DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8319 and ZNF560

DIOPT Version :9

Sequence 1:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_689689.2	Gene:	ZNF560 / 147741	HGNCID:	26484	Length:	790	Species:	Homo sapiens

Alignment Length:	444	Identity:	116/444 - (26%)
Similarity:	178/444 - (40%)	Gaps:	97/444 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QVEEYVDGAKLAEMVKTCADV---------QLDPDDAMPQKMCISCVHDARTAYG-----FKRRC 72
            |:....:|.:|.: .|.|.||         .:...:......||....|..:.|.     .|...
Human   203 QLARNQNGEELYD-CKQCEDVFCKHPCLKTNMSTQNRGNTSECIQYAKDLLSLYNKTSTIRKVSV 266

  Fly    73 EENYKKFYLAILNGQVIKDEPNEEDFLFIENPDKGN-------LEAKK------KLNKEIKKTHQ 124
            ...:.|.:..|||.||.:....::.|   |..|.|.       |||.:      ||| |.|:..:
Human   267 FSKHGKSFRLILNVQVQRKCTQDKSF---EGTDYGKAFIYQSYLEAHRKTQSGEKLN-EWKQCGE 327

  Fly   125 TASRTTKSSITTSRAGRQLRSIKNQTFKCELCIKQFKRQINLLDHMKVH--SNSHVCQNCEERFL 187
            ..:.:|..::..     :...||| .::|:.|.|.|:...:|.:||:.|  ...:.|::|.:.|.
Human   328 AFTHSTSHAVNV-----ETHIIKN-PYECKECGKDFRYPTHLNNHMQTHIGIKPYKCKHCGKTFT 386

  Fly   188 FKADLDNHQCYRNSNSTVECPECLKVFSSTQSLDSH-KCKDMQERSPFQCPHCQQAFTREQNLKA 251
            ..:....|...........|.||.|.|.::..|..| :|...::  .|:|.||.:||....:|..
Human   387 VPSGFLEHVRTHTGEKPYGCKECGKAFGTSAGLIEHIRCHAREK--TFKCDHCGKAFISYPSLFG 449

  Fly   252 HLLIH---------------------AESKQGNGPHK---CSYCQTGFFNKSALKVHIHAHMGER 292
            ||.:|                     .|.::.|...|   |..|...|.:.|:|..|:..|.||:
Human   450 HLRVHNGEKPYEHKEYGKAFGTSSGVIEDRRSNTGQKRFDCDQCGKVFVSFSSLFAHLRTHTGEK 514

  Fly   293 PHACPFCVSNFRSKQALKVHIRIHT----------------------------GEKPYQCPHCPK 329
            |..|..|...|.|...|::|:|.||                            |||||:|..|.|
Human   515 PFKCYKCGKPFTSSACLRIHMRTHTEERLYQCKKCGKAFTKCSYLTKHLRTHAGEKPYECMKCGK 579

  Fly   330 TFSDNNNLAKHRRRHSDERPYKCSICLQDFREKHHLKRHFLGKHRDGDQKLKLK 383
            .|::.:.|.||.||||.|:||:|..|.:.|.|:..|.:| |.:| .||:..:.|
Human   580 AFTERSYLTKHLRRHSGEKPYECKKCGKAFTERSDLTKH-LRRH-TGDKPYEYK 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071	12/70 (17%)
		COG5048	<153..368	CDD:227381	76/269 (28%)
		C2H2 Zn finger	153..173	CDD:275368	7/19 (37%)
		C2H2 Zn finger	179..196	CDD:275368	3/16 (19%)
		C2H2 Zn finger	207..227	CDD:275370	8/20 (40%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	308..332	CDD:290200	13/51 (25%)
		zf-C2H2	322..344	CDD:278523	9/21 (43%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		C2H2 Zn finger	352..368	CDD:275368	5/15 (33%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	13..50	CDD:279668
		KRAB	110..161	CDD:214630
		KRAB	110..149	CDD:279668
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..342	CDD:275368	2/23 (9%)
		COG5048	344..754	CDD:227381	85/293 (29%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..386	CDD:290200	6/23 (26%)
		C2H2 Zn finger	378..398	CDD:275368	4/19 (21%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	490..510	CDD:275368	6/19 (32%)
		zf-H2C2_2	502..527	CDD:290200	9/24 (38%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		zf-H2C2_2	531..554	CDD:290200	5/22 (23%)
		C2H2 Zn finger	546..566	CDD:275368	0/19 (0%)
		zf-H2C2_2	558..582	CDD:290200	8/23 (35%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
		zf-H2C2_2	586..610	CDD:290200	12/23 (52%)
		zf-C2H2	600..622	CDD:278523	8/22 (36%)
		C2H2 Zn finger	602..622	CDD:275368	7/20 (35%)
		C2H2 Zn finger	630..650	CDD:275368	1/2 (50%)
		C2H2 Zn finger	658..678	CDD:275368
		C2H2 Zn finger	714..734	CDD:275368
		zf-H2C2_2	726..751	CDD:290200
		C2H2 Zn finger	742..762	CDD:275368
		zf-H2C2_2	757..779	CDD:290200
		C2H2 Zn finger	770..790	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000