DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8312 and NUMBL

DIOPT Version :9

Sequence 1:NP_649918.1 Gene:CG8312 / 41163 FlyBaseID:FBgn0037720 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_004747.1 Gene:NUMBL / 9253 HGNCID:8061 Length:609 Species:Homo sapiens


Alignment Length:604 Identity:108/604 - (17%)
Similarity:175/604 - (28%) Gaps:245/604 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 FKVSYLGNVLTGWAKAGEGCVE--KQLNTLWRNYTQHSKPDVIMRLKVCASGLKAT--TRQHGLT 324
            |.|.|||:|....::....|.:  |:|..:.|.       .|...|.|.|.||:..  ..:..|.
Human    80 FPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRK-------SVKSVLWVSADGLRVVDDKTKDLLV 137

  Fly   325 EYWAHRITYCCAPKNYPRVFCWIYR----------------HEGRKLKHELRCHAVLCSKEKIAQ 373
            :....::::|...:|..:.|.:|.|                ..|.:|.|.:.|....|       
Human   138 DQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAAC------- 195

  Fly   374 DICDTLRENLESALREFKREKILKQNARLSLANAVYDNPSLPRRKIMLSVGGNNYRPPLERSKSA 438
                     ||   |:.:|||.....|....:...:....    ...||.||.    |.||  .|
Human   196 ---------LE---RKQRREKECGVTAAFDASRTSFAREG----SFRLSGGGR----PAER--EA 238

  Fly   439 PKLMAIEEAIGEEEGDEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSPCC 503
            |.....|.|                           .|.|:.....:.||        .|.:|..
Human   239 PDKKKAEAA---------------------------AAPTVAPGPAQPGH--------VSPTPAT 268

  Fly   504 SSHMAKELPQE--ETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQLHKNSSQSMV 566
            :|      |.|  |..|..|||::|                ..:.....| .:..:.:.|.:...
Human   269 TS------PGEKGEAGTPVAAGTTA----------------AAIPRRHAP-LEQLVRQGSFRGFP 310

  Fly   567 SLSELKEEEGEPLSLLPTINSDPSADPEADYNAEDHDVTAPRRS-----GVCSDGEEDFLDDADD 626
            :||:........|||  .:|..||              |..||:     |...:.|.....|:| 
Human   311 ALSQKNSPFKRQLSL--RLNELPS--------------TLQRRTDFQVKGTVPEMEPPGAGDSD- 358

  Fly   627 HYFRHAAMLTMLHRSSMRKMRAADQTSLKYRHQTQSSISSNASSSTTASTSAAAGGGSAQQGLTS 691
                                                  |.||..:..:|:.|:||         :
Human   359 --------------------------------------SINALCTQISSSFASAG---------A 376

  Fly   692 PDSDEGSISSGCETASTVTNA-NHEEYNSKRVSDPGQLEQSPDLELEQAQVLEQMMIYQRLEQQL 755
            |       :.|...|:|.|:| ............||. :::|.   |..:.||::....:.:|| 
Human   377 P-------APGPPPATTGTSAWGEPSVPPAAAFQPGH-KRTPS---EAERWLEEVSQVAKAQQQ- 429

  Fly   756 RKNSGDATNYSSSSSITLKRSNSGSDKQERSDHPDDDNSDSDESGYVEFQEKERPGQQPLISEAS 820
                                                           :.|::::..||....:.:
Human   430 -----------------------------------------------QQQQQQQQQQQQQQQQQA 447

  Fly   821 VTLAKIATVKPQVPPKPAP 839
            .::|.:.|:.|.:.|.|||
Human   448 ASVAPVPTMPPALQPFPAP 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8312NP_649918.1 PID_2 263..442 CDD:373244 43/197 (22%)
NUMBLNP_004747.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
PTB_Numb 64..198 CDD:241298 29/143 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..283 22/110 (20%)
NumbF 287..371 CDD:283874 22/155 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..421 15/68 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..464 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..609
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141138
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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