DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8319 and Plzf

DIOPT Version :9

Sequence 1:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001285862.1	Gene:	Plzf / 34622	FlyBaseID:	FBgn0032401	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	100/397 - (25%)
Similarity:	157/397 - (39%)	Gaps:	74/397 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VQLDPDDAM-----------------------------PQKM------CISCVHDARTAYGF--- 68
            ::||.||::                             |.|:      |..|:|   |...|
  Fly    39 LELDSDDSLSLSVHFCVLAAQSQFINSNQKQQQFSIHNPLKITIRNFSCTQCLH---TIVDFFYE 100

  Fly    69 -----KRRCEENYKKF--YLAI---LNGQVIKDEPNEEDFLFIENPDKGNLEAKKKLNKEIKKTH 123
                 .:..|.::::.  .||:   ||  :.:.:|..|.....|.|..|  ||:...:.|.|...
  Fly   101 DLVSVSKEHELHFRELAQILAVTELLN--LYQLQPLGEAKEATEIPAPG--EAQPNPDPEKKAEA 161

  Fly   124 QTASRTTKSSITTSRAGRQLRSIKNQTFKCELCIKQFKRQINLLDHMKVHSNSH-VCQNCEERFL 187
            ...:|.:...:...||.:....: |....|:....|.::   :::||.....|| :|..||..||
  Fly   162 VFENRQSYFKLKNPRAVKSSSKV-NYCIGCDFKCYQVQK---MIEHMGSCEPSHLICSLCEVGFL 222

  Fly   188 FKADLDNHQCYRNSNSTVE---CPECLKVFSSTQSLDSHKCKDMQERSPFQCPHCQQAFTREQNL 249
            ...:.|.| ..|:|....:   |.:|...|::..:|..|:.|...| :|..||||.:.|..:|.|
  Fly   223 DWREYDTH-LRRHSGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTE-TPHICPHCGKGFKWKQGL 285

  Fly   250 KAHLLIHAESKQGNGPHKCSYCQTGFFNKSALKVHIHAHMGERPHACPF--CVSNFRSKQALKVH 312
            ..|:|:|...||    ..|..|.....:..|||.|...|.||. .||..  |......|:.||:|
  Fly   286 SNHILVHNPEKQ----MLCDVCGYSTTHMKALKSHKLLHTGEF-FACTVSGCKHRANRKENLKLH 345

  Fly   313 IRIHTGEKPYQCPHCPKTFSDNNNLAKHRRRHSDERP--YKCSICLQDFREKHHLKRHFLGKHRD 375
            |..|...:.:.|..|...||.:.||.:|..:|::..|  |||.:|.........:|.|....|.:
  Fly   346 IETHKQGRDFICEVCGCKFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEHVQRVHTE 410

  Fly   376 GDQKLKL 382
            ...:|:|
  Fly   411 KPVQLEL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	12/79 (15%)
		COG5048	<153..368	CDD:227381	67/222 (30%)
		C2H2 Zn finger	153..173	CDD:275368	4/19 (21%)
		C2H2 Zn finger	179..196	CDD:275368	6/16 (38%)
		C2H2 Zn finger	207..227	CDD:275370	5/19 (26%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		C2H2 Zn finger	296..316	CDD:275368	7/21 (33%)
		zf-H2C2_2	308..332	CDD:290200	7/23 (30%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..368	CDD:275368	3/15 (20%)
Plzf	NP_001285862.1	COG5048	<193..403	CDD:227381	66/219 (30%)
		C2H2 Zn finger	214..234	CDD:275368	7/20 (35%)
		C2H2 Zn finger	244..264	CDD:275368	5/19 (26%)
		C2H2 Zn finger	272..292	CDD:275368	9/19 (47%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..349	CDD:275368	6/18 (33%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..408	CDD:275368	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930