DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8319 and ZK546.5

DIOPT Version :9

Sequence 1:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001364799.1	Gene:	ZK546.5 / 173850	WormBaseID:	WBGene00022762	Length:	581	Species:	Caenorhabditis elegans

Alignment Length:	415	Identity:	83/415 - (20%)
Similarity:	125/415 - (30%)	Gaps:	140/415 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KRRCEENYKKFYLAILNGQVIKDEPNEEDFLFIENPDKG--NLEAKKKLNKEIKKTHQTASRTTK 131
            |.|.|....:...|:|.|               ..|..|  ..||....|..:...|.||   .:
Worm   134 KMRHEARAHQLVKAVLAG---------------NQPTVGGEQYEACTICNMLVNIAHPTA---ME 180

  Fly   132 SSITTSRAGRQLR----------SIKNQTFKCELCIKQFKRQINLLDHMKVH---SNSHVCQNC- 182
            |.....:...:||          .::|.|  ||||...|.....|..|:..|   ...::|:.|
Worm   181 SHQRAHKKNDELRLQLIDRLGAHEVQNLT--CELCSLVFPDDGKLRAHVTSHHTRRKKYICKFCG 243

  Fly   183 ------EERFLFKADLDNHQCYRNSNSTVECPECLKVFSSTQSLDSHKCKDMQERSPFQ------ 235
                  .|..|.|.|:.|:..:.|      .||.||...:....|..: |.::.|:.|:
Worm   244 HISHSMSELNLHKNDVHNYTAWAN------VPEYLKSRRTFYQYDEEQ-KRLRRRTNFEMADEMS 301

  Fly   236 -------------------CPHCQQAFTREQNLKAHL-LIHAESKQGNGPHKCSYCQTGFFNKSA 280
                               ||.|.....|.:.|..|: .:|.:|.     ..| ..:||......
Worm   302 IRLPILGEISDGDTAGRVTCPECGLKLNRPRLLFKHMERVHMKSS-----FSC-MVETGGLPTFE 360

  Fly   281 LKVHIHAHMGERPHACPFCVSNFRSKQALKVHIRIH-----------TGEKPYQCPHCPKTFSDN 334
            |:|    ..||....|  |.|.|.::.....|.|:|           :.|.|...|...:....:
Worm   361 LEV----SNGEIFWTC--CDSKFDNRPEFIEHRRLHIPTQHEEVVVESSEDPNDIPSTSQAMIPD 419

  Fly   335 NNLAKHRRRHS------DERPYKCSICL---QDFRE-------------------------KHHL 365
            .:..:...:|:      ||.. ...:.|   .|.||                         .|||
Worm   420 EDANEAAEQHNFPQMIHDEHG-NIQVLLPEGYDLRETYYIYDENGTKIQLVPLQQPDGTIDHHHL 483

  Fly   366 KRHFLGKH-------RDGDQKLKLK 383
            ...|...|       .:||:.:.|:
Worm   484 VPQFEINHEGEEQIIEEGDEMMALE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	3/9 (33%)
		COG5048	<153..368	CDD:227381	59/295 (20%)
		C2H2 Zn finger	153..173	CDD:275368	7/19 (37%)
		C2H2 Zn finger	179..196	CDD:275368	7/23 (30%)
		C2H2 Zn finger	207..227	CDD:275370	5/19 (26%)
		C2H2 Zn finger	236..256	CDD:275368	6/20 (30%)
		C2H2 Zn finger	268..288	CDD:275368	5/19 (26%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		zf-H2C2_2	308..332	CDD:290200	6/34 (18%)
		zf-C2H2	322..344	CDD:278523	1/21 (5%)
		C2H2 Zn finger	324..344	CDD:275368	1/19 (5%)
		C2H2 Zn finger	352..368	CDD:275368	7/43 (16%)
ZK546.5	NP_001364799.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100