DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8312 and fam43b

DIOPT Version :9

Sequence 1:	NP_649918.1	Gene:	CG8312 / 41163	FlyBaseID:	FBgn0037720	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001004547.1	Gene:	fam43b / 447808	ZFINID:	ZDB-GENE-040912-11	Length:	303	Species:	Danio rerio

Alignment Length:	238	Identity:	78/238 - (32%)
Similarity:	123/238 - (51%)	Gaps:	34/238 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LGKLWR-RTHSVDISTPDPEFKVSYLGNVLTGWAKAGEGCVEKQLNTLW--RNYTQHSKPDVI-- 304
            ||.::. :...|:::..:|.:.|.|||:.:|..|| ||.|.::.:..:|  .||.:.|....|
Zfish    52 LGSVFHSKRQKVELNKEEPTYNVRYLGSAVTIVAK-GEDCTQEAVAKIWTRSNYGEQSAKMKITV 115

  Fly   305 ----MRLKVCASGLKATTRQHGLTEYWAHRITYCCAPKNYPRVFCWIYRHEGRKLKHELRCHAVL 365
                :|:.|..||.|..:....|     :|||||.|....|::..|||||:.:.....|||||||
Zfish   116 GPHGIRMGVDKSGKKKPSHLFSL-----NRITYCTADPFRPKILAWIYRHQVKNKAVVLRCHAVL 175

  Fly   366 CSKEKIAQDICDTLRENLESALREFKREKILKQNA------RLSLANAVYDNPSLPRRKIMLSVG 424
            .:|.:.|:.:..:|.:|..||..||||   ||:.:      :..|...:.  |.:|.|:::  .|
Zfish   176 LAKAEKARALALSLYQNTTSAFTEFKR---LKRQSDFRHCQQQLLGEDIV--PLMPLRRLL--NG 233

  Fly   425 GNNYRPPLERSKSAPKLMAIEEAIGEEEGDEI---EDTN-EPE 463
            ..:|:||.|:..||.:|.:|.|.  ||:.||:   :.|| .||
Zfish   234 QCHYQPPAEKPGSATRLSSITEE--EEDEDELGGAQSTNTSPE 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:373244	63/192 (33%)
fam43b	NP_001004547.1	PH-like	71..254	CDD:302622	64/195 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574031
Domainoid	1	1.000	105	1.000	Domainoid score	I6582
eggNOG	1	0.900	-	-		E1_KOG4448
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003422
OrthoInspector	1	1.000	-	-		otm25286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5446
SonicParanoid	1	1.000	-	-		X2312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870