Protein Alignment CG8312 and Numbl

DIOPT Version :10

• Sequence 1: NP_649918.1
• Gene: CG8312 / 41163
• FlyBaseID: FBgn0037720
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: XP_006228627.1
• Gene: Numbl / 292732
• RGDID: 1307579
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 101/528 - (19%)
• Similarity: 164/528 - (31%)
• Gaps: 185/528 - (35%)

  Fly   264 FKVSYLGNVLTGWAKAGEGCVE--KQLNTLWRNYTQHSKPDVIMRLKVCASGLKAT--TRQHGLT 324
            |.|.|||:|....::....|.:  |:|..:.|.       .|...|.|.|.||:..  ..:..|.
  Rat   107 FPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRK-------SVKSVLWVSADGLRVVDDKTKDLLV 164

  Fly   325 EYWAHRITYCCAPKNYPRVFCWIYR----------------HEGRKLKHELRCHAVLCSKEKIAQ 373
            :....::::|...:|..:.|.:|.|                ..|.:|.|.:.|....|
  Rat   165 DQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAAC------- 222

  Fly   374 DICDTLRENLESALREFKREKILKQNARLSLANAVYDNPSLPRRKIMLSVGGNNYRPPLERSKSA 438
                     ||   |:.:|||.....|....:...:....    ...||.||.    |.||
  Rat   223 ---------LE---RKQRREKECGVTAAFDASRTSFAREG----SFRLSGGGR----PAER---- 263

  Fly   439 PKLMAIEEAIGEEEGD--EIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSP 501
                        |.||  :.|....|.:.|       .||        :.||        .|.:|
  Rat   264 ------------EAGDKKKAEAAAAPAVAP-------GPA--------QPGH--------VSPTP 293

  Fly   502 CCSSHMAKELPQE--ETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQLHKNSSQS 564
            ..:|      |.|  |..|..|||::|                ..:.....| .:..:.:.|.:.
  Rat   294 ATTS------PGEKGEAGTPVAAGTTA----------------AAIPRRHAP-LEQLVRQGSFRG 335

  Fly   565 MVSLSELKEEEGEPLSLLPTINSDPSADPEADYNAEDHDVTAPRRS-----GVCSDGEEDFLDDA 624
            ..:||:........|||  .:|..||              |..||:     |...:.|.....|:
  Rat   336 FPALSQKNSPFKRQLSL--RLNELPS--------------TLQRRTDFQVKGTVPEMEPPGTGDS 384

  Fly   625 DDHYFRHAAMLTMLHRSSMRKMRAADQTSLKYRHQTQSSISSNASSSTTASTSAAAGGGSAQQGL 689
            |.                                  .|::.:..|||..::.:...|..||..|.
  Rat   385 DG----------------------------------ISALCTQISSSFASAGAPVPGPPSATTGT 415

  Fly   690 TSPDSDEGSISSGCETASTVTNANHEEYNSKR---VSDPGQLEQSPDLELEQAQVLEQMMIYQRL 751
            ::  ..|.|:     .|:|.....|:...|:.   :.:..|:.::...:.:|.|..:|....|:.
  Rat   416 SA--WGEPSV-----PAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQ 473

  Fly   752 EQQLRKNS 759
            :||.:..|
  Rat   474 QQQQQATS 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:405418	41/197 (21%)
Numbl	XP_006228627.1	PTB_Numb	91..225	CDD:241298	29/143 (20%)
		PHA03247	<286..627	CDD:223021	52/284 (18%)
		NumbF	314..398	CDD:461874	21/150 (14%)