Protein Alignment CG8312 and numb

DIOPT Version :10

• Sequence 1: NP_649918.1
• Gene: CG8312 / 41163
• FlyBaseID: FBgn0037720
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_001035496.1
• Gene: numb / 692064
• ZFINID: ZDB-GENE-060422-1
• Length: 680
• Species: Danio rerio
• Alignment Length: 633
• Identity: 112/633 - (17%)
• Similarity: 195/633 - (30%)
• Gaps: 219/633 - (34%)

  Fly   264 FKVSYLGNVLTGWAKAGEGCVE--KQLNT---LWRNYTQHS-KPDVIMRLKVCASGLKAT--TRQ 320
            |.|.|||:|....::....|.:  |:|.|   :::.:.:.: |..|...|.|.|.||:..  ..:
Zfish    39 FAVRYLGHVEVEESRGMHICEDAVKKLKTDRKVFKGFFKKAGKKAVRAVLWVSADGLRVVDDKTK 103

  Fly   321 HGLTEYWAHRITYCCAPKNYPRVFCWIYR----------------HEGRKLKHELRCHAVLCSKE 369
            ..:.:....::::|...:|:...|.:|.|                ..|.:|.|.:.|....|.:.
Zfish   104 DLILDQTIEKVSFCAPDRNFEHAFSYICRDGTTRRWICHCFMAIKDSGERLSHAVGCAFAACLER 168

  Fly   370 KIAQD----ICDTLREN-----------LESALREFKREKILKQ---NAR-----LSLANAVYDN 411
            |..::    :..|...|           :.:|..:.:||::::|   |.:     :|.::....|
Zfish   169 KQKREKECGVTATFDANRTTFTREGSFRVTTATEQAEREEVMRQLQDNKKDSDLVISSSSGGSCN 233

  Fly   412 PSLPRRKIMLSVGGNNYRPPLERSKSAPKLMAIEEAIGEEEGDEIEDTNEPEMMPCCQKDSLYPA 476
            |      :::::.|.|      .|.|.|..||   .:|.::|:       |.::|
Zfish   234 P------VVVTLAGPN------GSSSPPLPMA---PLGLQDGN-------PHVIP---------- 266

  Fly   477 MTLGRRRCRRGHSIRRTGKIQSFSPCCS----------SHMAKELPQEETKTMAAAGSSANDGSD 531
                 ||.....::.|.|..:.| |..|          |....|||    .||..
Zfish   267 -----RRHAPVEALARQGSFRGF-PALSQKTSPFKRQMSLRMNELP----STMQR---------- 311

  Fly   532 SDDFEKLLKFDTTLSNELLPYFDMQLHKNSSQSMVSLSELKEEEGEPLSLLPTINSDPSADPEAD 596
                    |.|..:.| .:|..:.::...||......|.......:|.|..|.  ..|::.|::.
Zfish   312 --------KSDFPIKN-TVPEVEGEVDSISSLCTQITSTFSGPPEDPFSSAPM--PKPASSPQSP 365

  Fly   597 YNAEDHDVTAPRRSGVCSDGEEDFLDDADDHYFRHAAMLTMLHRSSMRKMRAADQTSLKYRHQTQ 661
                    .||....|                       ......|:....||:...|.......
Zfish   366 --------AAPVNGAV-----------------------PAFPPPSVTVTTAANSPVLPPPPLPV 399

  Fly   662 SSISSNASSSTTASTSAAAGGGSAQQGLTSPDSDEGSISSGCETASTVTNANHEEYNSKRVSDPG 726
            ...:..|.:..||...||..|..    ..||....|::.:...|.||..:|:
Zfish   400 RETNPWAKAPNTAPAHAAHTGSE----WPSPSPSTGALPAVSATLSTPASAH------------- 447

  Fly   727 QLEQSPDLELEQAQVLEQMMIYQRLEQQLRKNSGDATNYSSSSSITLKRSNSGSDKQERSDHPDD 791
              :::|.   |..:.||::                                   .|..|:..|..
Zfish   448 --KRTPS---EADRWLEEV-----------------------------------TKSVRAHQPAP 472

  Fly   792 DNSDSDESGYVEFQEKERPGQQPLISEASVTLAKIATVKPQVPPKPAP 839
            ....|..           |.|||..:...|.:...|...|.:||...|
Zfish   473 TARTSTP-----------PAQQPFPAPVPVPMPPSAPFMPPIPPSAVP 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:405418	43/224 (19%)
numb	NP_001035496.1	PTB_Numb	23..168	CDD:241298	27/128 (21%)
		NumbF	262..342	CDD:461874	22/118 (19%)
		PHA03247	<345..667	CDD:223021	43/266 (16%)