DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8312 and FAM43A

DIOPT Version :9

Sequence 1:	NP_649918.1	Gene:	CG8312 / 41163	FlyBaseID:	FBgn0037720	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_710157.2	Gene:	FAM43A / 131583	HGNCID:	26888	Length:	423	Species:	Homo sapiens

Alignment Length:	512	Identity:	141/512 - (27%)
Similarity:	218/512 - (42%)	Gaps:	137/512 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 DLLYGSRQEHVGRTGGYDQNDQLTSKAYRTLTRS--------LGKLWR-RTHSVDISTPDPEFKV 266
            :||..:......:..||..:  |...|..:|.|:        :|.::| :...:.|::.||.:.|
Human    10 ELLAEAPPRQASKPKGYAVS--LHYSALSSLARACPEGALSRVGSMFRSKRKKLHITSEDPTYTV 72

  Fly   267 SYLGNVLTGWAKAGEGCVEKQLNTLWRNYTQHSKPDVIMRLKVCASGL-------KATTRQHGLT 324
            .||||..|..|: |:||.:..:..:| :.::..:....|:|.|.|.|:       :|..|...|
Human    73 LYLGNATTIQAR-GDGCTDLAVGKIW-SKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHL- 134

  Fly   325 EYWAHRITYCCAPKNYPRVFCWIYRHEGRKLKHE---LRCHAVLCSKEKIAQDICDTLRENLESA 386
             |..||:|||.|....|:||.|:||||   |||:   |||||||.||.:.||.:...|.:...:|
Human   135 -YLLHRVTYCVADARLPKVFAWVYRHE---LKHKAVMLRCHAVLVSKPEKAQAMALLLYQTSANA 195

  Fly   387 LREFKREKILKQNARLSLANAV--YDNPSLPRRKIMLSVGGNNYRPPLERSKSAPKLMAI-EEAI 448
            |.||||.| .:.:||......|  :..|.:|.||::|. |...|:||:|||:|||||.:| |:.:
Human   196 LAEFKRLK-RRDDARHQQQELVGAHTIPLVPLRKLLLH-GPCCYKPPVERSRSAPKLGSITEDLL 258

  Fly   449 GEEEGDEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSPCCSSHMAKELPQ 513
            ||:...|:::..|.|....|                                           |:
Human   259 GEQLEQELQEEEEEEQPEGC-------------------------------------------PE 280

  Fly   514 EETKTMAAAGSSANDGSDSDDFEKLLKFDTTLSNELLPYFDMQLHKNSSQSMVSLSELKEEEGEP 578
            || :..||.|..|.:.:::   ::.|.              :.:|.....   .|..|:...||.
Human   281 EE-ENRAAEGDPAEEEAEA---QRALV--------------VAMHFECGD---LLDTLENGRGEA 324

  Fly   579 L-----SLLPTINSDP----SADPEADYNAEDHDVTAPRRSGVCSD-GEEDFLDDADDHYFRHAA 633
            |     ||.|.....|    ||   :|..||        .|.:.|| ||..|.:|
Human   325 LGGGGGSLGPGAGPPPLLLGSA---SDMKAE--------LSQLISDLGELSFGND---------- 368

  Fly   634 MLTMLHRSSMRKMRAADQTSLKYRHQTQSSISS---NASSSTTASTSAAAGGGSAQQ 687
            :.|:.....:.::.:.|.|.      ::|||..   :|:|:|...:|..|.|.||.:
Human   369 VRTLQADLRVTRLLSGDSTG------SESSIEGGGPDATSATAGDSSRQADGASADE 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:373244	75/190 (39%)
FAM43A	NP_710157.2	PID_2	69..256	CDD:317162	77/195 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..298		11/78 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..344		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..423		13/44 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141147
Domainoid	1	1.000	111	1.000	Domainoid score	I6245
eggNOG	1	0.900	-	-		E1_KOG4448
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003422
OrthoInspector	1	1.000	-	-		otm40360
orthoMCL	1	0.900	-	-		OOG6_109265
Panther	1	1.100	-	-	LDO	PTHR11232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5446
SonicParanoid	1	1.000	-	-		X2312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770