DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8312 and LDLRAP1

DIOPT Version :9

Sequence 1:NP_649918.1 Gene:CG8312 / 41163 FlyBaseID:FBgn0037720 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_056442.2 Gene:LDLRAP1 / 26119 HGNCID:18640 Length:308 Species:Homo sapiens


Alignment Length:193 Identity:55/193 - (28%)
Similarity:87/193 - (45%) Gaps:35/193 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 FKVSYLGNVLTGWAKAGE---GCVEKQLNTLWRNYTQHSKPDVIMRLKVCASGLKAT---TRQHG 322
            |.:.|||..|....|..|   ..:::.:.|...:..:..|    :.|||...|:..|   |.|  
Human    48 FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQK----VTLKVSPRGIILTDNLTNQ-- 106

  Fly   323 LTEYWA-HRITYCCAPKNYPRVFCWIYRHEGRKLKHELRCHAVLCSKEKIAQDICDTLRENLESA 386
            |.|..: :||:||.|.|.:.:||.:|.:.:..:   .|.|||.||:|.|:||.:..|:.:..:.|
Human   107 LIENVSIYRISYCTADKMHDKVFAYIAQSQHNQ---SLECHAFLCTKRKMAQAVTLTVAQAFKVA 168

  Fly   387 LREF---------KREKILKQNARLSLANAVYD-NPSLPRRKIMLSVGGNNYRPPLERSKSAP 439
            . ||         ||:|..::..  .:..|..| .|||   |.:::.|.   ...||.:..||
Human   169 F-EFWQVSKEEKEKRDKASQEGG--DVLGARQDCTPSL---KSLVATGN---LLDLEETAKAP 222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8312NP_649918.1 PID_2 263..442 CDD:373244 55/193 (28%)
LDLRAP1NP_056442.2 PTB_LDLRAP-mammal-like 44..166 CDD:269981 38/126 (30%)
Clathrin box. /evidence=ECO:0000269|PubMed:12221107 212..216 0/3 (0%)
AP-2 complex binding. /evidence=ECO:0000269|PubMed:12221107 249..276
[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000269|PubMed:16516836 257..266
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141146
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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