (48%)
Interaction with PPIB. /evidence=ECO:0000250 327..360 21/32 (66%)
4 X approximate repeats 349..406 22/56 (39%)
Sufficient to mediate interaction with SGIP1. /evidence=ECO:0000250 504..591 19/75 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..591 17/65 (26%)

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