Protein Alignment CG8312 and NOS1AP

DIOPT Version :10

• Sequence 1: NP_649918.1
• Gene: CG8312 / 41163
• FlyBaseID: FBgn0037720
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_055512.1
• Gene: NOS1AP / 9722
• HGNCID: 16859
• Length: 506
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 90/466 - (19%)
• Similarity: 156/466 - (33%)
• Gaps: 141/466 - (30%)

  Fly   133 LARLLGNTYN-AKKFEKQEQKRLASGSEGGKFNTYSGRRGRAGPYL---ERFKRVSKEDGDVAGE 193
            :.|.:|..:. ..|...|..::.|.|.|.|:....|...|..|..|   ||....:.|:.|:
Human   157 IVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGRQLTGAERASTATAEETDI--- 218

  Fly   194 DDTVRV----TNVITLTTDSRDLLYGSRQEHVGRTGGYDQNDQLTSKAYRTLTRSLGKLWRRTHS 254
             |.|.|    .:|:..:....||      :.||:.||.....:::......||.|...|
Human   219 -DAVEVPLPGNDVLEFSRGVTDL------DAVGKEGGSHTGSKVSHPQEPMLTASPRML------ 270

  Fly   255 VDISTPDPEFKVSYLGNVLTGWAKAGEGCVEKQLNTLWRNYTQHSKPDVIMRLKVCASGLKATTR 319
                .|....|...||             .|..|:|       |.:..::.:|      |:...:
Human   271 ----LPSSSSKPPGLG-------------TETPLST-------HHQMQLLQQL------LQQQQQ 305

  Fly   320 QHGLTEYWAHRITYCCAPKNYPRVFCWIYRHEGRKLKHELRCHAVLCSKEKIAQDICDTLRENLE 384
            |..:.....|.:....|.:            ...:|:.:.|.|.:|...:.:.|.|...:::..|
Human   306 QTQVAVAQVHLLKDQLAAE------------AAARLEAQARVHQLLLQNKDMLQHISLLVKQVQE 358

  Fly   385 SALREFKREKILKQNARLSL-----ANAVYDNPSLPRRKIMLSVGGNNYRPPLERSKSAPKLMAI 444
            ..|:...:..:..|::.|.:     |..|..:|:.|:.:.:       :.|||
Human   359 LELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDL-------HSPPL------------ 404

  Fly   445 EEAIGEEEGDEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSPCCSSHMAK 509
                    |..:.|...|...|            ||||.|        ..|::.|         :
Human   405 --------GAGLADFAHPAGSP------------LGRRDC--------LVKLECF---------R 432

  Fly   510 ELPQEETKTMAAAGSSANDGSDSDDFEKLLKF-DTTLSNELLPYFDMQLHKNSSQSMVSLSEL-- 571
            .||.|:|.. .|.|.:...|.:      |:|| ::.:::|.....| :..:..|.|...|..|
Human   433 FLPPEDTPP-PAQGEALLGGLE------LIKFRESGIASEYESNTD-ESEERDSWSQEELPRLLN 489

  Fly   572 ---KEEEGEPL 579
               ::|.|:.|
Human   490 VLQRQELGDGL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:405418	29/183 (16%)
NOS1AP	NP_055512.1	PTB_CAPON-like	2..185	CDD:269968	6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..224		14/52 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..260		4/18 (22%)
		PDZ-binding domain	494..506		3/7 (43%)