DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8319 and E4F1

DIOPT Version :9

Sequence 1:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	XP_005255212.1	Gene:	E4F1 / 1877	HGNCID:	3121	Length:	837	Species:	Homo sapiens

Alignment Length:	169	Identity:	56/169 - (33%)
Similarity:	86/169 - (50%)	Gaps:	5/169 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 TVECPECLKVFSSTQSLDSHKCKDMQERSPFQCPHCQQAFTREQNLKAHLLIHAESKQGNGPHKC 268
            |..||:|.:.|.:..:|::||......| ||.|..|.:||.:...||.|..:|...::    .:|
Human   487 THPCPQCSETFPTAATLEAHKRGHTGPR-PFACAQCGKAFPKAYLLKKHQEVHVRERR----FRC 546

  Fly   269 SYCQTGFFNKSALKVHIHAHMGERPHACPFCVSNFRSKQALKVHIRIHTGEKPYQCPHCPKTFSD 333
            ..|...:...:.::.|...|..|||:.||.|...:::|.|.:||.|.|..|||:.|..|.:.|.:
Human   547 GDCGKLYKTIAHVRGHRRVHSDERPYPCPKCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFRE 611

  Fly   334 NNNLAKHRRRHSDERPYKCSICLQDFREKHHLKRHFLGK 372
            ..:|.:|.|.|:.|:|:||..|.:.|.|...|.||...|
Human   612 KGSLVRHVRHHTGEKPFKCYKCGRGFAEHGTLNRHLRTK 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071
		COG5048	<153..368	CDD:227381	53/163 (33%)
		C2H2 Zn finger	153..173	CDD:275368
		C2H2 Zn finger	179..196	CDD:275368
		C2H2 Zn finger	207..227	CDD:275370	7/19 (37%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	268..288	CDD:275368	3/19 (16%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		zf-H2C2_2	308..332	CDD:290200	10/23 (43%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..368	CDD:275368	5/15 (33%)
E4F1	XP_005255212.1	COG5048	236..648	CDD:227381	55/165 (33%)
		C2H2 Zn finger	247..267	CDD:275368
		zf-C2H2	273..295	CDD:278523
		C2H2 Zn finger	275..295	CDD:275368
		zf-H2C2_2	287..310	CDD:290200
		zf-C2H2	301..322	CDD:278523
		C2H2 Zn finger	303..321	CDD:275368
		C2H2 Zn finger	490..510	CDD:275368	7/19 (37%)
		DUF45	<506..585	CDD:302795	23/83 (28%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		C2H2 Zn finger	546..566	CDD:275368	3/19 (16%)
		zf-H2C2_2	558..583	CDD:290200	8/24 (33%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
		zf-H2C2_2	588..609	CDD:290200	9/20 (45%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		zf-H2C2_2	614..638	CDD:290200	9/23 (39%)
		C2H2 Zn finger	630..649	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910