DRSC/TRiP Functional Genomics Resources

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Protein Alignment Calr and CALR3

DIOPT Version :10

Sequence 1:NP_524293.2 Gene:Calr / 41166 FlyBaseID:FBgn0005585 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_659483.2 Gene:CALR3 / 125972 HGNCID:20407 Length:384 Species:Homo sapiens


Alignment Length:387 Identity:163/387 - (42%)
Similarity:237/387 - (61%) Gaps:27/387 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MWCKTVI-VLLATVGFISAEVYLKENF-DNENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEADK 64
            :|...:: |.|||       ||.:|.| |.|:|.:.|:.|.:..: ||.|.|:.|.||...|.||
Human     8 LWAICMLRVALAT-------VYFQEEFLDGEHWRNRWLQSTNDSR-FGHFRLSSGKFYGHKEKDK 64

  Fly    65 GIQTSQDARFYAASRKFDGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPYE 129
            |:||:|:.||||.|.:|..|||:.|.||:|::|||||.:||||||:|:|...:||.:::|:|.|.
Human    65 GLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYY 129

  Fly   130 IMFGPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVESG 194
            |||||||||...||||||..:|.|.|...|.||||.|.:||.||||:|||.:|:|.||.:.:|||
Human   130 IMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESG 194

  Fly   195 NLEDDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMDG 259
            ::|.||:..:.||...|..:|  ||:      ...|.|.:||:|  |..|...:|..||:.::||
Human   195 SIEYDWNLTSLKKETSPAESK--DWE------QTKDNKAQDWEK--HFLDASTSKQSDWNGDLDG 249

  Fly   260 EWEPPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSG 324
            :|..||:..|.::...:|:.:    :|..|.|.::.|.:|:....|...:.|..:|.:||||:||
Human   250 DWPAPMLQKPPYQDGLKPEGI----HKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSG 310

  Fly   325 TIFDNVLITDDVELAAK-AAAEVKNTQAGEKKMK--EAQDEVQRKKDEEEAKKASDKDDEDE 383
            |||||.|||||.|.|.. ..|....|:..|::|.  :|::|:::.::|||.:..|.|.:..|
Human   311 TIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHE 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalrNP_524293.2 Calreticulin 25..332 CDD:459737 137/307 (45%)
CALR3NP_659483.2 N-domain 20..197 95/184 (52%)
Calreticulin 23..318 CDD:459737 137/309 (44%)
4 X approximate repeats 191..245 22/63 (35%)
P-domain 198..294 31/109 (28%)
3 X approximate repeats 249..283 9/37 (24%)
C-domain 295..384 32/78 (41%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 381..384
Blue background indicates that the domain is not in the aligned region.

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