DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8312 and Ldlrap1

DIOPT Version :9

Sequence 1:	NP_649918.1	Gene:	CG8312 / 41163	FlyBaseID:	FBgn0037720	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001102741.1	Gene:	Ldlrap1 / 500564	RGDID:	1563417	Length:	307	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	59/220 - (26%)
Similarity:	91/220 - (41%)	Gaps:	47/220 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 RSLGKLWRRTHSVDISTPDPEFKVSYLGNVLTGWAKAGE---GCVEKQLNTLWRNYTQHSKPDVI 304
            |.|.:.|..|....:.  ...|.:.|||..|....|..|   ..|::.:.|...:..:..|
  Rat    28 RKLPENWTDTRETLLE--GMVFSLKYLGMTLVERPKGEELSAAAVKRIVATAKASGKKLQK---- 86

  Fly   305 MRLKVCASGLKAT---TRQHGLTEYWA-HRITYCCAPKNYPRVFCWIYRHEGRKLKHELRCHAVL 365
            :.|||...|:..|   |.|  |.|..: :||:||.|.|.:.:||.:|.:.:..:   .|.|||.|
  Rat    87 VTLKVSPRGIILTDSLTSQ--LIENVSIYRISYCTADKMHDKVFAYIAQSQQNE---SLECHAFL 146

  Fly   366 CSKEKIAQDICDTLRENLESALREF---------KREKILKQNARLSLANAVYDNPSLPRRKIML 421
            |:|.|:||.:..|:.:..:.|. ||         ||||..::..         |.|...|
  Rat   147 CTKRKVAQAVTLTVAQAFKVAF-EFWQVSKEEKEKREKANQEGG---------DVPGTRR----- 196

  Fly   422 SVGGNNYRPPLERSKSAPKLMAIEE 446
                 :..|.|:.|.:...|:.:||
  Rat   197 -----DSTPSLKTSVATGNLLDLEE 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:373244	52/194 (27%)
Ldlrap1	NP_001102741.1	PTB_LDLRAP-mammal-like	43..165	CDD:269981	39/132 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..205		9/44 (20%)
		Clathrin box. /evidence=ECO:0000250\|UniProtKB:Q5SW96	211..215		1/3 (33%)
		AP-2 complex binding. /evidence=ECO:0000250\|UniProtKB:Q5SW96	248..275
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250\|UniProtKB:Q5SW96	256..265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840