DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8319 and ZNF850

DIOPT Version :9

Sequence 1:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	407	Identity:	109/407 - (26%)
Similarity:	163/407 - (40%)	Gaps:	69/407 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CRICGGASENMLGIFDDQVEEYVDGAKLAEMVKTCADVQLDPDDAMPQKMCIS---CVHDARTAY 66
            |:.||.|..::.|:  .|......|.|..|    |.|.    ..|..|:..::   .:|.....|
Human   647 CQECGKAFVSVSGL--TQHHRIHTGEKPYE----CPDC----GKAFRQRTYLNQHRRIHTGEKPY 701

  Fly    67 GFKRRCEENYKKFYLAILNGQVIKDEPNEEDFLFIENPDKGNLEAKKKLNKEIKKTHQTASRTTK 131
                .|:|..|.|  ...:| :|:.:.|..|    |.|..|. |..|...............|.:
Human   702 ----ECKECGKSF--TFCSG-LIQHQQNHTD----EKPYDGK-ECGKSFTSHSTLIQHQQIHTGE 754

  Fly   132 SSITTSRAGRQLRS----IKNQ-------TFKCELCIKQFKRQINLLDHMKVHSNS--HVCQNCE 183
            ........|:...|    |::|       .:.|:.|.|.|.....|:.|..:|:..  :.|:.|.
Human   755 KPYDCKECGKSFTSHSTLIQHQQIHTGEKLYDCKECGKSFTSHSTLIQHQPLHTGEKPYHCKECG 819

  Fly   184 ERFLFKADLDNHQCYRNSNSTVECPECLKVFSSTQSLDSHK----------CKD----------- 227
            :.|..::.|..|:..........|.||.|.|:|..:|..|:          ||:
Human   820 KSFTLRSALIQHRPVHTGEKRYSCKECGKSFTSRSTLIEHQRIHTGEKPYHCKECGKSFAFRSAI 884

  Fly   228 MQER------SPFQCPHCQQAFTREQNLKAHLLIHAESKQGNGPHKCSYCQTGFFNKSALKVHIH 286
            :|.|      .|:.|..|.:||.|...|..|..||.    |..|::|..|...|...|.|..|..
Human   885 IQHRRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHT----GEKPYRCHECGKAFVRFSGLTKHHS 945

  Fly   287 AHMGERPHACPFCVSNFRSKQALKVHIRIHTGEKPYQCPHCPKTFSDNNNLAKHRRRHSDERPYK 351
            .|.||:|:.|..|..:||.:..|.:|.|||||::||:|..|.|:|:..:.|.:|:|.|:.|:||.
Human   946 IHTGEKPYECKTCGKSFRQRTHLTLHQRIHTGDRPYECKECGKSFTCGSELIRHQRTHTGEKPYD 1010

  Fly   352 CSICLQDFREKHHLKRH 368
            |..|.:.||....|.:|
Human  1011 CKECGKAFRCPSQLSQH 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	18/76 (24%)
		COG5048	<153..368	CDD:227381	75/243 (31%)
		C2H2 Zn finger	153..173	CDD:275368	6/19 (32%)
		C2H2 Zn finger	179..196	CDD:275368	4/16 (25%)
		C2H2 Zn finger	207..227	CDD:275370	9/29 (31%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..332	CDD:290200	12/23 (52%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..368	CDD:275368	5/15 (33%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	4/11 (36%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	436..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..487	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		zf-H2C2_2	493..516	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368
		zf-H2C2_2	519..543	CDD:290200
		COG5048	531..947	CDD:227381	75/325 (23%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	575..599	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		zf-H2C2_2	632..656	CDD:290200	4/8 (50%)
		C2H2 Zn finger	647..667	CDD:275368	6/21 (29%)
		zf-H2C2_2	660..684	CDD:290200	7/33 (21%)
		C2H2 Zn finger	675..695	CDD:275368	4/23 (17%)
		zf-H2C2_2	687..711	CDD:290200	6/29 (21%)
		C2H2 Zn finger	703..723	CDD:275368	6/22 (27%)
		C2H2 Zn finger	732..751	CDD:275368	2/19 (11%)
		C2H2 Zn finger	759..779	CDD:275368	4/19 (21%)
		C2H2 Zn finger	787..807	CDD:275368	6/19 (32%)
		C2H2 Zn finger	815..835	CDD:275368	5/19 (26%)
		C2H2 Zn finger	843..863	CDD:275368	8/19 (42%)
		zf-H2C2_2	856..879	CDD:290200	4/22 (18%)
		C2H2 Zn finger	871..891	CDD:275368	4/19 (21%)
		C2H2 Zn finger	899..919	CDD:275368	7/19 (37%)
		zf-H2C2_2	912..936	CDD:290200	9/27 (33%)
		C2H2 Zn finger	927..947	CDD:275368	6/19 (32%)
		C2H2 Zn finger	955..975	CDD:275368	7/19 (37%)
		zf-H2C2_2	967..992	CDD:290200	13/24 (54%)
		C2H2 Zn finger	983..1003	CDD:275368	7/19 (37%)
		zf-H2C2_2	995..1020	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1011..1031	CDD:275368	6/17 (35%)
		zf-H2C2_2	1024..1046	CDD:290200	2/4 (50%)
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000