Protein Alignment CG8312 and Dab2

DIOPT Version :10

• Sequence 1: NP_649918.1
• Gene: CG8312 / 41163
• FlyBaseID: FBgn0037720
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_077073.1
• Gene: Dab2 / 79128
• RGDID: 621007
• Length: 768
• Species: Rattus norvegicus
• Alignment Length: 773
• Identity: 145/773 - (18%)
• Similarity: 239/773 - (30%)
• Gaps: 269/773 - (34%)

  Fly   273 LTGWAKAGEGCVEKQLNTLWRNYTQHSKPDVIMRLKVCASGLKATTRQHGLTEYW--AHRITYCC 335
            |.|.|.||            |:..||.:.   :.:.:..||:|....:.|:.|:.  .::|::..
  Rat    76 LKGMAAAG------------RSQGQHKQR---IWVNISLSGIKIIDEKTGVIEHEHPVNKISFIA 125

  Fly   336 APKNYPRVFCWIYRHEGRKLKHELRCHAVLCSKEKIAQDICDTLRENLESALREFKREKILKQNA 400
            ......|.|.::...||   :|:..........|.:..|:.|..:.......:|.:::|:.:
  Rat   126 RDVTDNRAFGYVCGGEG---QHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKVEE--- 184

  Fly   401 RLSLANAVYDNPSL-------PRRKIMLSV------GGNNYRPPLERSKSAPKLMAIEEAIGEEE 452
                ||...:|.|.       ...|:.|.|      |..:..|.|.....:..::.:      :.
  Rat   185 ----ANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNNPTESRDILLV------DL 239

  Fly   453 GDEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSP--CCSSHM-------- 507
            ..|| |||:..:..       .|.:|.|...|    |:.|.....||.|  ..|:::
  Rat   240 NSEI-DTNQNSLRE-------NPFLTNGVTSC----SLPRPKPQASFLPESAFSANLNFFPTPNP 292

  Fly   508 -----------AKELPQEETKTMAAAGSSANDGS------------DSDDFEKLLKFDTTLSNEL 549
                       .:..|.......:|....||.||            |:|.|.:  :|| .:||..
  Rat   293 DPFRDDPFAQPDQSAPSSFHSLTSADQKKANPGSLSTPQSKGPLNGDTDYFGQ--QFD-QISNRT 354

  Fly   550 ---------LPYFDMQLHKNSSQSMVSLSELKEEEGEPL--SLLPTINSDPSA---------DPE 594
                     .||...|. :.:.::...:|| ||:.|..:  |..|.:.|.|..         |.|
  Rat   355 GKQEAQGGPWPYPSSQT-QQAVRTQNGVSE-KEQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLE 417

  Fly   595 ADYNAEDHD---VTAPRRSGVCSDGEEDFLDDADD-----------------------------H 627
            :...:..||   :..|.:|.....|.......|:|                             .
  Rat   418 SSVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFASEPPGQMSPTGQPAVPQANFMD 482

  Fly   628 YFRHAAMLTM-------LHRSSMRKMRAADQTSLKYRHQT------------------------- 660
            .|:.:|...|       |....:...:|...|.:.:...|
  Rat   483 LFKTSAPAPMGSGPLVGLGTVPVTPPQAGPWTPVVFTPSTTVVPGAIISGQPSGFGQPLVFGTTP 547

  Fly   661 -------QSSISSNASSSTTA----STSAAAGGGSAQQGLTSPDSDEGSISSGCETASTVTNANH 714
                   .||.::.||....|    :||.|....|:...|.:|..     ||.....||::..:.
  Rat   548 AVQVWNQPSSFATAASPPPPAVWCPTTSVAPNTWSSTSPLGNPFQ-----SSNIFPPSTISTQSF 607

  Fly   715 EE--YNSKRVSDP------GQLEQS---------PDLELEQAQVLEQMMIYQRLEQQL---RKNS 759
            .:  .:|..|:.|      |.|:.:         |..:.|..:|.|....:|..:..|   ||
  Rat   608 PQPMMSSVLVTPPQPPPRNGPLKDTLSDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLVPSRK-- 670

  Fly   760 GDATNYSSSSSITLKRSNSGSDKQERSDHPDDDNSDSDESGYVEFQEKERPGQQPLISEASVTLA 824
            |:..:..:||:.:...:|.....||..||.|.|                          |:..|.
  Rat   671 GETPSSGTSSAFSSYFNNKVGIPQEHVDHDDFD--------------------------ANQLLN 709

  Fly   825 KIATVKPQVPPKPAPRRSL--------------------SLNAVATGASAGSSAGKAP 862
            ||     ..|||||||:.:                    |.|.......|.|.|.::|
  Rat   710 KI-----NEPPKPAPRQGVLSGTKSADNSLENPFSKGFSSTNPSVVSQPASSDAHRSP 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:405418	34/183 (19%)
Dab2	NP_077073.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		PTB_Dab	35..171	CDD:269926	22/112 (20%)
		Required for localization to clathrin-coated pits. /evidence=ECO:0000250	230..447		47/239 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..449		32/168 (19%)
		DPF 1	293..295		0/1 (0%)
		DPF 2	298..300		0/1 (0%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000250	601..731		35/162 (22%)
		Required for interaction with CSK	619..627		1/7 (14%)
		Required for interaction with MYO6. /evidence=ECO:0000250	649..768		33/147 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..682		6/23 (26%)
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000269|PubMed:12473651	663..671		3/9 (33%)
		Sufficient for interaction with SH3KBP1 SH3 domain. /evidence=ECO:0000250	708..724		10/20 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..768		15/59 (25%)