DRSC/TRiP Functional Genomics Resources

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Protein Alignment Calr and Canx

DIOPT Version :10

Sequence 1:NP_524293.2 Gene:Calr / 41166 FlyBaseID:FBgn0005585 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_031623.1 Gene:Canx / 12330 MGIID:88261 Length:591 Species:Mus musculus


Alignment Length:527 Identity:172/527 - (32%)
Similarity:242/527 - (45%) Gaps:153/527 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SAEVYLKENFDNENWEDTWIYS------------KHPGK---EFGKFVLTPGTFYNDAEADKGIQ 67
            :.|||..::||..:... ||.|            |:.||   :..|....||        |||:.
Mouse    67 TGEVYFADSFDRGSLSG-WILSKAKKDDTDDEIAKYDGKWEVDEMKETKLPG--------DKGLV 122

  Fly    68 TSQDARFYAASRKFD-GFSNEDKPLVVQFSVKHEQNIDCGGGYVKLF----DCSLDQTDMHGESP 127
            ....|:.:|.|.|.: .|..:.|||:||:.|..:..|:|||.||||.    :.||||  .|.::|
Mouse   123 LMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTAELSLDQ--FHDKTP 185

  Fly   128 YEIMFGPDICGPGTKKVHVIFSYKG-------KNHLISKDIRCK---DDVYTHFYTLIVRPDNTY 182
            |.||||||.||. ..|:|.||.:|.       :.|....|...|   .|..||.||||:.|||::
Mouse   186 YTIMFGPDKCGE-DYKLHFIFRHKNPKTGVYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSF 249

  Fly   183 EVLIDNEKVESGNLEDDWDFLAP-----KKIKDPTATKPEDWDDRATIPDPDDKKPEDW------ 236
            |:|:|...|.||||.:|   :.|     ::|:||...||||||:|..|.|||..||:||      
Mouse   250 EILVDQSVVNSGNLLND---MTPPVNPSREIEDPEDRKPEDWDERPKIADPDAVKPDDWDEDAPS 311

  Fly   237 ---------------DKPEHIPDPDATKPEDWDDEMDGEWEP-------------------PMID 267
                           |:||:||||||.||||||::||||||.                   ||||
Mouse   312 KIPDEEATKPEGWLDDEPEYIPDPDAEKPEDWDEDMDGEWEAPQIANPKCESAPGCGVWQRPMID 376

  Fly   268 NPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIFDNVLI 332
            ||.:||:|:|..:|||||:|.|:..:|.||::..|.:.:.......:|.:||.:.|...|||.:|
Mouse   377 NPNYKGKWKPPMIDNPNYQGIWKPRKIPNPDFFEDLEPFKMTPFSAIGLELWSMTSDIFFDNFII 441

  Fly   333 TDD-------------VELAAKAAA---------------------------------------- 344
            :.|             ::.||..||                                        
Mouse   442 SGDRRVVDDWANDGWGLKKAADGAAEPGVVLQMLEAAEERPWLWVVYILTVALPVFLVILFCCSG 506

  Fly   345 -------EVKNTQAGEKKMK--EAQDEVQRKKD-EEEAKKASDKDDEDEDDDDEEKDDESKQDKD 399
                   |.|.|.|.:..:|  |.::|.:.|:| |||.:|..:|...|.::|......:.:..|.
Mouse   507 KKQSNAMEYKKTDAPQPDVKDEEGKEEEKNKRDEEEEEEKLEEKQKSDAEEDGVTGSQDEEDSKP 571

  Fly   400 QSEHDEL 406
            ::|.||:
Mouse   572 KAEEDEI 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalrNP_524293.2 Calreticulin 25..332 CDD:459737 143/381 (38%)
CanxNP_031623.1 Calreticulin 72..441 CDD:459737 143/383 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..347 38/88 (43%)
P domain (Extended arm). /evidence=ECO:0000250 277..410 59/132 (45%)
4 X approximate repeats 279..346 32/66 (48%)
Interaction with PPIB. /evidence=ECO:0000250 327..360 21/32 (66%)
4 X approximate repeats 349..406 22/56 (39%)
Sufficient to mediate interaction with SGIP1. /evidence=ECO:0000269|PubMed:21747946 504..591 20/75 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..591 20/65 (31%)

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