DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8312 and Dab

DIOPT Version :9

Sequence 1:	NP_649918.1	Gene:	CG8312 / 41163	FlyBaseID:	FBgn0037720	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster

Alignment Length:	1042	Identity:	188/1042 - (18%)
Similarity:	322/1042 - (30%)	Gaps:	400/1042 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SVSQAVINTKVAAAAATAAAATPNNEPNSNTLKKAKERRT----LFHFG---------------- 83
            ::|...::::...:.||::||.....|..:|..:..:..|    |...|
  Fly  1331 AISNLSLDSRDRVSPATSSAAPSRGAPGLHTPSQFNDVSTSPIPLQKPGMGPSPVPSQLSAVSQL 1395

  Fly    84 ---SNKKLSQSKSQESQEAGSKDATPATTAAPL---PPVPIGTPPRQHKFVKS--NSLARLLGNT 140
               :.|::...|.:|.|...:.|:..|...|.|   ||.|..:...|...|:|  :|..|..|.:
  Fly  1396 IDTATKQMMGDKDREKQSWATFDSPKAKGKARLTLPPPPPPASNTSQPDTVESPCSSDPRDDGWS 1460

  Fly   141 YNAKKFEKQEQKRLASGSE-----GGKFNTYSGRR----------------------GRAGPYLE 178
            ...:::.|:|:::.:|.|.     ..:...|..||                      .|.|.|:.
  Fly  1461 KQQRRWAKKERQQTSSSSRDLSPWDDETPEYLKRRQLAAAQMAHPHQPPMQAPPQHTDRHGYYMR 1525

  Fly   179 RFKRVSK--EDGDVAGEDDTVRVTNVITLTTDSRDLLYGSRQEHVGRTGGYDQNDQLTSKAYRTL 241
            ..:|::.  ||.|..||                    :.:|::.       .|:.|...|....|
  Fly  1526 HARRMNSCDEDYDYDGE--------------------FVARRDQ-------PQHQQQQRKFKHGL 1563

  Fly   242 TRSLGKLWRRTHSVDISTPDPEFKVSYLGNVLTGWAKAGEGCVEKQLNTLWRNYTQHS--KPDVI 304
            :||       ..:.::.:|.                              |.::..|.  .|..|
  Fly  1564 SRS-------RDNFELESPS------------------------------WYHHPAHHTWSPQEI 1591

  Fly   305 MRLKVCASGLKATTRQHGLTEYWAHRITYCCAPKNYPR--VFCWIYRHEGRKLKHELRCHAVLCS 367
            .:::|         |....|.|  .|.:|...|..|.:  .....||.:.|..:.|.       .
  Fly  1592 EQVRV---------RSFDRTAY--ERSSYGPPPPIYDKRGQLRGKYRGDHRDRERER-------D 1638

  Fly   368 KEKIAQDIC----DTLRENL------ESAL----------------REFKREKILKQNARLSLAN 406
            :::..:|..    |...||:      .|.|                |:..||:..|...|.||.:
  Fly  1639 RDREYRDYARPSYDFDYENVYEERGGRSPLAYKPGRGGGDYLYDRERDRDRERDRKSFDRESLES 1703

  Fly   407 AVYDNPSLPRRKIMLSVGGNN-----------YRPPLERSKSAPK----------------LMAI 444
              |::.:..||    |.|..|           ||...||.:...:                .:.|
  Fly  1704 --YESATRRRR----SFGSGNDVYGSLDSRDDYRGDRERDRERDREQMKTRSLRKPTTTSGKLRI 1762

  Fly   445 EEAIGEEEGDEIEDTNEPEMMPCCQK------DSLYPA-MTLGRRRCRR--------GHSIRRTG 494
            ...|..|:..| :|..:...:...|:      |.:.|: ..:|.:|.|:        |......|
  Fly  1763 SGDIDYEQDSE-QDFQQRSGVRSLQRPNQLGGDVVLPSNAVVGPQRLRKSSGSSPWDGEEPALPG 1826

  Fly   495 KIQSFSPCCSSHMAKELPQEETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQLHK 559
            :.....|..::...:.|  .|::...|.|.:.:||.....|.|                     |
  Fly  1827 QKSWKRPASAAETERRL--AESRRAVALGQTPSDGEKERRFRK---------------------K 1868

  Fly   560 NSSQSMVSLSELKEEEGEPLSLLPTINSDPSADPEADYN---AEDHDVTAP-RRSGVCSDGEEDF 620
            ..::|...|:.:    |.|       ::..||...:.|.   .:::|...| :|:....|.:||:
  Fly  1869 TRARSAKDLATV----GAP-------SASTSAPSRSSYGRGIRDNYDYICPGQRNDDDDDDDEDY 1922

  Fly   621 LDD---ADDHYF------RHAAMLTML--HRSSMRKMRAADQTSLKYRHQTQSSIS--------- 665
            :||   .|:..|      ||.....||  .|..|.:.:......|..:::|:..::
  Fly  1923 VDDEPPTDEDKFERLNRRRHEMHQRMLESERRQMERHQPPSLAKLPGQNRTRGVVANSDYGFVDS 1987

  Fly   666 ----------SNASSSTTASTSAAAGGGSAQQGLTS------------------PDSDEGSISSG 702
                      |||||  |........||.:..|:||                  |.:..|:.||.
  Fly  1988 YEQTPTPTPRSNASS--TGPGGLMMSGGESSAGVTSSKFNFDDGFESDFNQSSPPPAPAGTASSC 2050

  Fly   703 CETASTVTNANHEEYNSKRV-------SDPGQLEQ------------------------------ 730
            ..|.:...:||.....||.:       ||..:.||
  Fly  2051 NSTPAGPVSANANNGGSKSLFRFSNDFSDREKREQFEMDTPPTSTPPITQKLRFDDNVKVSQFDD 2115

  Fly   731 ----------SPDLELEQA----------------QVLEQMMIYQRLEQQLRKNSGDATNYSSSS 769
                      |.|.|.|||                |.:....:.||  |:|.|.       |.|.
  Fly  2116 AAFEDDFAKASFDFEKEQAGSATAGAGGSGAMSRKQNMRTSKLQQR--QELIKK-------SESV 2171

  Fly   770 SITLKRSN---------SGSDKQERSDHPDDDNSD-----SDESGYVEFQEK--------ERPGQ 812
            :|..|:..         ...|:::..|..:||...     |:::.:.:|.|.        :..||
  Fly  2172 NIFAKKQEDPFEDDEFFKSPDQEQAMDQHNDDTEGGKFQWSEDANFAKFDENMXFDQLFAKASGQ 2236

  Fly   813 QP 814
            :|
  Fly  2237 RP 2238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:373244	39/235 (17%)
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11232
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030