DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8312 and Dab2

DIOPT Version :9

Sequence 1:	NP_649918.1	Gene:	CG8312 / 41163	FlyBaseID:	FBgn0037720	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_075607.2	Gene:	Dab2 / 13132	MGIID:	109175	Length:	766	Species:	Mus musculus

Alignment Length:	761	Identity:	143/761 - (18%)
Similarity:	232/761 - (30%)	Gaps:	269/761 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 LTGWAKAGEGCVEKQLNTLWRNYTQHSKPDVIMRLKVCASGLKATTRQHGLTEYW--AHRITYCC 335
            |.|.|.||            |:..||.:.   :.:.:..||:|....:.|:.|:.  .::|::..
Mouse    76 LKGMAAAG------------RSQGQHKQR---IWVNISLSGIKIIDEKTGVIEHEHPVNKISFIA 125

  Fly   336 APKNYPRVFCWIYRHEGRKLKHELRCHAVLCSKEKIAQDICDTLRENLESALREFKREKILKQNA 400
            ......|.|.::...||   :|:..........|.:..|:.|..:.......:|..::|:.:
Mouse   126 RDVTDNRAFGYVCGGEG---QHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEDKKKVEE--- 184

  Fly   401 RLSLANAVYDNPSL-------PRRKIMLSVG-----GNNYRPPLERSKSAPKLMAIEEAIGEEEG 453
                ||...:|.|.       ...|:.|.|.     |:...||...|.:..|.:.:.:.     .
Mouse   185 ----ANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNSPTESKDILLVDL-----N 240

  Fly   454 DEIEDTNEPEMMPCCQKDSLYPAMTLGRRRCRRGHSIRRTGKIQSFSP----------------- 501
            .|| |||:..:..       .|.:|.|...|    |:.|.....||.|
Mouse   241 SEI-DTNQNSLRE-------NPFLTNGVTSC----SLPRPKPQASFLPENAFSANLNFFPTPNPD 293

  Fly   502 -------------CCSSHMAKELPQEETKTMAAAGSSANDG---SDSDDFEKLLKFDTTLSNEL- 549
                         ..||..:...|.::..:::::.:..:.|   .|:|.|.:  :|| .|||..
Mouse   294 PFRDDPFAQPDQSAPSSFDSLTSPDQKKASLSSSSTPQSKGPLNGDTDYFGQ--QFD-QLSNRTG 355

  Fly   550 --------LPYFDMQLHKNSSQSMVSLSELKEEEGEPL--SLLPTINSDPSA---------DPEA 595
                    .||...|. :.:.::...:|| :|:.|..:  |..|.:.|.|..         |.|:
Mouse   356 KPEAQGGPWPYPSSQT-QQAVRTQNGVSE-REQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLES 418

  Fly   596 DYNAEDHD---------VTAPRR----------------------------SGVCSDGEEDFLDD 623
            ...:..||         .|.|.|                            :|..:..:.:|||.
Mouse   419 SVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFASEPPGQMSPTGQPAVPQSNFLDL 483

  Fly   624 ADDHYFRHAAMLTMLHRSSMRKMRAADQTSLKYRHQTQSSISSNASSSTTASTSAAAGGGSAQQG 688
            ...:.......|..|....:...:|...|.:.|            |.|||....|...|.....|
Mouse   484 FKGNAPAPVGPLVGLGTVPVTPPQAGPWTPVVY------------SPSTTVVPGAIISGQPPSFG 536

  Fly   689 L-----TSPDSDEGSISSG-------------CETASTVTNA------NHEEYNSKRVSDP---- 725
            .     |:|.....:.|..             |.|.|...||      ....:.|..:..|
Mouse   537 QPLVFGTTPAVQVWNQSPSFATPASPPPPTVWCPTTSVAPNAWSSTSPLGNPFQSNNIFPPPTMS 601

  Fly   726 -----------------------GQLEQSP-----------DLELEQAQVLEQMMIYQRLEQQL- 755
                                   |.|:..|           |.|::  :|.|....:|..:..|
Mouse   602 TQSSPQPMMSSVLATPPQPPPRNGPLKDIPSDAFTGLDPLGDKEVK--EVKEMFKDFQLRQPPLV 664

  Fly   756 --RKNSGDATNYSSSSSITLKRSNSGSDKQERSDHPDDDNSDSDESGYVEFQEKERPGQQPLISE 818
              ||  |:.....:||:.:...:|.....||..||.|.|
Mouse   665 PSRK--GETPPSGTSSAFSSYFNNKVGIPQEHVDHDDFD-------------------------- 701

  Fly   819 ASVTLAKIATVKPQVPPKPAPRRSLSL------NAVATGASAGSSA 858
            |:..|.||     ..|||||||:.:.|      |::....|.|.|:
Mouse   702 ANQLLNKI-----NEPPKPAPRQGVLLGTKSADNSLENPFSKGFSS 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8312	NP_649918.1	PID_2	263..442	CDD:373244	36/182 (20%)
Dab2	NP_075607.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		PTB_Dab	35..171	CDD:269926	22/112 (20%)
		Required for localization to clathrin-coated pits	230..447		45/238 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..482		32/202 (16%)
		PHA03247	<288..608	CDD:223021	56/336 (17%)
		DPF 1	293..295		0/1 (0%)
		DPF 2	298..300		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630		3/33 (9%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000269\|PubMed:9569023	600..730		33/164 (20%)
		Required for interaction with CSK. /evidence=ECO:0000250	617..625		0/7 (0%)
		Required for interaction with MYO6. /evidence=ECO:0000269\|PubMed:11906161	647..766		32/131 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..683		6/25 (24%)
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	661..669		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..766		18/75 (24%)
		Sufficient for interaction with SH3KBP1 SH3 domain	707..723		9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930