DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8312 and Dab2

DIOPT Version :9

Sequence 1:NP_649918.1 Gene:CG8312 / 41163 FlyBaseID:FBgn0037720 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_077073.1 Gene:Dab2 / 79128 RGDID:621007 Length:768 Species:Rattus norvegicus


Alignment Length:773 Identity:145/773 - (18%)
Similarity:239/773 - (30%) Gaps:269/773 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 LTGWAKAGEGCVEKQLNTLWRNYTQHSKPDVIMRLKVCASGLKATTRQHGLTEYW--AHRITYCC 335
            |.|.|.||            |:..||.:.   :.:.:..||:|....:.|:.|:.  .::|::..
  Rat    76 LKGMAAAG------------RSQGQHKQR---IWVNISLSGIKIIDEKTGVIEHEHPVNKISFIA 125

  Fly   336 APKNYPRVFCWIYRHEGRKLKHELRCHAVLCSKEKIAQDICDTLRENLESALREFKREKILKQNA 400
            ......|.|.::...||   :|:..........|.:..|:.|..:.......:|.:::|:.:   
  Rat   126 RDVTDNRAFGYVCGGEG---QHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKVEE--- 184

  Fly   401 RLSLANAVYDNPSL-------PRRKIMLSV------GGNNYRPPLERSKSAPKLMAIEEAIGEEE 452
                ||...:|.|.       ...|:.|.|      |..:..|.|.....:..::.:      :.
  Rat   185 ----ANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNNPTESRDILLV------DL 239

  Fly   453 GDEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSP--CCSSHM-------- 507
            ..|| |||:..:..       .|.:|.|...|    |:.|.....||.|  ..|:::        
  Rat   240 NSEI-DTNQNSLRE-------NPFLTNGVTSC----SLPRPKPQASFLPESAFSANLNFFPTPNP 292

  Fly   508 -----------AKELPQEETKTMAAAGSSANDGS------------DSDDFEKLLKFDTTLSNEL 549
                       .:..|.......:|....||.||            |:|.|.:  :|| .:||..
  Rat   293 DPFRDDPFAQPDQSAPSSFHSLTSADQKKANPGSLSTPQSKGPLNGDTDYFGQ--QFD-QISNRT 354

  Fly   550 ---------LPYFDMQLHKNSSQSMVSLSELKEEEGEPL--SLLPTINSDPSA---------DPE 594
                     .||...|. :.:.::...:|| ||:.|..:  |..|.:.|.|..         |.|
  Rat   355 GKQEAQGGPWPYPSSQT-QQAVRTQNGVSE-KEQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLE 417

  Fly   595 ADYNAEDHD---VTAPRRSGVCSDGEEDFLDDADD-----------------------------H 627
            :...:..||   :..|.:|.....|.......|:|                             .
  Rat   418 SSVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFASEPPGQMSPTGQPAVPQANFMD 482

  Fly   628 YFRHAAMLTM-------LHRSSMRKMRAADQTSLKYRHQT------------------------- 660
            .|:.:|...|       |....:...:|...|.:.:...|                         
  Rat   483 LFKTSAPAPMGSGPLVGLGTVPVTPPQAGPWTPVVFTPSTTVVPGAIISGQPSGFGQPLVFGTTP 547

  Fly   661 -------QSSISSNASSSTTA----STSAAAGGGSAQQGLTSPDSDEGSISSGCETASTVTNANH 714
                   .||.::.||....|    :||.|....|:...|.:|..     ||.....||::..:.
  Rat   548 AVQVWNQPSSFATAASPPPPAVWCPTTSVAPNTWSSTSPLGNPFQ-----SSNIFPPSTISTQSF 607

  Fly   715 EE--YNSKRVSDP------GQLEQS---------PDLELEQAQVLEQMMIYQRLEQQL---RKNS 759
            .:  .:|..|:.|      |.|:.:         |..:.|..:|.|....:|..:..|   ||  
  Rat   608 PQPMMSSVLVTPPQPPPRNGPLKDTLSDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLVPSRK-- 670

  Fly   760 GDATNYSSSSSITLKRSNSGSDKQERSDHPDDDNSDSDESGYVEFQEKERPGQQPLISEASVTLA 824
            |:..:..:||:.:...:|.....||..||.|.|                          |:..|.
  Rat   671 GETPSSGTSSAFSSYFNNKVGIPQEHVDHDDFD--------------------------ANQLLN 709

  Fly   825 KIATVKPQVPPKPAPRRSL--------------------SLNAVATGASAGSSAGKAP 862
            ||     ..|||||||:.:                    |.|.......|.|.|.::|
  Rat   710 KI-----NEPPKPAPRQGVLSGTKSADNSLENPFSKGFSSTNPSVVSQPASSDAHRSP 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8312NP_649918.1 PID_2 263..442 CDD:373244 34/183 (19%)
Dab2NP_077073.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
PTB_Dab 35..171 CDD:269926 22/112 (20%)
Required for localization to clathrin-coated pits. /evidence=ECO:0000250 230..447 47/239 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 285..449 32/168 (19%)
DPF 1 293..295 0/1 (0%)
DPF 2 298..300 0/1 (0%)
Sufficient for interaction with GRB2. /evidence=ECO:0000250 601..731 35/162 (22%)
Required for interaction with CSK 619..627 1/7 (14%)
Required for interaction with MYO6. /evidence=ECO:0000250 649..768 33/147 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..682 6/23 (26%)
Required for interaction with GRB2 and CSK. /evidence=ECO:0000269|PubMed:12473651 663..671 3/9 (33%)
Sufficient for interaction with SH3KBP1 SH3 domain. /evidence=ECO:0000250 708..724 10/20 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..768 15/59 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334808
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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