DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Calr and Canx

DIOPT Version :9

Sequence 1:NP_001262430.1 Gene:Calr / 41166 FlyBaseID:FBgn0005585 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_001103969.1 Gene:Canx / 12330 MGIID:88261 Length:591 Species:Mus musculus


Alignment Length:527 Identity:172/527 - (32%)
Similarity:242/527 - (45%) Gaps:153/527 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SAEVYLKENFDNENWEDTWIYS------------KHPGK---EFGKFVLTPGTFYNDAEADKGIQ 67
            :.|||..::||..:... ||.|            |:.||   :..|....||        |||:.
Mouse    67 TGEVYFADSFDRGSLSG-WILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPG--------DKGLV 122

  Fly    68 TSQDARFYAASRKFD-GFSNEDKPLVVQFSVKHEQNIDCGGGYVKLF----DCSLDQTDMHGESP 127
            ....|:.:|.|.|.: .|..:.|||:||:.|..:..|:|||.||||.    :.||||  .|.::|
Mouse   123 LMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTAELSLDQ--FHDKTP 185

  Fly   128 YEIMFGPDICGPGTKKVHVIFSYKG-------KNHLISKDIRCK---DDVYTHFYTLIVRPDNTY 182
            |.||||||.||. ..|:|.||.:|.       :.|....|...|   .|..||.||||:.|||::
Mouse   186 YTIMFGPDKCGE-DYKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSF 249

  Fly   183 EVLIDNEKVESGNLEDDWDFLAP-----KKIKDPTATKPEDWDDRATIPDPDDKKPEDW------ 236
            |:|:|...|.||||.:|   :.|     ::|:||...||||||:|..|.|||..||:||      
Mouse   250 EILVDQSVVNSGNLLND---MTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPS 311

  Fly   237 ---------------DKPEHIPDPDATKPEDWDDEMDGEWEP-------------------PMID 267
                           |:||:||||||.||||||::||||||.                   ||||
Mouse   312 KIPDEEATKPEGWLDDEPEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMID 376

  Fly   268 NPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIFDNVLI 332
            ||.:||:|:|..:|||||:|.|:..:|.||::..|.:.:.......:|.:||.:.|...|||.:|
Mouse   377 NPNYKGKWKPPMIDNPNYQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFII 441

  Fly   333 TDD-------------VELAAKAAA---------------------------------------- 344
            :.|             ::.||..||                                        
Mouse   442 SGDRRVVDDWANDGWGLKKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCCSG 506

  Fly   345 -------EVKNTQAGEKKMK--EAQDEVQRKKD-EEEAKKASDKDDEDEDDDDEEKDDESKQDKD 399
                   |.|.|.|.:..:|  |.::|.:.|:| |||.:|..:|...|.::|......:.:..|.
Mouse   507 KKQSNAMEYKKTDAPQPDVKDEEGKEEEKNKRDEEEEEEKLEEKQKSDAEEDGVTGSQDEEDSKP 571

  Fly   400 QSEHDEL 406
            ::|.||:
Mouse   572 KAEEDEI 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalrNP_001262430.1 Calreticulin 25..332 CDD:278680 143/381 (38%)
CanxNP_001103969.1 Calreticulin 72..441 CDD:278680 143/383 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..347 38/88 (43%)
P domain (Extended arm). /evidence=ECO:0000250 277..410 59/132 (45%)
4 X approximate repeats 279..346 32/66 (48%)
Interaction with PPIB. /evidence=ECO:0000250 327..360 21/32 (66%)
4 X approximate repeats 349..406 22/56 (39%)
Sufficient to mediate interaction with SGIP1. /evidence=ECO:0000269|PubMed:21747946 504..591 20/75 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..591 20/65 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R163
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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