DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8312 and NUMBL

DIOPT Version :10

Sequence 1:NP_649918.1 Gene:CG8312 / 41163 FlyBaseID:FBgn0037720 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_004747.1 Gene:NUMBL / 9253 HGNCID:8061 Length:609 Species:Homo sapiens


Alignment Length:604 Identity:108/604 - (17%)
Similarity:175/604 - (28%) Gaps:245/604 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 FKVSYLGNVLTGWAKAGEGCVE--KQLNTLWRNYTQHSKPDVIMRLKVCASGLKAT--TRQHGLT 324
            |.|.|||:|....::....|.:  |:|..:.|.       .|...|.|.|.||:..  ..:..|.
Human    80 FPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRK-------SVKSVLWVSADGLRVVDDKTKDLLV 137

  Fly   325 EYWAHRITYCCAPKNYPRVFCWIYR----------------HEGRKLKHELRCHAVLCSKEKIAQ 373
            :....::::|...:|..:.|.:|.|                ..|.:|.|.:.|....|       
Human   138 DQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAAC------- 195

  Fly   374 DICDTLRENLESALREFKREKILKQNARLSLANAVYDNPSLPRRKIMLSVGGNNYRPPLERSKSA 438
                     ||   |:.:|||.....|....:...:....    ...||.||.    |.||  .|
Human   196 ---------LE---RKQRREKECGVTAAFDASRTSFAREG----SFRLSGGGR----PAER--EA 238

  Fly   439 PKLMAIEEAIGEEEGDEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSPCC 503
            |.....|.|                           .|.|:.....:.||        .|.:|..
Human   239 PDKKKAEAA---------------------------AAPTVAPGPAQPGH--------VSPTPAT 268

  Fly   504 SSHMAKELPQE--ETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQLHKNSSQSMV 566
            :|      |.|  |..|..|||::|                ..:.....| .:..:.:.|.:...
Human   269 TS------PGEKGEAGTPVAAGTTA----------------AAIPRRHAP-LEQLVRQGSFRGFP 310

  Fly   567 SLSELKEEEGEPLSLLPTINSDPSADPEADYNAEDHDVTAPRRS-----GVCSDGEEDFLDDADD 626
            :||:........|||  .:|..||              |..||:     |...:.|.....|:| 
Human   311 ALSQKNSPFKRQLSL--RLNELPS--------------TLQRRTDFQVKGTVPEMEPPGAGDSD- 358

  Fly   627 HYFRHAAMLTMLHRSSMRKMRAADQTSLKYRHQTQSSISSNASSSTTASTSAAAGGGSAQQGLTS 691
                                                  |.||..:..:|:.|:||         :
Human   359 --------------------------------------SINALCTQISSSFASAG---------A 376

  Fly   692 PDSDEGSISSGCETASTVTNA-NHEEYNSKRVSDPGQLEQSPDLELEQAQVLEQMMIYQRLEQQL 755
            |       :.|...|:|.|:| ............||. :::|.   |..:.||::....:.:|| 
Human   377 P-------APGPPPATTGTSAWGEPSVPPAAAFQPGH-KRTPS---EAERWLEEVSQVAKAQQQ- 429

  Fly   756 RKNSGDATNYSSSSSITLKRSNSGSDKQERSDHPDDDNSDSDESGYVEFQEKERPGQQPLISEAS 820
                                                           :.|::::..||....:.:
Human   430 -----------------------------------------------QQQQQQQQQQQQQQQQQA 447

  Fly   821 VTLAKIATVKPQVPPKPAP 839
            .::|.:.|:.|.:.|.|||
Human   448 ASVAPVPTMPPALQPFPAP 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8312NP_649918.1 PID_2 263..442 CDD:405418 43/197 (22%)
NUMBLNP_004747.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
PTB_Numb 64..198 CDD:241298 29/143 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..283 22/110 (20%)
NumbF 287..371 CDD:461874 22/155 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..421 15/68 (22%)
PRK12323 <394..584 CDD:481241 18/125 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..464 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..609
Blue background indicates that the domain is not in the aligned region.

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