DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8312 and dab1b

DIOPT Version :9

Sequence 1:	NP_649918.1	Gene:	CG8312 / 41163	FlyBaseID:	FBgn0037720	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_005171167.1	Gene:	dab1b / 678641	ZFINID:	ZDB-GENE-060421-7958	Length:	520	Species:	Danio rerio

Alignment Length:	509	Identity:	95/509 - (18%)
Similarity:	174/509 - (34%)	Gaps:	157/509 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LKVCASGLKATTRQHGLTEYW--AHRITYCCAPKNYPRVFCWIYRHEGRKLKHELRCHAVLCSKE 369
            |.|...|:|....:.|:.::.  .|.|:|........|.|.::.   |:|..|:........:..
Zfish    96 LTVSFGGIKIYDERSGVLQHHHSVHEISYIAKDSRDHRAFGYVC---GKKGNHKFVAIKTSHAAA 157

  Fly   370 KIAQDICD--TLRENL---ESALREFKREKILKQNARLSLANAVYDNPSLPRRKIMLSVGGNNYR 429
            .:..|:.|  ||..::   |.|.::.::||..:|....::.....|:|..  :.|:...|    .
Zfish   158 PVILDLRDLFTLIHDIKQREEAEKKSQKEKHCEQVIYQTILEDEVDDPVY--QYIVFEAG----H 216

  Fly   430 PPLERSKSAPKLMAIEEAIGE----EEGDEIEDTNEPEMMPCCQKDSLY---------------P 475
            .||...:|       ||::.:    ::.|.|.|..:..:|....:..|:               |
Zfish   217 EPLHGHQS-------EESVYQVPTSQQKDGIYDVPKHHLMANISQVDLFGDMATPPDILSMPASP 274

  Fly   476 AMTL--GRRRCRRGHSIR-----------------RTGKIQ-----------SFSPCCSSHMAKE 510
            |.||  ||||    ..:|                 ..|.:|           :|......|||:.
Zfish   275 ATTLDPGRRR----RFVRPELFTHFSPPAVPTGYMTMGALQAAHWTPQATPMAFGVQTPLHMAQM 335

  Fly   511 LPQEETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQL--HKNSS---QSMVSLSE 570
            ||..:......|....:..:....:            ..:|...:.|  |..|:   |.::.|:.
Zfish   336 LPGGQPVIWGQANLFHSPATGQQQW------------AFVPAQAVGLGTHPISAAVLQGLIPLAS 388

  Fly   571 LKEEEGEPLSLLPTINSD--------PSADPEADYNAEDHD--VTAPRRSGVCSDGEEDFLDDAD 625
            ::.:..||    |..:|:        .|...|...|.:.|:  :||.    :|.: ::|.::.:.
Zfish   389 MRPQSCEP----PETSSNFMSPQHLVDSRGSEHAINTDPHEEVITAE----ICIN-KQDTIEPSV 444

  Fly   626 DHYFRHAAMLTMLHRSSMRKMRAADQTSLKYRHQTQSSISSNASSSTTASTSAAAGGGSAQQGLT 690
            |               |..::                .:|.....:|..||||     ||.....
Zfish   445 D---------------SCEEL----------------DLSQMTLQTTEPSTSA-----SATDSCA 473

  Fly   691 SPDSDEGSISSGCETASTVTNANHEEYNSKRVSDPGQLEQSPDLELEQAQVLEQ 744
            :||.::       :|.:..|:.  ||.....||.|..||::.|.::......:|
Zfish   474 TPDPEK-------QTTADATSV--EELQDSSVSVPEVLEKAADAQINPPDSSQQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:373244	29/141 (21%)
dab1b	XP_005171167.1	PTB_Dab	34..182	CDD:269926	19/88 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574040
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840