DRSC/TRiP Functional Genomics Resources

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Protein Alignment Calr and CLGN

DIOPT Version :10

Sequence 1:NP_524293.2 Gene:Calr / 41166 FlyBaseID:FBgn0005585 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_004353.1 Gene:CLGN / 1047 HGNCID:2060 Length:610 Species:Homo sapiens


Alignment Length:518 Identity:164/518 - (31%)
Similarity:236/518 - (45%) Gaps:141/518 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 EVYLKENFDNENWEDTWIYSKHPGKEFGKFVLTPGTFY-----------NDAEADKGIQTSQDAR 73
            |||..|.||:..... |:.||....:..:.:    :.|           |....|:|:.....|:
Human    59 EVYFAETFDSGRLAG-WVLSKAKKDDMDEEI----SIYDGRWEIEELKENQVPGDRGLVLKSRAK 118

  Fly    74 FYAASRKF-DGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCSLDQTD------MHGESPYEIM 131
            .:|.|... ..|...||||:||:.|..:..|||||.|:||    |..||      .:.::.|.||
Human   119 HHAISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKL----LADTDDLILENFYDKTSYIIM 179

  Fly   132 FGPDICGPGTKKVHVIFSYK-------GKNHLISKDIRCK---DDVYTHFYTLIVRPDNTYEVLI 186
            ||||.||. ..|:|.||.:|       .:.|....|:..|   .|..||.|||::.||:|:|||:
Human   180 FGPDKCGE-DYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLV 243

  Fly   187 DNEKVESGNLEDDW--DFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDW------------- 236
            |...|..|:|.:|.  ....||:|:||...|||:||:||.||||...|||||             
Human   244 DQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEPAQIEDSSV 308

  Fly   237 --------DKPEHIPDPDATKPEDWDDEMDGEWE-----------------PPMIDNPEFKGEWQ 276
                    |:|:.||||:|.||:||:::.|||||                 |||||||::||.|:
Human   309 VKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACRIGCGEWKPPMIDNPKYKGVWR 373

  Fly   277 PKQLDNPNYKGAWEHPEIANPEYVPDDKLYLRKEICTLGFDLWQVKSGTIFDNVLITDDVELAAK 341
            |..:|||||:|.|...:|.||:|..||..:|......||.:||.:.|...|||.:|..:.|:|..
Human   374 PPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTSDIYFDNFIICSEKEVADH 438

  Fly   342 AAAE----------------VKNTQAG---------------------------EKKMKEAQDEV 363
            .||:                :|...|.                           .:|:|:...:.
Human   439 WAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTAGVPIALITSFCWPRKVKKKHKDT 503

  Fly   364 QRKK-------------DEEEAKKAS-----DKDDEDEDDDDE--EKDDESKQDKDQSEHDEL 406
            :.||             .||:.:||:     |.::|.:.:|.|  ||::||:.::...|..|:
Human   504 EYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEKKQNDGEMLEKEEESEPEEKSEEEIEI 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalrNP_524293.2 Calreticulin 25..332 CDD:459737 136/374 (36%)
CLGNNP_004353.1 Calreticulin 62..429 CDD:459737 136/376 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 258..338 32/79 (41%)
Interaction with PPIB. /evidence=ECO:0000250 317..350 16/32 (50%)
2-1 339..352 4/12 (33%)
2-2 356..369 7/12 (58%)
2-3 370..383 7/12 (58%)
2-4 384..397 5/12 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..610 14/46 (30%)

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