Protein Alignment CG8312 and numb

DIOPT Version :10

• Sequence 1: NP_649918.1
• Gene: CG8312 / 41163
• FlyBaseID: FBgn0037720
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_523523.2
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 738
• Identity: 141/738 - (19%)
• Similarity: 229/738 - (31%)
• Gaps: 213/738 - (28%)

  Fly   137 LGNTYNAKKFEKQEQKRLASGSEGGKFNTYSGRRGRAGPYLERFKRVSKEDGDVAGEDDTVRVTN 201
            :||:      .....:.|..|...|||...  :.|::..:  ||.:.|.:..|
  Fly     1 MGNS------SSHTHEPLERGFTRGKFGDV--KNGKSASF--RFSKKSPKKMD------------ 43

  Fly   202 VITLTTDSRDLLYGSRQEHVGRTGGYDQNDQLTSKAYRTLTRSLGKLWRRTHSVDISTPDPEFKV 266
              .|....|| .:..|::.|..:....| .|...:|.|:.|.|                   |.|
  Fly    44 --RLRRSFRD-SFRRRKDRVPESSKPHQ-WQADEEAVRSATCS-------------------FSV 85

  Fly   267 SYLGNVLTGWAKAGEGCVEKQLNTLWRNYTQHSKPDVIMRLKVCASGLKATTRQ-HGL-TEYWAH 329
            .|||.|....::..:.| |:.|..|    .|..:..|...|.|...||:....: .|| .:....
  Fly    86 KYLGCVEVFESRGMQVC-EEALKVL----RQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIE 145

  Fly   330 RITYCCAPKNYPRVFCWIYR----------------HEGRKLKHELRCHAVLCSKEKIAQDICDT 378
            ::::|...:|:.|.|.:|.|                ..|.:|.|.:.|...:|.:.|..:|....
  Fly   146 KVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECG 210

  Fly   379 LRENLESALREFKREKILKQNARLSLANAVYDNPSLPRRKIMLSVGGNNYRPPLERSKSAPKLMA 443
            :....::....|.|....:|.             :|..|..|.:||.|      |||...|
  Fly   211 VTMTFDTKNSTFTRTGSFRQQ-------------TLTERLAMATVGTN------ERSVDGP---- 252

  Fly   444 IEEAIGEEEGDEIEDTN-----EPEMMP-CCQKDSLYPAMTLGRRR-CRRGHSIRRTGKIQSFSP 501
             ..|:.......::..|     .|...| ..::.|.:...|:|.:. .:|..|:|
  Fly   253 -GSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLR---------- 306

  Fly   502 CCSSHMAKELPQEETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQLHKNSSQSMV 566
                  ..:||....:..|...::|.:                         .||....|...:.
  Fly   307 ------INDLPSNADRQRAFLTAAAGN-------------------------PMQTPLRSVSPIA 340

  Fly   567 SLSELKEEEGEPLSLLPTINSDPSADPEADYNAEDHDVTAPRRSGVCSDGEE--DFLDDADDHYF 629
            .:|..|....:|||...                    |.|...|.:|.:..:  ..|...|
  Fly   341 EVSPAKSAGADPLSAAA--------------------VAADSVSQLCQELSQGLSLLTQTD---- 381

  Fly   630 RHAAMLTMLHRSSMRKMRAADQTSLKYRHQTQSSISSNASSSTTASTSAAAGGGSAQQGL--TSP 692
               |:|......:....|:.:|..:....|.| .:.|.| ..|...|...|......|.|  .||
  Fly   382 ---ALLAAGEDLNFNNNRSINQNIIAAEKQVQ-HVHSYA-PPTAQVTPRVASTTPTYQTLHSQSP 441

  Fly   693 DSDEGSISSGCETASTVTNANHEEYNSKRVSDPGQLEQSPDLELEQAQVLEQMMIYQRLEQQLRK 757
            ...|.||    ||::.:.||.....:..|.:.|...::...|                      .
  Fly   442 SRSEQSI----ETSTELPNAEQWLGHVVRSTSPAAPKRPTYL----------------------A 480

  Fly   758 NSGDATNYSSSSSITLKRSNSGSDKQERSDHPDDDNSDSDESGYVEFQEKERPGQQPLISEASVT 822
            |.|.|...:|.:...:   ..|.         .||..|::....|...::..| ..|:.|.|...
  Fly   481 NVGRAQTLASGTGAAV---GGGG---------PDDPFDAEWVANVAAAKQLSP-DLPIPSTARSP 532

  Fly   823 LAKIATVKPQVPPKPAPRRSLSL 845
            ||:.:| .|.:.|..||.:|..:
  Fly   533 LARHST-NPFISPPKAPAQSFQV 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:405418	44/196 (22%)
numb	NP_523523.2	PTB_Numb	67..201	CDD:241298	35/158 (22%)
		NumbF	269..374	CDD:461874	24/165 (15%)