DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8319 and Sry-beta

DIOPT Version :9

Sequence 1:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	86/410 - (20%)
Similarity:	141/410 - (34%)	Gaps:	139/410 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CRICGGASENMLGIFDDQVEEYVDGAKLAEMVKTCADV------------QLDPDDAMPQKMCIS 57
            |.:||  .|..:|:|     :.::|..:....|...|:            :|.|:.|    .|..
  Fly     8 CFVCG--KEKSVGVF-----QLIEGCIVPGTFKPIKDILKYFEKIINQRLELLPNSA----ACRD 61

  Fly    58 CVH-------------------------------DARTAYGFKRRCEENYKKFYLAILNGQVIKD 91
            |:.                               .|.|.....:|.......|  .|:....:|:
  Fly    62 CLEYLFNYDRLVRNLSQVQRQIADALLGCRQVEGKAETKQQAAKRARVQVPAF--KIVQATALKE 124

  Fly    92 ---EPNEED--------------FLFIENPDKGNLEAKKKLNKEIKKTHQTASRTTKSSITTSRA 139
               :|.|||              |.|.| ||.....::::...|          ||:
  Fly   125 PERQPGEEDECEEFMKEEMLDEEFQFSE-PDDSMPSSEEEFFTE----------TTE-------- 170

  Fly   140 GRQLRSIKNQTFKCELCIKQFKRQINLLDHMKVHSNSHVCQNCEERFLFKADLDNHQCYRNSNST 204
                       ..|.:|.:.|..|..|..|:|    :..||..|:
  Fly   171 -----------IPCHICGEMFSSQEVLERHIK----ADTCQKSEQ-------------------- 200

  Fly   205 VECPEC-LKVFSSTQSLDSHKCKDMQE-RSPFQCPHCQQAFTREQNLKAHLLIHAESKQGNGPHK 267
            ..|..| ||| ...:.||.|  .::.| ::..:|.:|.:.|:.::|:..|:.:|.:.|:    ::
  Fly   201 ATCNVCGLKV-KDDEVLDLH--MNLHEGKTELECRYCDKKFSHKRNVLRHMEVHWDKKK----YQ 258

  Fly   268 CSYCQTGFFNKSALKVHIHAH-MGERPHACPFCVSNFRSKQALKVHIRIHTGEKP-YQCPHCPKT 330
            |..|...|.....:..|:..| ..|....|..|...|::|:..|.|:|.|..::| |.||.|.|:
  Fly   259 CDKCGERFSLSWLMYNHLMRHDAEENALICEVCHQQFKTKRTYKHHLRTHQTDRPRYPCPDCEKS 323

  Fly   331 FSDNNNLAKHRRRHSD-ERP 349
            |.|...|..|:|.|.. |:|
  Fly   324 FVDKYTLKVHKRVHQPVEKP 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	17/116 (15%)
		COG5048	<153..368	CDD:227381	54/202 (27%)
		C2H2 Zn finger	153..173	CDD:275368	7/19 (37%)
		C2H2 Zn finger	179..196	CDD:275368	3/16 (19%)
		C2H2 Zn finger	207..227	CDD:275370	8/20 (40%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	268..288	CDD:275368	4/19 (21%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..332	CDD:290200	10/24 (42%)
		zf-C2H2	322..344	CDD:278523	10/21 (48%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		C2H2 Zn finger	352..368	CDD:275368
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	8/22 (36%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		C2H2 Zn finger	259..308	CDD:275368	13/48 (27%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	10/21 (48%)
		C2H2 Zn finger	317..337	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449798
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930