DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Calr and Calr

DIOPT Version :9

Sequence 1:NP_001262430.1 Gene:Calr / 41166 FlyBaseID:FBgn0005585 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_031617.1 Gene:Calr / 12317 MGIID:88252 Length:416 Species:Mus musculus


Alignment Length:414 Identity:272/414 - (65%)
Similarity:321/414 - (77%) Gaps:14/414 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TVIVLLATVGFISAE--VYLKENF-DNENWEDTWIYSKHPGKEFGKFVLTPGTFYNDAEADKGIQ 67
            :|.:||..:|..:|:  :|.||.| |.:.|.:.|:.|||. .:||||||:.|.||.|.|.|||:|
Mouse     4 SVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHK-SDFGKFVLSSGKFYGDLEKDKGLQ 67

  Fly    68 TSQDARFYAASRKFDGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTDMHGESPYEIMF 132
            |||||||||.|.||:.|||:.:.|||||:|||||||||||||||||...|||.||||:|.|.|||
Mouse    68 TSQDARFYALSAKFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPSGLDQKDMHGDSEYNIMF 132

  Fly   133 GPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIVRPDNTYEVLIDNEKVESGNLE 197
            ||||||||||||||||:|||||.||:||||||||.:||.|||||||||||||.|||.:||||:||
Mouse   133 GPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLE 197

  Fly   198 DDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDKPEHIPDPDATKPEDWDDEMDGEWE 262
            ||||||.|||||||.|.||||||:||.|.||.|.||||||||||||||||.||||||:|||||||
Mouse   198 DDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWE 262

  Fly   263 PPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIF 327
            ||:|.|||:||||:|:|:|||:|||.|.||||.||||.||..:|.......||.|||||||||||
Mouse   263 PPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIF 327

  Fly   328 DNVLITDDVELAAKAAAEVKN-TQAGEKKMKEAQDEVQRKKDEEEAKK------ASDKDDEDEDD 385
            ||.|||:|...|.:...|... |:|.||:||:.|||.||.|:|||.||      |.||:|:|:.|
Mouse   328 DNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDDDRD 392

  Fly   386 DDEEKDDESKQDKDQS---EHDEL 406
            :||:::||.::|:::|   ..|||
Mouse   393 EDEDEEDEKEEDEEESPGQAKDEL 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalrNP_001262430.1 Calreticulin 25..332 CDD:278680 227/307 (74%)
CalrNP_031617.1 N-domain 18..197 129/181 (71%)
Calreticulin 23..332 CDD:278680 229/309 (74%)
4 X approximate repeats 191..255 52/63 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..278 68/84 (81%)
P-domain 198..308 83/109 (76%)
Interaction with PPIB. /evidence=ECO:0000269|PubMed:20801878 237..270 28/32 (88%)
3 X approximate repeats 259..297 27/37 (73%)
C-domain 309..416 53/106 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..416 30/64 (47%)
Prevents secretion from ER 413..416


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 381 1.000 Domainoid score I839
eggNOG 1 0.900 - - E1_KOG0674
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37911
Inparanoid 1 1.050 568 1.000 Inparanoid score I1066
Isobase 1 0.950 - 0 Normalized mean entropy S1196
OMA 1 1.010 - - QHG53836
OrthoDB 1 1.010 - - D351852at33208
OrthoFinder 1 1.000 - - FOG0002317
OrthoInspector 1 1.000 - - oto95251
orthoMCL 1 0.900 - - OOG6_102266
Panther 1 1.100 - - LDO PTHR11073
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R163
SonicParanoid 1 1.000 - - X1529
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.820

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